Detailed information of TA system TA214547

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 1368788..1369353
• Replicon: chromosome
• Accession: NZ_CP082313
• Organism: Vibrio alginolyticus strain ZZV2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K6750_RS06685
• Protein ID: WP_238967021.1
• Coordinates: 1369066..1369353 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3BLE1
• Locus tag: K6750_RS06680
• Protein ID: WP_000086647.1
• Coordinates: 1368788..1369069 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6750_RS06620 (K6750_06600)	1363968..1364807	+	840	WP_238967018.1	DUF2569 domain-containing protein	-
K6750_RS06625 (K6750_06605)	1364832..1364924	+	93	WP_079753404.1	DUF3265 domain-containing protein	-
K6750_RS06630 (K6750_06610)	1365352..1365441	+	90	WP_238967073.1	DUF3265 domain-containing protein	-
K6750_RS06635 (K6750_06615)	1365479..1365832	+	354	WP_238967019.1	hypothetical protein	-
K6750_RS06640 (K6750_06620)	1365931..1366281	+	351	Protein_1228	hypothetical protein	-
K6750_RS06645 (K6750_06625)	1366431..1367051	+	621	WP_171345235.1	hypothetical protein	-
K6750_RS06650	1367187..1367639	+	453	WP_238967020.1	hypothetical protein	-
K6750_RS06655 (K6750_06630)	1367666..1367758	+	93	WP_238967074.1	DUF3265 domain-containing protein	-
K6750_RS06660 (K6750_06635)	1367798..1368145	+	348	WP_031780756.1	hypothetical protein	-
K6750_RS06665 (K6750_06640)	1368160..1368251	+	92	Protein_1233	DUF3265 domain-containing protein	-
K6750_RS06670 (K6750_06645)	1368285..1368578	+	294	WP_230689976.1	hypothetical protein	-
K6750_RS06675 (K6750_06650)	1368608..1368697	+	90	WP_230624577.1	DUF3265 domain-containing protein	-
K6750_RS06680 (K6750_06655)	1368788..1369069	+	282	WP_000086647.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K6750_RS06685 (K6750_06660)	1369066..1369353	+	288	WP_238967021.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K6750_RS06690 (K6750_06665)	1369363..1369473	+	111	WP_238967075.1	DUF3265 domain-containing protein	-
K6750_RS06695 (K6750_06670)	1369531..1369746	+	216	WP_025611452.1	hypothetical protein	-
K6750_RS06700 (K6750_06675)	1369749..1370120	+	372	WP_238967022.1	hypothetical protein	-
K6750_RS06705 (K6750_06680)	1371026..1371304	+	279	WP_033905615.1	hypothetical protein	-
K6750_RS06710 (K6750_06685)	1371322..1371411	+	90	WP_072833118.1	DUF3265 domain-containing protein	-
K6750_RS06715 (K6750_06690)	1371456..1371740	+	285	WP_029833179.1	MazG nucleotide pyrophosphohydrolase domain-containing protein	-
K6750_RS06720	1371718..1371804	+	87	Protein_1244	DUF3265 domain-containing protein	-
K6750_RS06730 (K6750_06700)	1371896..1372243	+	348	WP_054577336.1	hypothetical protein	-
K6750_RS06735 (K6750_06705)	1372503..1372679	+	177	WP_154218409.1	hypothetical protein	-
K6750_RS06740 (K6750_06710)	1372683..1373087	+	405	WP_151514870.1	type II toxin-antitoxin system YafO family toxin	-
K6750_RS06745 (K6750_06715)	1373096..1373368	+	273	WP_005445731.1	hypothetical protein	-
K6750_RS06750 (K6750_06720)	1374010..1374099	+	90	WP_077672880.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	vxsC / exsA / exsD / vscB / vscC / vscD / vscF / vscG / vscH / vscI / vscJ / vscK / vscL / vopS / vopR / vecA / vopQ / vscU / vscT / vscS / vscR / vscQ / vscO / vscN / vopN / tyeA/vcr1 / sycN/vcr2 / vscX / vscY / vcrD / vcrR / vcrG / vcrV / vcrH / vopB / vopD / VP1611	1310270..1793048	482778
	-	inside	Integron	-	-	1356957..1393155	36198

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11022.67 Da
• Isoelectric Point: 4.8177

>T214547 WP_238967021.1 NZ_CP082313:1369066-1369353 [Vibrio alginolyticus]
MKVVWSPLALQKLGDTAEFISLDNPLAAERWVNEVFDKTELLGSMPEVGRFVPEMPHTNYREIIFGNYRIIYSLSHEIRV
LTVRNCRQILSEDDV

Nucleotide

• Length: 288 bp

>T214547 NZ_CP110131:c5303064-5302783 [Methylorubrum extorquens]
ATGATCCTCAGCTACCGCAACAGGGGCACCGAAGCGCTGGACGTGCACGGTGTGTGCCATCGCCGCTGGCGGTCCTTTCA
AGCTGCGGCCGGGCGCAAGCTCGATATGCTGAACGCCGCCTCCGTCGTGAGCGACCTGCGCAGCCCGCCCGGCAACCGTC
TGGAGAAGCTGTCGGGTGATCGCGAGGGCCAGTGGAGCATCCGCATCAACGATCAATGGCGCATCTGCTTCCGATGGGAC
GGTTCGGGGCCCGAGGATGTCGAGATTGTCGATTATCACTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10398.91 Da
• Isoelectric Point: 5.8650

>AT214547 WP_000086647.1 NZ_CP082313:1368788-1369069 [Vibrio alginolyticus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT214547 NZ_CP110131:c5302769-5302485 [Methylorubrum extorquens]
ATGCCTCGCATTAGATCTCATCCGGGCGAGATCCTGCTCGAAGAATACCTTCGACCCCTGGAAATGAGCGCCAACGCTCT
GGCGAAGGCGATCGAGGTGCCAGCCAACCGCATCAGCGAACTTCTGCGCGGTCGCCGCGGGATGACCGCCGACACGGCCT
GCCGCCTCGGCCGGTTCTTCGGGACCACGCCGGAATTCTGGATGAGTCTCCAGACCGCCCACGATCTGTCGAGGGCCGTC
GCGGAGCACGACTATTCCACCTTGCGTGCTCTCGAAAGCGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A4P8G0X0