Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1935673..1936220 Replicon chromosome
Accession NZ_CP082319
Organism Vibrio alginolyticus strain XWV9

Toxin (Protein)


Gene name relE Uniprot ID A0A4P8FYK5
Locus tag K6806_RS08930 Protein ID WP_005377013.1
Coordinates 1935673..1935975 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4P8G149
Locus tag K6806_RS08935 Protein ID WP_005377012.1
Coordinates 1935963..1936220 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6806_RS08890 (K6806_08850) 1931051..1931167 - 117 WP_080936760.1 DUF3265 domain-containing protein -
K6806_RS08895 (K6806_08855) 1931167..1931547 - 381 WP_046875139.1 DUF4087 domain-containing protein -
K6806_RS08900 (K6806_08860) 1931683..1932219 - 537 WP_238951973.1 nucleotidyltransferase family protein -
K6806_RS08905 (K6806_08865) 1932353..1932838 - 486 WP_222717014.1 GNAT family N-acetyltransferase -
K6806_RS08910 1932867..1932956 - 90 WP_080262357.1 DUF3265 domain-containing protein -
K6806_RS08915 (K6806_08875) 1934471..1934563 - 93 WP_238951974.1 DUF3265 domain-containing protein -
K6806_RS08920 (K6806_08880) 1934578..1934943 - 366 WP_238951975.1 T6SS amidase immunity protein Tai4 family protein -
K6806_RS08925 (K6806_08885) 1934925..1935404 - 480 WP_238951976.1 type VI secretion system amidase effector protein Tae4 -
K6806_RS08930 (K6806_08890) 1935673..1935975 - 303 WP_005377013.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6806_RS08935 (K6806_08895) 1935963..1936220 - 258 WP_005377012.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6806_RS08940 (K6806_08900) 1936302..1936394 - 93 WP_193837464.1 DUF3265 domain-containing protein -
K6806_RS08945 (K6806_08905) 1936545..1937030 + 486 WP_238951977.1 hypothetical protein -
K6806_RS08950 (K6806_08910) 1937085..1937174 - 90 WP_081008403.1 DUF3265 domain-containing protein -
K6806_RS08955 (K6806_08915) 1937198..1937797 - 600 WP_238951978.1 hypothetical protein -
K6806_RS08960 (K6806_08920) 1937943..1938311 - 369 WP_065645008.1 hypothetical protein -
K6806_RS08965 (K6806_08925) 1938454..1939086 - 633 WP_176314051.1 hypothetical protein -
K6806_RS08970 (K6806_08930) 1939116..1939208 - 93 WP_071936844.1 DUF3265 domain-containing protein -
K6806_RS08975 (K6806_08935) 1939231..1939494 - 264 WP_045421363.1 hypothetical protein -
K6806_RS08980 (K6806_08940) 1939546..1939608 - 63 WP_079749016.1 DUF3265 domain-containing protein -
K6806_RS08985 1939623..1939829 - 207 WP_238952355.1 GNAT family N-acetyltransferase -
K6806_RS08990 1939872..1940135 - 264 WP_238951979.1 hypothetical protein -
K6806_RS08995 (K6806_08950) 1940162..1940284 - 123 WP_238951980.1 DUF3265 domain-containing protein -
K6806_RS09000 (K6806_08955) 1940274..1940714 - 441 WP_140361383.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1902984..2016414 113430
- inside Integron - - 1911467..2015296 103829


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11651.54 Da        Isoelectric Point: 5.1765

>T214558 WP_005377013.1 NZ_CP082319:c1935975-1935673 [Vibrio alginolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVIRAERDLRKFLLSKQ

Download         Length: 303 bp

>T214558 NZ_CP110142:349413-349760 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9620.12 Da        Isoelectric Point: 6.7269

>AT214558 WP_005377012.1 NZ_CP082319:c1936220-1935963 [Vibrio alginolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVISHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT214558 NZ_CP110142:349760-350059 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P8FYK5

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8G149

References