Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 467757..468409 Replicon chromosome
Accession NZ_CP082323
Organism Thermus thermophilus strain N-1

Toxin (Protein)


Gene name vapC Uniprot ID Q5SKZ2
Locus tag K7H19_RS02605 Protein ID WP_011227982.1
Coordinates 467757..468149 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5SKZ1
Locus tag K7H19_RS02610 Protein ID WP_011227983.1
Coordinates 468149..468409 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H19_RS02580 (K7H19_02580) 464360..464749 + 390 WP_011227977.1 NADH-quinone oxidoreductase subunit 15 -
K7H19_RS02585 (K7H19_02585) 464752..465849 - 1098 WP_011227978.1 radical SAM family heme chaperone HemW -
K7H19_RS02590 (K7H19_02590) 465842..466240 - 399 WP_011227979.1 HEPN domain-containing protein -
K7H19_RS02595 (K7H19_02595) 466230..466547 - 318 WP_011227980.1 nucleotidyltransferase domain-containing protein -
K7H19_RS02600 (K7H19_02600) 466552..467772 - 1221 WP_011227981.1 glycerate kinase -
K7H19_RS02605 (K7H19_02605) 467757..468149 - 393 WP_011227982.1 type II toxin-antitoxin system VapC family toxin Toxin
K7H19_RS02610 (K7H19_02610) 468149..468409 - 261 WP_011227983.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K7H19_RS02615 (K7H19_02615) 468442..469698 - 1257 WP_011227984.1 glycolate oxidase subunit GlcF -
K7H19_RS02620 (K7H19_02620) 469703..470746 - 1044 WP_011227985.1 FAD-binding protein -
K7H19_RS02625 (K7H19_02625) 470733..472115 - 1383 WP_011227986.1 FAD-linked oxidase C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-85)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14636.82 Da        Isoelectric Point: 6.8735

>T214561 WP_011227982.1 NZ_CP082323:c468149-467757 [Thermus thermophilus]
MVLDTSALLGILFREEGYEELLEQLRRTRPHKVAAPTLAEAGIVLGARLGFERVHLLFELLTELQAEIVPFTERHAREAI
SAYRRYGRGKHPAGLNFGDCLSYALARVEGEPLLYKGQGFDRTDLAWKPS

Download         Length: 393 bp

>T214561 NZ_CP110142:2486811-2487128 [Klebsiella pneumoniae]
ATGTTGACTTTTATTGAACTACAAGGTTTCAGTAAGCGACGCCAGGTGCTGTTGCAGGATGATGAATTTCGGGCCTTTCA
GGAAATCCTTATAAACGATCCCGAGGCTGGGGACACAATTTCGGGAACCGGTGGTTTTCGTAAAATTCGCTGGAGTCGTC
CCGGGATGGGGAAGCGCGGCGGTGTACGAGTGATTTACTATAATGTAACGAAAAAGGGAAGAATTTACCTGGCGCTCATC
TATCCTAAAAATGAACAGGATGAGTTAAATCAGGAGCAAAAAAAGATGTTGAGACAAGTGGCTGATTTAATAAACTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10086.61 Da        Isoelectric Point: 5.0285

>AT214561 WP_011227983.1 NZ_CP082323:c468409-468149 [Thermus thermophilus]
MALTIRNKEVERLAEEVARLAGETKTEAVRKALEMRLRELQRKRSFDRVIRFLEEEVWPQIPPELLGKGLSKEEEEEILG
YGKEGY

Download         Length: 261 bp

>AT214561 NZ_CP110142:2487204-2487500 [Klebsiella pneumoniae]
ATGAAAGACGAATTGTTTGCCGATCTGCTGGCGAGTGCAGAAGAAATGGTCAGGATCGAGAAAGGTGAACAAATGCTGAT
GGAGCAGCACGTTCATACCTTCAGCGAAATTGACGTGAAAGCGATACGTGAAGCCACAGGTTTAAAACAGCAGGACTTTG
CAGCGGCCGTTGGCGTTAGCTACGAGTTGGTTAAAAGCTGGGAAACGAAACGACGTCACCCAACCGGTGCAGCCAGAAAG
CTGCTTTTATTGCTTCAGGGTAATCCATTGATTATCAACTTGTTGAAGGTTGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q5SKZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A7R7YHV5

References