Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 1357495..1358042 | Replicon | chromosome |
| Accession | NZ_CP082317 | ||
| Organism | Vibrio alginolyticus strain SXV3 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | K6754_RS06635 | Protein ID | WP_238966996.1 |
| Coordinates | 1357740..1358042 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U3A269 |
| Locus tag | K6754_RS06630 | Protein ID | WP_005448240.1 |
| Coordinates | 1357495..1357752 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6754_RS06570 (K6754_06540) | 1352631..1352720 | + | 90 | WP_140382132.1 | DUF3265 domain-containing protein | - |
| K6754_RS06575 (K6754_06545) | 1352749..1353027 | - | 279 | WP_005398411.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| K6754_RS06580 (K6754_06550) | 1353024..1353308 | - | 285 | WP_005398409.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| K6754_RS06585 | 1353385..1353476 | + | 92 | Protein_1216 | DUF3265 domain-containing protein | - |
| K6754_RS06590 (K6754_06560) | 1353621..1353896 | + | 276 | WP_047726024.1 | hypothetical protein | - |
| K6754_RS06595 (K6754_06565) | 1354109..1354918 | + | 810 | WP_053306503.1 | FRG domain-containing protein | - |
| K6754_RS06600 (K6754_06570) | 1354939..1355031 | + | 93 | WP_004748931.1 | DUF3265 domain-containing protein | - |
| K6754_RS06605 (K6754_06575) | 1355076..1356197 | + | 1122 | WP_053306504.1 | hypothetical protein | - |
| K6754_RS06610 (K6754_06580) | 1356351..1356755 | + | 405 | WP_238951994.1 | hydrolase | - |
| K6754_RS06615 (K6754_06585) | 1356787..1356879 | + | 93 | WP_077681052.1 | DUF3265 domain-containing protein | - |
| K6754_RS06620 (K6754_06590) | 1356908..1357306 | + | 399 | WP_238966997.1 | DUF6232 family protein | - |
| K6754_RS06625 (K6754_06595) | 1357321..1357413 | + | 93 | WP_017821407.1 | DUF3265 domain-containing protein | - |
| K6754_RS06630 (K6754_06600) | 1357495..1357752 | + | 258 | WP_005448240.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| K6754_RS06635 (K6754_06605) | 1357740..1358042 | + | 303 | WP_238966996.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K6754_RS06640 (K6754_06610) | 1358223..1358726 | + | 504 | WP_238975175.1 | DUF4236 domain-containing protein | - |
| K6754_RS06645 (K6754_06615) | 1358917..1359225 | + | 309 | WP_004413754.1 | transposase | - |
| K6754_RS06650 (K6754_06620) | 1359275..1360072 | + | 798 | WP_238975177.1 | IS3 family transposase | - |
| K6754_RS06655 (K6754_06625) | 1360126..1360521 | + | 396 | WP_238975179.1 | ACT domain-containing protein | - |
| K6754_RS06660 (K6754_06630) | 1360558..1360647 | + | 90 | WP_238975304.1 | DUF3265 domain-containing protein | - |
| K6754_RS06665 (K6754_06635) | 1360683..1361699 | + | 1017 | WP_234499569.1 | DUF4238 domain-containing protein | - |
| K6754_RS06670 (K6754_06640) | 1361859..1363022 | + | 1164 | WP_238975180.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1316682..1376441 | 59759 | |
| - | inside | Integron | - | - | 1317199..1373707 | 56508 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11624.53 Da Isoelectric Point: 5.8692
>T214554 WP_238966996.1 NZ_CP082317:1357740-1358042 [Vibrio alginolyticus]
MAEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGNKV
FILFVMRAERDLRKFLLGKQ
MAEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGNKV
FILFVMRAERDLRKFLLGKQ
Download Length: 303 bp
>T214554 NZ_CP110141:c1264737-1264480 [Streptococcus suis]
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA
TTGAGTTATAAGGTTATTTTGTCTGCTAAGGCCCAAAAGCAAATTCGAAAGATGGATAAAACCGCTGCAAGTTTGATTTT
GCGCTATCTCTACAAGCATATTGACGGTTGCGACAACCCTAGACAATACGGAAAAGCCTTGACTGCTAATCGTTCTGGCC
AATGGCGCTATCGTATCGGCAATTACAGGGTTATCGTTAATATTGAAGATGATAAATTGATTGTGACAAGCATAAAAATG
AGAAATGGAAGTATATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9606.10 Da Isoelectric Point: 6.7269
>AT214554 WP_005448240.1 NZ_CP082317:1357495-1357752 [Vibrio alginolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
Download Length: 258 bp
>AT214554 NZ_CP110141:c1264966-1264727 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATGACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCCCTTGAAGACGAGTACGATGCGCGTGTGGCAGACGTTGCTTGGGCAG
AATACCAAGCAGACTTGGCGAATAGAATTGAGCCGATGACATTAGAACAAATGGCTGAGGAGTTGGGCATTGAGTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|