Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3405530..3406148 Replicon chromosome
Accession NZ_CP082327
Organism Escherichia coli strain B2

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag K6983_RS16570 Protein ID WP_001291435.1
Coordinates 3405930..3406148 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag K6983_RS16565 Protein ID WP_000344800.1
Coordinates 3405530..3405904 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6983_RS16555 (3400619) 3400619..3401812 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K6983_RS16560 (3401835) 3401835..3404984 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
K6983_RS16565 (3405530) 3405530..3405904 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
K6983_RS16570 (3405930) 3405930..3406148 + 219 WP_001291435.1 HHA domain-containing protein Toxin
K6983_RS16575 (3406320) 3406320..3406871 + 552 WP_000102564.1 maltose O-acetyltransferase -
K6983_RS16580 (3406987) 3406987..3407457 + 471 WP_000136192.1 YlaC family protein -
K6983_RS16585 (3407621) 3407621..3409171 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
K6983_RS16590 (3409213) 3409213..3409566 - 354 WP_000878140.1 DUF1428 domain-containing protein -
K6983_RS16600 (3409945) 3409945..3410256 + 312 WP_000409911.1 MGMT family protein -
K6983_RS16605 (3410287) 3410287..3410859 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T214579 WP_001291435.1 NZ_CP082327:3405930-3406148 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T214579 NZ_CP110145:1511205-1511307 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT214579 WP_000344800.1 NZ_CP082327:3405530-3405904 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT214579 NZ_CP110145:c1511314-1511169 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References