Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1348731..1349278 Replicon chromosome
Accession NZ_CP082315
Organism Vibrio alginolyticus strain ZLV3

Toxin (Protein)


Gene name relE Uniprot ID A0A4P8FYK5
Locus tag K6752_RS06385 Protein ID WP_005377013.1
Coordinates 1348976..1349278 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4P8G149
Locus tag K6752_RS06380 Protein ID WP_005377012.1
Coordinates 1348731..1348988 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6752_RS06330 1344092..1344160 + 69 Protein_1169 DUF3265 domain-containing protein -
K6752_RS06335 (K6752_06325) 1344231..1344443 + 213 WP_005376999.1 hypothetical protein -
K6752_RS06340 (K6752_06330) 1344641..1344931 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6752_RS06345 (K6752_06335) 1344921..1345169 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6752_RS06350 (K6752_06340) 1345244..1345312 + 69 WP_074531725.1 DUF3265 domain-containing protein -
K6752_RS06355 (K6752_06345) 1345431..1346261 + 831 WP_005377004.1 abortive infection family protein -
K6752_RS06360 (K6752_06350) 1346279..1346368 + 90 WP_082245230.1 DUF3265 domain-containing protein -
K6752_RS06365 (K6752_06355) 1346414..1347304 + 891 WP_005377010.1 hypothetical protein -
K6752_RS06370 (K6752_06360) 1347419..1348129 + 711 WP_025502549.1 DUF4145 domain-containing protein -
K6752_RS06375 (K6752_06365) 1348144..1348236 + 93 Protein_1178 DUF3265 domain-containing protein -
K6752_RS06380 (K6752_06370) 1348731..1348988 + 258 WP_005377012.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6752_RS06385 (K6752_06375) 1348976..1349278 + 303 WP_005377013.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6752_RS06390 (K6752_06380) 1349314..1349406 + 93 WP_005377014.1 DUF3265 domain-containing protein -
K6752_RS06395 (K6752_06385) 1349433..1349840 + 408 WP_005377015.1 hypothetical protein -
K6752_RS06400 (K6752_06390) 1349809..1349958 + 150 WP_082245218.1 DUF3265 domain-containing protein -
K6752_RS06405 1350157..1350477 + 321 WP_230623508.1 tetratricopeptide repeat protein -
K6752_RS06410 (K6752_06400) 1350515..1350583 + 69 WP_230623510.1 DUF3265 domain-containing protein -
K6752_RS06415 (K6752_06405) 1350610..1351170 + 561 WP_005377017.1 hypothetical protein -
K6752_RS06420 (K6752_06410) 1351696..1351824 + 129 WP_072615951.1 DUF3265 domain-containing protein -
K6752_RS06425 (K6752_06415) 1352282..1352371 + 90 WP_079858647.1 DUF3265 domain-containing protein -
K6752_RS06430 (K6752_06420) 1352462..1352740 + 279 WP_005377018.1 hypothetical protein -
K6752_RS06435 (K6752_06425) 1352758..1352847 + 90 WP_077345960.1 DUF3265 domain-containing protein -
K6752_RS06440 (K6752_06430) 1353290..1353589 + 300 WP_213907484.1 hypothetical protein -
K6752_RS06445 (K6752_06435) 1353619..1353708 + 90 WP_071652537.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1337138..1401877 64739


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11651.54 Da        Isoelectric Point: 5.1765

>T214549 WP_005377013.1 NZ_CP082315:1348976-1349278 [Vibrio alginolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVIRAERDLRKFLLSKQ

Download         Length: 303 bp

>T214549 NZ_CP110136:c2658283-2657966 [Hymenobacter sp. YIM 151858-1]
ATGACGCTTTGGTTGGATGCGCAGCTTTCGCCGTTACTGGCTGTTTGGTTGCGGTGGAAGTTCGGATTAAACGCCTCGGC
ATTGCGCGATATAGGCCTGCGCGACGCCAAAGACGAGGAAATATTCCGGGCGGCCCGAACTGCCAATGCAGTGGTGGTAT
CCAAAGACGCTGACTTCCTGCGTTTGCTGGAACGGTATGGGCCACCGCCGCAAATTATCTGGATTACGTGCGGCAACACG
GCTAACGAGCGGCTGCAACAGGTACTGCTAGCCACATTGCCAGCGGCGTTGGAATTGCTGGCGGCGAGCCGTTGGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9620.12 Da        Isoelectric Point: 6.7269

>AT214549 WP_005377012.1 NZ_CP082315:1348731-1348988 [Vibrio alginolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVISHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT214549 NZ_CP110136:c2658504-2658280 [Hymenobacter sp. YIM 151858-1]
ATGGATTCCCTTCGTCAGCGCATTACCTCCGACCCGCAGCAATGCGGTGGTCGGCCTTGCATCCGTGGCATGCGCATCCG
CGTAGCCGACGTGCTGAATCTTTTAGCGGCTGGCTTGAGTGCTGAGCAGGTGCTGGCAGAAATGCCCGACCTGGAGCCAC
TCGATATTCAGGCGGCGCTGCAATACGCTGCGCAGCGGCTCGATCATCCCTCGCTGGCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P8FYK5

Antitoxin

Source ID Structure
AlphaFold DB A0A4P8G149

References