Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 413273..413900 Replicon chromosome
Accession NZ_CP082326
Organism Crassaminicella profunda strain Ra1766H

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag K7H06_RS01750 Protein ID WP_223038271.1
Coordinates 413550..413900 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag K7H06_RS01745 Protein ID WP_223038270.1
Coordinates 413273..413548 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H06_RS01720 (K7H06_01720) 408528..409124 + 597 WP_223038265.1 hypothetical protein -
K7H06_RS01725 (K7H06_01725) 409229..409600 + 372 WP_223038266.1 holo-ACP synthase -
K7H06_RS01730 (K7H06_01730) 409641..411194 + 1554 WP_223038267.1 NAD(P)H-hydrate dehydratase -
K7H06_RS01735 (K7H06_01735) 411265..411888 + 624 WP_223038268.1 outer-membrane lipoprotein carrier protein LolA -
K7H06_RS01740 (K7H06_01740) 411943..413118 + 1176 WP_223038269.1 alanine racemase -
K7H06_RS01745 (K7H06_01745) 413273..413548 + 276 WP_223038270.1 ribbon-helix-helix protein, CopG family Antitoxin
K7H06_RS01750 (K7H06_01750) 413550..413900 + 351 WP_223038271.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
K7H06_RS01755 (K7H06_01755) 414228..417053 + 2826 WP_223038272.1 phosphodiester glycosidase family protein -
K7H06_RS01760 (K7H06_01760) 417193..418305 + 1113 WP_223038273.1 response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12793.76 Da        Isoelectric Point: 6.4704

>T214564 WP_223038271.1 NZ_CP082326:413550-413900 [Crassaminicella profunda]
VIVKRGDIFYADLSPVVGSEQGGVRPVLVVQNNIGNKYSPTVIVAAITSQINKAKLPTHIEISASEYGLTKDSVVLLEQV
RTIDKRRLREKIGHSDDEMMDKVNEALLISFGLIDF

Download         Length: 351 bp

>T214564 NZ_CP110142:4377593-4377970 [Klebsiella pneumoniae]
ATGCAAACCCAACCACTATCCTCAACGCAGGAGGCTACATCACGCCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGTTGGATCGTCACTACGGTCTGACGCTTAACGACACGCCGTTTGGCAACGACGGTGTGATTCAGGAGCATATCG
ACGCCGGTATATCACTGTGCGACGCCGTGAATTTTATTGTGGAGAAGTACGATCTGGTGCGCATCGATCGTCACGGTTTC
AGTACAGAAACACAGTTGCCGCGTCTCACCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGTTGATGACTCGCAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGTGGGGGGCATCGATGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10621.37 Da        Isoelectric Point: 5.2498

>AT214564 WP_223038270.1 NZ_CP082326:413273-413548 [Crassaminicella profunda]
MAESKRIMISLPNTLLQEVDDIVAMDKKNRSEFIREAMKLYIRERRKIQIRESMKKGYREMGAMNLALSEVGLDMDADAL
YNYEAKLAECE

Download         Length: 276 bp

>AT214564 NZ_CP110142:4377183-4377542 [Klebsiella pneumoniae]
TTGTCGAATAAAACACCGATAGTAAACCACGATATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGCGCACGGCTGGTGCAGGCGGGCAACTGTCTGCATTATCTCGCTGACCGGGCCAGCATCACCGGACAGTTCAGCGACG
CGGTTTTACGGCATCTCGACCAGGCATTTCCACTGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCACT
CCCCGCCATCAGCACTGTGTCACGCTCTATGCAAAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGT
ATACCTGGCGATTTATCCGACACCAGCGGCAACCGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References