Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1344641..1345169 Replicon chromosome
Accession NZ_CP082315
Organism Vibrio alginolyticus strain ZLV3

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag K6752_RS06340 Protein ID WP_005377002.1
Coordinates 1344641..1344931 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag K6752_RS06345 Protein ID WP_005377003.1
Coordinates 1344921..1345169 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6752_RS06295 (K6752_06290) 1340605..1340697 + 93 WP_079748816.1 DUF3265 domain-containing protein -
K6752_RS06300 (K6752_06295) 1340736..1341263 + 528 WP_225492310.1 DUF2846 domain-containing protein -
K6752_RS06305 (K6752_06300) 1341281..1341394 + 114 Protein_1164 DUF3265 domain-containing protein -
K6752_RS06310 (K6752_06305) 1341581..1341754 + 174 WP_238972245.1 hypothetical protein -
K6752_RS06315 (K6752_06310) 1341735..1342022 + 288 WP_238972246.1 hypothetical protein -
K6752_RS06320 (K6752_06315) 1343137..1343457 + 321 WP_005376995.1 DUF2834 domain-containing protein -
K6752_RS06325 (K6752_06320) 1343589..1344098 + 510 WP_005376997.1 hypothetical protein -
K6752_RS06330 1344092..1344160 + 69 Protein_1169 DUF3265 domain-containing protein -
K6752_RS06335 (K6752_06325) 1344231..1344443 + 213 WP_005376999.1 hypothetical protein -
K6752_RS06340 (K6752_06330) 1344641..1344931 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6752_RS06345 (K6752_06335) 1344921..1345169 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6752_RS06350 (K6752_06340) 1345244..1345312 + 69 WP_074531725.1 DUF3265 domain-containing protein -
K6752_RS06355 (K6752_06345) 1345431..1346261 + 831 WP_005377004.1 abortive infection family protein -
K6752_RS06360 (K6752_06350) 1346279..1346368 + 90 WP_082245230.1 DUF3265 domain-containing protein -
K6752_RS06365 (K6752_06355) 1346414..1347304 + 891 WP_005377010.1 hypothetical protein -
K6752_RS06370 (K6752_06360) 1347419..1348129 + 711 WP_025502549.1 DUF4145 domain-containing protein -
K6752_RS06375 (K6752_06365) 1348144..1348236 + 93 Protein_1178 DUF3265 domain-containing protein -
K6752_RS06380 (K6752_06370) 1348731..1348988 + 258 WP_005377012.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
K6752_RS06385 (K6752_06375) 1348976..1349278 + 303 WP_005377013.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6752_RS06390 (K6752_06380) 1349314..1349406 + 93 WP_005377014.1 DUF3265 domain-containing protein -
K6752_RS06395 (K6752_06385) 1349433..1349840 + 408 WP_005377015.1 hypothetical protein -
K6752_RS06400 (K6752_06390) 1349809..1349958 + 150 WP_082245218.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1337138..1401877 64739


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T214548 WP_005377002.1 NZ_CP082315:c1344931-1344641 [Vibrio alginolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T214548 NZ_CP110131:c5418765-5418475 [Methylorubrum extorquens]
ATGAGCGTCCGCCTCTCGCCGAGGGCGCGCGGGGATCTCAGCCGGATCTGGGACGATTCGGCCGAGCGCTGGGGAGCGGA
TCAGGCCGACCGCTACATCCGCCTTCTGGCTGGAGGCTTCGACCGATTGGCGGAGGATCCGGCTCGGGGTCTAAGGGCCG
ATGAGATCCGCAAGGGGTATTTCCGCCTCTCCGTCGGATCGCACGTCCTATTCTACCGCCTGGGCGCCGAGGGCGGCATC
GAGGTCATCCGCATCCTTCACGGGCGGATGGATTTCAAACGCCATCTTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT214548 WP_005377003.1 NZ_CP082315:c1345169-1344921 [Vibrio alginolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT214548 NZ_CP110131:c5419010-5418762 [Methylorubrum extorquens]
ATGTCGCGAAACACGTCCGTCTCGCTCGGCGAGCACTTTGCGCAGTTCATCGACCGCCAGGTCGAGGGGGGACGTTACGG
CTCCGCCAGCGAAGTCGTCCGTGCCGGACTTCGTCTTCTGGAGGAGCAGGAAGCCGCCCTCAACACGCTCCGGGCCGCGC
TGATCGAGGGGGAGGAAAGCGGCTCGCCCGAGCCCTTCGATACGGAGACCTTTCTCCGGGAGAAGCGTGAGGGCGCGATC
CGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References