Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1393255..1393783 Replicon chromosome
Accession NZ_CP082315
Organism Vibrio alginolyticus strain ZLV3

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag K6752_RS06830 Protein ID WP_005377002.1
Coordinates 1393255..1393545 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag K6752_RS06835 Protein ID WP_005377003.1
Coordinates 1393535..1393783 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6752_RS06770 (K6752_06745) 1388644..1389243 + 600 WP_054577357.1 hypothetical protein -
K6752_RS06775 (K6752_06750) 1389267..1389356 + 90 WP_081008403.1 DUF3265 domain-containing protein -
K6752_RS06780 (K6752_06755) 1389390..1389980 + 591 WP_238972251.1 hypothetical protein -
K6752_RS06785 (K6752_06760) 1389995..1390087 + 93 WP_074050578.1 DUF3265 domain-containing protein -
K6752_RS06790 (K6752_06765) 1390512..1390634 + 123 WP_081008400.1 DUF3265 domain-containing protein -
K6752_RS06795 (K6752_06770) 1390663..1390998 + 336 WP_206957870.1 TonB family protein -
K6752_RS06800 (K6752_06775) 1391023..1391112 + 90 WP_080619587.1 DUF3265 domain-containing protein -
K6752_RS06805 (K6752_06780) 1391146..1391520 + 375 WP_140078504.1 hypothetical protein -
K6752_RS06810 (K6752_06785) 1391507..1391626 + 120 WP_071936826.1 DUF3265 domain-containing protein -
K6752_RS06815 (K6752_06790) 1392086..1392175 + 90 WP_213907488.1 DUF3265 domain-containing protein -
K6752_RS06820 (K6752_06795) 1392204..1392716 + 513 WP_005377039.1 hypothetical protein -
K6752_RS06825 (K6752_06800) 1392731..1392823 + 93 WP_198136762.1 DUF3265 domain-containing protein -
K6752_RS06830 (K6752_06805) 1393255..1393545 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6752_RS06835 (K6752_06810) 1393535..1393783 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6752_RS06840 (K6752_06815) 1393858..1393926 + 69 WP_074531725.1 DUF3265 domain-containing protein -
K6752_RS06845 (K6752_06820) 1393974..1394288 + 315 WP_171343458.1 hypothetical protein -
K6752_RS06850 1394291..1394353 + 63 Protein_1272 DUF3265 domain-containing protein -
K6752_RS06855 (K6752_06825) 1395170..1396129 + 960 WP_042524270.1 phosphotransferase -
K6752_RS06860 (K6752_06830) 1396156..1396249 + 94 Protein_1274 DUF3265 domain-containing protein -
K6752_RS06865 (K6752_06835) 1396341..1396619 + 279 WP_017633714.1 hypothetical protein -
K6752_RS06870 (K6752_06840) 1396637..1396726 + 90 WP_081008380.1 DUF3265 domain-containing protein -
K6752_RS06875 (K6752_06845) 1396759..1397160 + 402 WP_005377049.1 HIT family protein -
K6752_RS06880 (K6752_06850) 1397195..1397287 + 93 WP_080276993.1 DUF3265 domain-containing protein -
K6752_RS06885 (K6752_06855) 1397316..1397672 + 357 WP_005377051.1 hypothetical protein -
K6752_RS06890 (K6752_06860) 1398189..1398326 + 138 WP_081008312.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1337138..1401877 64739


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T214550 WP_005377002.1 NZ_CP082315:c1393545-1393255 [Vibrio alginolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T214550 NZ_CP110139:c2876512-2876168 [Hymenobacter sp. YIM 151500-1]
ATGATTTTCTGGCTCGATGCTCAATTGTCGCCGTTATTGGCTGTGTGGCTGCGTTGGAAATTCAAGATTGAGGCATTACC
GCTGCGAGAATTAGGATTACGTGATGCGGAAGATGAAGAAATATTCATAGCAGCAAAAGCTGCTCAGGCTATAGTCATTA
CTAAAGATGCTGACTTTCTGCGGTTACTCGAACGGCTAGGTACGCCACCTCAAATTATATGGCTCACGTGCGGTAACACC
TCAAATGAGCGGTTGCAACAAGTGTTGGTCACCGCTTTGCCAGATGCTATAGAGTTACTGAATGCAGGGGAGCCGTTAGT
AGAAATAGGAGACTTGCTACCGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT214550 WP_005377003.1 NZ_CP082315:c1393783-1393535 [Vibrio alginolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT214550 NZ_CP110139:c2876733-2876509 [Hymenobacter sp. YIM 151500-1]
ATGGAAAACCTACGTCATCGTATTACCGTCAATCCACGCCAATGTGGCGGCCGTCCCTGTATCCGAGGTATGCGCATTCG
GGTGATTGATGTGCTAAACCTGCTGGCAGCAGGGCTCACAGCAGAGCAGGTGCTTGCTGAAATGCCTGATTTAGAACCGC
TTGATATTCAAGCAGCATTACAGTATGCTGCACAGCGTTTAGACTATCCACAATTGGCAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References