Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 1323661..1324199 | Replicon | chromosome |
| Accession | NZ_CP082313 | ||
| Organism | Vibrio alginolyticus strain ZZV2 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | K6750_RS06270 | Protein ID | WP_238966991.1 |
| Coordinates | 1323661..1323960 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | K6750_RS06275 | Protein ID | WP_053304443.1 |
| Coordinates | 1323957..1324199 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6750_RS06230 (K6750_06235) | 1319701..1319967 | + | 267 | WP_238966989.1 | hypothetical protein | - |
| K6750_RS06235 (K6750_06240) | 1320173..1321363 | - | 1191 | WP_238966990.1 | hypothetical protein | - |
| K6750_RS06240 (K6750_06245) | 1322027..1322155 | + | 129 | WP_099098883.1 | DUF3265 domain-containing protein | - |
| K6750_RS06245 (K6750_06250) | 1322183..1322779 | + | 597 | WP_137282136.1 | DJ-1/PfpI family protein | - |
| K6750_RS06250 (K6750_06255) | 1322766..1322897 | + | 132 | WP_137282126.1 | DUF3265 domain-containing protein | - |
| K6750_RS06255 (K6750_06260) | 1322926..1323204 | - | 279 | WP_005398411.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| K6750_RS06260 (K6750_06265) | 1323201..1323485 | - | 285 | WP_005398409.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| K6750_RS06265 (K6750_06270) | 1323562..1323653 | + | 92 | Protein_1155 | DUF3265 domain-containing protein | - |
| K6750_RS06270 (K6750_06275) | 1323661..1323960 | - | 300 | WP_238966991.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K6750_RS06275 (K6750_06280) | 1323957..1324199 | - | 243 | WP_053304443.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| K6750_RS06280 (K6750_06285) | 1324422..1325480 | + | 1059 | WP_222784187.1 | hypothetical protein | - |
| K6750_RS06285 (K6750_06290) | 1325503..1325595 | + | 93 | WP_079855847.1 | DUF3265 domain-containing protein | - |
| K6750_RS06290 (K6750_06295) | 1325628..1326029 | + | 402 | WP_023585550.1 | HIT family protein | - |
| K6750_RS06295 (K6750_06300) | 1326064..1326156 | + | 93 | WP_079878770.1 | DUF3265 domain-containing protein | - |
| K6750_RS06300 (K6750_06305) | 1326709..1327578 | - | 870 | WP_167426473.1 | P63C domain-containing protein | - |
| K6750_RS06305 | 1327688..1327750 | + | 63 | Protein_1163 | DUF3265 domain-containing protein | - |
| K6750_RS06310 (K6750_06310) | 1327834..1328523 | + | 690 | WP_238966992.1 | hypothetical protein | - |
| K6750_RS06315 (K6750_06315) | 1328629..1329171 | + | 543 | WP_017821418.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | vxsC / exsA / exsD / vscB / vscC / vscD / vscF / vscG / vscH / vscI / vscJ / vscK / vscL / vopS / vopR / vecA / vopQ / vscU / vscT / vscS / vscR / vscQ / vscO / vscN / vopN / tyeA/vcr1 / sycN/vcr2 / vscX / vscY / vcrD / vcrR / vcrG / vcrV / vcrH / vopB / vopD / VP1611 | 1310270..1793048 | 482778 | |
| - | inside | Integron | - | - | 1320173..1343623 | 23450 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11703.39 Da Isoelectric Point: 9.9572
>T214545 WP_238966991.1 NZ_CP082313:c1323960-1323661 [Vibrio alginolyticus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAESPDIGKACDEIRDGYRKFPQGSHVIFYRQIGNQN
IEIIRILHKSMDVNPIFGA
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAESPDIGKACDEIRDGYRKFPQGSHVIFYRQIGNQN
IEIIRILHKSMDVNPIFGA
Download Length: 300 bp
>T214545 NZ_CP110131:3739861-3740154 [Methylorubrum extorquens]
ATGATGACGGAAACCAGCCCCTACGACTCGGCCGAATTCCTGGAAAGCGATGAGGCGGTTGCCGAGTATCTGGCTGCGGC
CATCGAAGAAGGAGACGCTGCGCTGTTTCGCCGGGCGCTCGGTGTCGCGGCCCGCGCGCGTGGCATGACCCAGATCGCTC
GGGAGACAGGTTTATCGCGGGAAAGCCTCTATCGGGCGTTGTCGGACGACGGCAACCCGAGCCTCGACACGGCTCTGCGC
GTCCTGAATGCCTTGAACGTCCGCCTGACGGCATCGGTCGCCTCTCCTCAGTGA
ATGATGACGGAAACCAGCCCCTACGACTCGGCCGAATTCCTGGAAAGCGATGAGGCGGTTGCCGAGTATCTGGCTGCGGC
CATCGAAGAAGGAGACGCTGCGCTGTTTCGCCGGGCGCTCGGTGTCGCGGCCCGCGCGCGTGGCATGACCCAGATCGCTC
GGGAGACAGGTTTATCGCGGGAAAGCCTCTATCGGGCGTTGTCGGACGACGGCAACCCGAGCCTCGACACGGCTCTGCGC
GTCCTGAATGCCTTGAACGTCCGCCTGACGGCATCGGTCGCCTCTCCTCAGTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8939.89 Da Isoelectric Point: 4.2213
>AT214545 WP_053304443.1 NZ_CP082313:c1324199-1323957 [Vibrio alginolyticus]
MAKNTSITLGDHFDGFIANQIQSGRYASASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEEKK
MAKNTSITLGDHFDGFIANQIQSGRYASASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEEKK
Download Length: 243 bp
>AT214545 NZ_CP110131:3739562-3739864 [Methylorubrum extorquens]
ATGCTGGAGATCATCCGCACCCGAACGTTCGCGGATTGGCTCAAGGGGCTTCGGGACGATCGCGCAAAGGCACGGATCGC
GTTGCGGATCGATCGCCTCGCACTCGGCCATGAGGGTGATTCGAAAGCTGTCGGCGGTGGCGTCAGCGAGTTGCGGATCG
ACTACGGACCGGGCTACCGGATCTACTTCACGTATCGTGGCAAGACCCTGGTCGTCCTGCTGTGCGGCGGGGACAAGGCG
AGCCAGAAGCGCGACATTTCCCGAGCGAAGACCTTGGCGACGATGCTGGACGGAACGGAATGA
ATGCTGGAGATCATCCGCACCCGAACGTTCGCGGATTGGCTCAAGGGGCTTCGGGACGATCGCGCAAAGGCACGGATCGC
GTTGCGGATCGATCGCCTCGCACTCGGCCATGAGGGTGATTCGAAAGCTGTCGGCGGTGGCGTCAGCGAGTTGCGGATCG
ACTACGGACCGGGCTACCGGATCTACTTCACGTATCGTGGCAAGACCCTGGTCGTCCTGCTGTGCGGCGGGGACAAGGCG
AGCCAGAAGCGCGACATTTCCCGAGCGAAGACCTTGGCGACGATGCTGGACGGAACGGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|