Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1400336..1400895 Replicon chromosome
Accession NZ_CP082315
Organism Vibrio alginolyticus strain ZLV3

Toxin (Protein)


Gene name relE Uniprot ID A0A2I3C6F2
Locus tag K6752_RS06925 Protein ID WP_005377065.1
Coordinates 1400336..1400614 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2I3C6F3
Locus tag K6752_RS06930 Protein ID WP_005487956.1
Coordinates 1400611..1400895 (-) Length 95 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6752_RS06860 (K6752_06830) 1396156..1396249 + 94 Protein_1274 DUF3265 domain-containing protein -
K6752_RS06865 (K6752_06835) 1396341..1396619 + 279 WP_017633714.1 hypothetical protein -
K6752_RS06870 (K6752_06840) 1396637..1396726 + 90 WP_081008380.1 DUF3265 domain-containing protein -
K6752_RS06875 (K6752_06845) 1396759..1397160 + 402 WP_005377049.1 HIT family protein -
K6752_RS06880 (K6752_06850) 1397195..1397287 + 93 WP_080276993.1 DUF3265 domain-containing protein -
K6752_RS06885 (K6752_06855) 1397316..1397672 + 357 WP_005377051.1 hypothetical protein -
K6752_RS06890 (K6752_06860) 1398189..1398326 + 138 WP_081008312.1 DUF3265 domain-containing protein -
K6752_RS06895 (K6752_06865) 1398356..1398964 + 609 WP_005377053.1 hypothetical protein -
K6752_RS06900 1398961..1399077 + 117 WP_081008313.1 DUF3265 domain-containing protein -
K6752_RS06905 (K6752_06870) 1399127..1399558 + 432 WP_005377056.1 DUF1851 domain-containing protein -
K6752_RS06910 (K6752_06875) 1399573..1399665 + 93 WP_198136763.1 DUF3265 domain-containing protein -
K6752_RS06915 (K6752_06880) 1399715..1400185 + 471 WP_005377057.1 GNAT family N-acetyltransferase -
K6752_RS06920 (K6752_06885) 1400215..1400307 + 93 WP_004749136.1 DUF3265 domain-containing protein -
K6752_RS06925 (K6752_06890) 1400336..1400614 - 279 WP_005377065.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
K6752_RS06930 (K6752_06895) 1400611..1400895 - 285 WP_005487956.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6752_RS06935 (K6752_06900) 1401096..1401590 + 495 WP_005377068.1 GNAT family N-acetyltransferase -
K6752_RS06940 1401870..1402076 + 207 WP_005377069.1 hypothetical protein -
K6752_RS06945 1402083..1402217 + 135 WP_005377070.1 DUF3265 domain-containing protein -
K6752_RS06950 (K6752_06910) 1402277..1402756 - 480 WP_021033918.1 hypothetical protein -
K6752_RS06955 (K6752_06915) 1403024..1403545 + 522 WP_005377075.1 GNAT family N-acetyltransferase -
K6752_RS06960 (K6752_06920) 1403650..1404051 + 402 WP_005377076.1 DUF2007 domain-containing protein -
K6752_RS06965 (K6752_06925) 1404195..1404803 + 609 WP_005377078.1 pyridoxamine 5'-phosphate oxidase family protein -
K6752_RS06970 (K6752_06930) 1405017..1405358 + 342 WP_005377079.1 RDD family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1337138..1401877 64739


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10905.60 Da        Isoelectric Point: 4.3430

>T214551 WP_005377065.1 NZ_CP082315:c1400614-1400336 [Vibrio alginolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIISYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T214551 NZ_CP110141:461393-461650 [Streptococcus suis]
ATGGGAATCCATTTTACAGAGGATGCCTGGGAAGACTATCTTTATTGGCAAGGTCAGGATAAGAAAACACTCAAGCGAAT
CAATAAGATTATCAAGGATATGCAACGACATCCTTTTGAAGGCATTGCCAAACCAGAACCCTTGAAGTATGATTATCAGG
GTGCCTGGTCTCGGAGAATTGATGCCGAAAATCGGCTGATTTATATGGTAGAAGTAGATAAGCTGTATATTTTGTCTTTA
AAGGATCATTATGGGTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11082.40 Da        Isoelectric Point: 9.2167

>AT214551 WP_005487956.1 NZ_CP082315:c1400895-1400611 [Vibrio alginolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQNAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT214551 NZ_CP110141:461131-461391 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAATCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAACCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTCCTACGTGGTATGGCTAAAGTCAAAACGGGACAAACCAAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2I3C6F2


Antitoxin

Source ID Structure
AlphaFold DB A0A2I3C6F3

References