Detailed information of TA system TA214583

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 1734460..1734975
• Replicon: chromosome
• Accession: NZ_CP082331
• Organism: Micrococcus luteus strain CW.Ay

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K7G68_RS07830
• Protein ID: WP_049159304.1
• Coordinates: 1734460..1734714 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: D3LMN2
• Locus tag: K7G68_RS07835
• Protein ID: WP_002855277.1
• Coordinates: 1734715..1734975 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K7G68_RS07800 (K7G68_07800)	1729474..1729860	+	387	WP_222958447.1	hypothetical protein	-
K7G68_RS07805 (K7G68_07805)	1729891..1730616	+	726	WP_222958448.1	histidine phosphatase family protein	-
K7G68_RS07810 (K7G68_07810)	1730613..1731155	+	543	WP_222958449.1	DUF3090 domain-containing protein	-
K7G68_RS07815 (K7G68_07815)	1731155..1731937	+	783	WP_222958450.1	SCO1664 family protein	-
K7G68_RS07820 (K7G68_07820)	1731961..1733805	-	1845	WP_222958451.1	Na+/H+ antiporter NhaA	-
K7G68_RS07825 (K7G68_07825)	1733892..1734458	-	567	WP_222958452.1	mismatch-specific DNA-glycosylase	-
K7G68_RS07830 (K7G68_07830)	1734460..1734714	-	255	WP_049159304.1	Txe/YoeB family addiction module toxin	Toxin
K7G68_RS07835 (K7G68_07835)	1734715..1734975	-	261	WP_002855277.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
K7G68_RS07840 (K7G68_07840)	1735301..1736225	+	925	WP_222958453.1	IS5 family transposase	-
K7G68_RS07845 (K7G68_07845)	1736222..1736590	+	369	Protein_1523	FAD-dependent oxidoreductase	-
K7G68_RS07850 (K7G68_07850)	1736818..1737939	+	1122	WP_036334589.1	L-dopachrome tautomerase-related protein	-
K7G68_RS07855 (K7G68_07855)	1738166..1738576	-	411	WP_002855901.1	four-helix bundle copper-binding protein	-
K7G68_RS07860 (K7G68_07860)	1738863..1739868	+	1006	Protein_1526	IS481 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1731961..1742130	10169
	-	flank	IS/Tn	-	-	1738863..1739267	404

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-70)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9984.32 Da
• Isoelectric Point: 7.3151

>T214583 WP_049159304.1 NZ_CP082331:c1734714-1734460 [Micrococcus luteus]
VRLVWDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFEGIGKPEQLKYGAAGAWSRRITEEHRLVYLVDGEDLIILQA
RYHY

Nucleotide

• Length: 255 bp

>T214583 NZ_CP110145:c4190180-4189839 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGACGCTATGTCTGTCGCCCGTGGCAGTCTGGCAAATGCTGCTTGC
ACGCCTGCTAGAACAACATTATGGCCTAACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
GACTGGCAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9579.71 Da
• Isoelectric Point: 4.8359

>AT214583 WP_002855277.1 NZ_CP082331:c1734975-1734715 [Micrococcus luteus]
MSISASEARKTLFPLIERVNADRDAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYERARAGSVEEHALD
RLDGDA

Nucleotide

• Length: 261 bp

>AT214583 NZ_CP110145:c4190518-4190201 [Klebsiella pneumoniae]
ATGAGTAACATCACCTGGGGCCTGCAGCGGAATATCACGCCACGCCTGGGAGCCTGTCTGGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTCAGCGAAGCAGAATGTCTTAAGCTGGATGTGGCATTTCCGC
ATTTTATCAGCCAGATGGAATCGATGCTGACCACTGGTGAAATGAACCCTCGCCATGCACACTGCGTCACCCTGTACCAC
AATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCCGTTTACCCCACTCAACGCTAA

Structures

Antitoxin

• AlphaFold DB: A0A031HW70