Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1322926..1323485 Replicon chromosome
Accession NZ_CP082313
Organism Vibrio alginolyticus strain ZZV2

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag K6750_RS06255 Protein ID WP_005398411.1
Coordinates 1322926..1323204 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag K6750_RS06260 Protein ID WP_005398409.1
Coordinates 1323201..1323485 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6750_RS06220 (K6750_06225) 1318020..1318271 + 252 WP_238966987.1 endonuclease domain-containing protein -
K6750_RS06225 (K6750_06230) 1318264..1319235 + 972 WP_238966988.1 DUF968 domain-containing protein -
K6750_RS06230 (K6750_06235) 1319701..1319967 + 267 WP_238966989.1 hypothetical protein -
K6750_RS06235 (K6750_06240) 1320173..1321363 - 1191 WP_238966990.1 hypothetical protein -
K6750_RS06240 (K6750_06245) 1322027..1322155 + 129 WP_099098883.1 DUF3265 domain-containing protein -
K6750_RS06245 (K6750_06250) 1322183..1322779 + 597 WP_137282136.1 DJ-1/PfpI family protein -
K6750_RS06250 (K6750_06255) 1322766..1322897 + 132 WP_137282126.1 DUF3265 domain-containing protein -
K6750_RS06255 (K6750_06260) 1322926..1323204 - 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
K6750_RS06260 (K6750_06265) 1323201..1323485 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6750_RS06265 (K6750_06270) 1323562..1323653 + 92 Protein_1155 DUF3265 domain-containing protein -
K6750_RS06270 (K6750_06275) 1323661..1323960 - 300 WP_238966991.1 type II toxin-antitoxin system RelE/ParE family toxin -
K6750_RS06275 (K6750_06280) 1323957..1324199 - 243 WP_053304443.1 type II toxin-antitoxin system ParD family antitoxin -
K6750_RS06280 (K6750_06285) 1324422..1325480 + 1059 WP_222784187.1 hypothetical protein -
K6750_RS06285 (K6750_06290) 1325503..1325595 + 93 WP_079855847.1 DUF3265 domain-containing protein -
K6750_RS06290 (K6750_06295) 1325628..1326029 + 402 WP_023585550.1 HIT family protein -
K6750_RS06295 (K6750_06300) 1326064..1326156 + 93 WP_079878770.1 DUF3265 domain-containing protein -
K6750_RS06300 (K6750_06305) 1326709..1327578 - 870 WP_167426473.1 P63C domain-containing protein -
K6750_RS06305 1327688..1327750 + 63 Protein_1163 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vxsC / exsA / exsD / vscB / vscC / vscD / vscF / vscG / vscH / vscI / vscJ / vscK / vscL / vopS / vopR / vecA / vopQ / vscU / vscT / vscS / vscR / vscQ / vscO / vscN / vopN / tyeA/vcr1 / sycN/vcr2 / vscX / vscY / vcrD / vcrR / vcrG / vcrV / vcrH / vopB / vopD / VP1611 1310270..1793048 482778
- inside Integron - - 1320173..1343623 23450


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T214544 WP_005398411.1 NZ_CP082313:c1323204-1322926 [Vibrio alginolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T214544 NZ_CP110131:3739562-3739864 [Methylorubrum extorquens]
ATGCTGGAGATCATCCGCACCCGAACGTTCGCGGATTGGCTCAAGGGGCTTCGGGACGATCGCGCAAAGGCACGGATCGC
GTTGCGGATCGATCGCCTCGCACTCGGCCATGAGGGTGATTCGAAAGCTGTCGGCGGTGGCGTCAGCGAGTTGCGGATCG
ACTACGGACCGGGCTACCGGATCTACTTCACGTATCGTGGCAAGACCCTGGTCGTCCTGCTGTGCGGCGGGGACAAGGCG
AGCCAGAAGCGCGACATTTCCCGAGCGAAGACCTTGGCGACGATGCTGGACGGAACGGAATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT214544 WP_005398409.1 NZ_CP082313:c1323485-1323201 [Vibrio alginolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT214544 NZ_CP110131:3739861-3740154 [Methylorubrum extorquens]
ATGATGACGGAAACCAGCCCCTACGACTCGGCCGAATTCCTGGAAAGCGATGAGGCGGTTGCCGAGTATCTGGCTGCGGC
CATCGAAGAAGGAGACGCTGCGCTGTTTCGCCGGGCGCTCGGTGTCGCGGCCCGCGCGCGTGGCATGACCCAGATCGCTC
GGGAGACAGGTTTATCGCGGGAAAGCCTCTATCGGGCGTTGTCGGACGACGGCAACCCGAGCCTCGACACGGCTCTGCGC
GTCCTGAATGCCTTGAACGTCCGCCTGACGGCATCGGTCGCCTCTCCTCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR22

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References