Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1921062..1921600 Replicon chromosome
Accession NZ_CP082319
Organism Vibrio alginolyticus strain XWV9

Toxin (Protein)


Gene name parE Uniprot ID A0A0F2HTL7
Locus tag K6806_RS08765 Protein ID WP_038940224.1
Coordinates 1921301..1921600 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag K6806_RS08760 Protein ID WP_053304443.1
Coordinates 1921062..1921304 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6806_RS08690 (K6806_08655) 1916366..1916455 - 90 WP_080100183.1 DUF3265 domain-containing protein -
K6806_RS08695 (K6806_08660) 1916620..1916943 - 324 WP_230855327.1 GNAT family N-acetyltransferase -
K6806_RS08700 (K6806_08665) 1916975..1917067 - 93 WP_118121208.1 DUF3265 domain-containing protein -
K6806_RS08705 (K6806_08670) 1917203..1917460 - 258 WP_238951964.1 class I SAM-dependent methyltransferase -
K6806_RS08710 (K6806_08675) 1917505..1917573 - 69 WP_074531725.1 DUF3265 domain-containing protein -
K6806_RS08715 (K6806_08680) 1917648..1917896 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6806_RS08720 (K6806_08685) 1917886..1918176 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6806_RS08725 1918240..1918318 - 79 Protein_1691 DUF3265 domain-containing protein -
K6806_RS08730 (K6806_08690) 1918743..1918835 - 93 WP_079858050.1 DUF3265 domain-containing protein -
K6806_RS08735 (K6806_08695) 1918861..1919103 - 243 WP_080765108.1 zinc ribbon domain-containing protein -
K6806_RS08740 (K6806_08700) 1919236..1919328 - 93 WP_196358505.1 DUF3265 domain-containing protein -
K6806_RS08745 (K6806_08705) 1919747..1920040 - 294 WP_054575586.1 hypothetical protein -
K6806_RS08750 (K6806_08710) 1920139..1920231 - 93 WP_081007977.1 DUF3265 domain-containing protein -
K6806_RS08755 (K6806_08715) 1920246..1920878 - 633 WP_054575587.1 HEPN domain-containing protein -
K6806_RS08760 (K6806_08720) 1921062..1921304 + 243 WP_053304443.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
K6806_RS08765 (K6806_08725) 1921301..1921600 + 300 WP_038940224.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6806_RS08770 (K6806_08730) 1921772..1922164 + 393 WP_054575588.1 hypothetical protein -
K6806_RS08775 (K6806_08735) 1922186..1922278 - 93 WP_080256086.1 DUF3265 domain-containing protein -
K6806_RS08780 (K6806_08740) 1922312..1922728 - 417 WP_017821968.1 lysozyme inhibitor LprI family protein -
K6806_RS08785 (K6806_08745) 1922935..1923159 - 225 WP_031781290.1 hypothetical protein -
K6806_RS08790 (K6806_08750) 1923361..1923573 - 213 WP_029858137.1 hypothetical protein -
K6806_RS08795 (K6806_08755) 1923746..1923877 - 132 WP_081007979.1 DUF3265 domain-containing protein -
K6806_RS08800 (K6806_08760) 1923853..1924245 - 393 WP_238951965.1 SMI1/KNR4 family protein -
K6806_RS08805 (K6806_08765) 1924272..1924364 - 93 WP_080256826.1 DUF3265 domain-containing protein -
K6806_RS08810 (K6806_08770) 1924379..1924777 - 399 WP_238951966.1 hypothetical protein -
K6806_RS08815 (K6806_08775) 1924806..1924895 - 90 WP_230818584.1 DUF3265 domain-containing protein -
K6806_RS08820 (K6806_08780) 1924938..1925252 - 315 WP_238952354.1 hypothetical protein -
K6806_RS08825 (K6806_08785) 1925411..1925764 - 354 WP_213962183.1 hypothetical protein -
K6806_RS08830 (K6806_08790) 1925802..1925894 - 93 WP_017790380.1 DUF3265 domain-containing protein -
K6806_RS08835 (K6806_08795) 1925909..1926340 - 432 WP_238951967.1 DUF1851 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1902984..2016414 113430
- inside Integron - - 1911467..2015296 103829


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11733.42 Da        Isoelectric Point: 9.9572

>T214557 WP_038940224.1 NZ_CP082319:1921301-1921600 [Vibrio alginolyticus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKTCDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T214557 NZ_CP110142:323452-323820 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8939.89 Da        Isoelectric Point: 4.2213

>AT214557 WP_053304443.1 NZ_CP082319:1921062-1921304 [Vibrio alginolyticus]
MAKNTSITLGDHFDGFIANQIQSGRYASASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEEKK

Download         Length: 243 bp

>AT214557 NZ_CP110142:323234-323455 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F2HTL7

Antitoxin

Source ID Structure

References