Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1944956..1945484 Replicon chromosome
Accession NZ_CP082319
Organism Vibrio alginolyticus strain XWV9

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag K6806_RS09050 Protein ID WP_005377002.1
Coordinates 1945194..1945484 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag K6806_RS09045 Protein ID WP_005377003.1
Coordinates 1944956..1945204 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6806_RS08995 (K6806_08950) 1940162..1940284 - 123 WP_238951980.1 DUF3265 domain-containing protein -
K6806_RS09000 (K6806_08955) 1940274..1940714 - 441 WP_140361383.1 hypothetical protein -
K6806_RS09005 (K6806_08960) 1940987..1941307 - 321 WP_031382128.1 hypothetical protein -
K6806_RS09010 (K6806_08965) 1941448..1941927 - 480 WP_228076447.1 hypothetical protein -
K6806_RS09015 (K6806_08970) 1942487..1942912 - 426 WP_238951981.1 hypothetical protein -
K6806_RS09020 (K6806_08975) 1942941..1943033 - 93 WP_080254654.1 DUF3265 domain-containing protein -
K6806_RS09025 (K6806_08980) 1943059..1943664 - 606 WP_238951982.1 hypothetical protein -
K6806_RS09030 1943682..1943812 - 131 Protein_1752 DUF3265 domain-containing protein -
K6806_RS09035 (K6806_08985) 1944347..1944760 - 414 WP_182016784.1 hypothetical protein -
K6806_RS09040 (K6806_08990) 1944813..1944881 - 69 WP_074531725.1 DUF3265 domain-containing protein -
K6806_RS09045 (K6806_08995) 1944956..1945204 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6806_RS09050 (K6806_09000) 1945194..1945484 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6806_RS09055 (K6806_09005) 1945631..1946026 - 396 WP_238951983.1 ACT domain-containing protein -
K6806_RS09060 (K6806_09010) 1946162..1946497 - 336 WP_054730774.1 zinc ribbon domain-containing protein YjdM -
K6806_RS09065 1946608..1946721 - 114 WP_238952356.1 DUF3265 domain-containing protein -
K6806_RS09070 (K6806_09015) 1946745..1947470 - 726 WP_238951984.1 hypothetical protein -
K6806_RS09075 (K6806_09020) 1947512..1947604 - 93 WP_199267706.1 DUF3265 domain-containing protein -
K6806_RS09080 (K6806_09025) 1947624..1948256 - 633 WP_238951985.1 hypothetical protein -
K6806_RS09085 (K6806_09030) 1948455..1949597 - 1143 WP_238951986.1 SIR2 family protein -
K6806_RS09090 (K6806_09035) 1949587..1950324 - 738 WP_203346215.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1902984..2016414 113430
- inside Integron - - 1911467..2015296 103829


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T214559 WP_005377002.1 NZ_CP082319:1945194-1945484 [Vibrio alginolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T214559 NZ_CP110142:794520-794930 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT214559 WP_005377003.1 NZ_CP082319:1944956-1945204 [Vibrio alginolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT214559 NZ_CP110142:794273-794539 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References