Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1972974..1973533 Replicon chromosome
Accession NZ_CP082319
Organism Vibrio alginolyticus strain XWV9

Toxin (Protein)


Gene name relE Uniprot ID A0A2I3C6F2
Locus tag K6806_RS09345 Protein ID WP_005377065.1
Coordinates 1973255..1973533 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2I3C6F3
Locus tag K6806_RS09340 Protein ID WP_005487956.1
Coordinates 1972974..1973258 (+) Length 95 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6806_RS09290 (K6806_09220) 1968097..1968186 - 90 WP_071652537.1 DUF3265 domain-containing protein -
K6806_RS09295 (K6806_09225) 1968216..1968515 - 300 WP_005377019.1 hypothetical protein -
K6806_RS09300 (K6806_09230) 1968545..1968634 - 90 WP_074531724.1 DUF3265 domain-containing protein -
K6806_RS09305 (K6806_09235) 1969166..1969258 - 93 WP_080374080.1 DUF3265 domain-containing protein -
K6806_RS09310 (K6806_09240) 1969284..1969646 - 363 WP_005386966.1 VOC family protein -
K6806_RS09315 1969744..1969828 - 85 Protein_1809 DUF3265 domain-containing protein -
K6806_RS09320 1970247..1970356 - 110 Protein_1810 DUF3265 domain-containing protein -
K6806_RS09325 (K6806_09245) 1970916..1972037 - 1122 WP_053306504.1 hypothetical protein -
K6806_RS09330 (K6806_09250) 1972082..1972174 - 93 WP_077681052.1 DUF3265 domain-containing protein -
K6806_RS09335 (K6806_09255) 1972189..1972773 - 585 WP_238951996.1 hypothetical protein -
K6806_RS09340 (K6806_09260) 1972974..1973258 + 285 WP_005487956.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6806_RS09345 (K6806_09265) 1973255..1973533 + 279 WP_005377065.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
K6806_RS09350 (K6806_09270) 1973562..1973639 - 78 WP_238952359.1 DUF3265 domain-containing protein -
K6806_RS09355 (K6806_09275) 1973785..1973967 + 183 WP_238951997.1 hypothetical protein -
K6806_RS09360 (K6806_09280) 1974048..1974137 - 90 WP_079767000.1 DUF3265 domain-containing protein -
K6806_RS09365 (K6806_09285) 1974155..1974433 - 279 WP_115386111.1 hypothetical protein -
K6806_RS09370 (K6806_09290) 1974524..1974616 - 93 WP_078513198.1 DUF3265 domain-containing protein -
K6806_RS09375 (K6806_09295) 1974631..1975659 - 1029 WP_213909735.1 DUF4238 domain-containing protein -
K6806_RS09380 (K6806_09300) 1975805..1976362 - 558 WP_182039726.1 nucleotidyltransferase family protein -
K6806_RS09385 (K6806_09305) 1976383..1976472 - 90 WP_171345239.1 DUF3265 domain-containing protein -
K6806_RS09390 (K6806_09310) 1976501..1976908 - 408 WP_171345237.1 hypothetical protein -
K6806_RS09395 (K6806_09315) 1977043..1977540 - 498 WP_029848292.1 GNAT family N-acetyltransferase -
K6806_RS09400 (K6806_09320) 1977567..1977659 - 93 WP_072935543.1 DUF3265 domain-containing protein -
K6806_RS09405 (K6806_09325) 1977674..1978174 - 501 WP_238951998.1 hypothetical protein -
K6806_RS09410 (K6806_09330) 1978201..1978329 - 129 WP_080996138.1 DUF3265 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1902984..2016414 113430
- inside Integron - - 1911467..2015296 103829


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10905.60 Da        Isoelectric Point: 4.3430

>T214560 WP_005377065.1 NZ_CP082319:1973255-1973533 [Vibrio alginolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIISYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T214560 NZ_CP110142:1965608-1965710 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11082.40 Da        Isoelectric Point: 9.2167

>AT214560 WP_005487956.1 NZ_CP082319:1972974-1973258 [Vibrio alginolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQNAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT214560 NZ_CP110142:c1965717-1965572 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2I3C6F2


Antitoxin

Source ID Structure
AlphaFold DB A0A2I3C6F3

References