Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 2009426..2009973 | Replicon | chromosome |
| Accession | NZ_CP082310 | ||
| Organism | Vibrio alginolyticus strain HYV1 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A7Z2MSV0 |
| Locus tag | K6749_RS09450 | Protein ID | WP_025527253.1 |
| Coordinates | 2009426..2009728 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U3A269 |
| Locus tag | K6749_RS09455 | Protein ID | WP_005448240.1 |
| Coordinates | 2009716..2009973 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6749_RS09400 (K6749_09325) | 2005032..2005571 | - | 540 | WP_238969960.1 | hypothetical protein | - |
| K6749_RS09405 (K6749_09330) | 2005606..2005734 | - | 129 | WP_099098883.1 | DUF3265 domain-containing protein | - |
| K6749_RS09410 (K6749_09335) | 2006153..2006245 | - | 93 | WP_192947860.1 | DUF3265 domain-containing protein | - |
| K6749_RS09415 (K6749_09340) | 2006403..2006831 | - | 429 | Protein_1826 | class I SAM-dependent methyltransferase | - |
| K6749_RS09420 (K6749_09345) | 2006942..2007031 | - | 90 | WP_138938239.1 | DUF3265 domain-containing protein | - |
| K6749_RS09425 (K6749_09350) | 2007552..2007641 | - | 90 | WP_109170471.1 | DUF3265 domain-containing protein | - |
| K6749_RS09430 (K6749_09355) | 2007668..2008048 | - | 381 | WP_045407178.1 | DUF4087 domain-containing protein | - |
| K6749_RS09435 (K6749_09360) | 2008076..2008192 | - | 117 | WP_080931826.1 | DUF3265 domain-containing protein | - |
| K6749_RS09440 (K6749_09365) | 2008199..2008720 | - | 522 | WP_140192212.1 | GNAT family N-acetyltransferase | - |
| K6749_RS09445 | 2008748..2008876 | - | 129 | WP_238970379.1 | DUF3265 domain-containing protein | - |
| K6749_RS09450 (K6749_09370) | 2009426..2009728 | - | 303 | WP_025527253.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K6749_RS09455 (K6749_09375) | 2009716..2009973 | - | 258 | WP_005448240.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| K6749_RS09460 (K6749_09380) | 2010182..2010616 | - | 435 | WP_029836265.1 | DUF1851 domain-containing protein | - |
| K6749_RS09465 (K6749_09385) | 2010754..2011485 | - | 732 | WP_069523617.1 | HNH endonuclease | - |
| K6749_RS09470 (K6749_09390) | 2011729..2012691 | + | 963 | WP_238969961.1 | integron integrase | - |
| K6749_RS09475 (K6749_09395) | 2012735..2013208 | - | 474 | WP_017636094.1 | DUF2947 domain-containing protein | - |
| K6749_RS09480 (K6749_09400) | 2013222..2013809 | - | 588 | WP_005376917.1 | HD domain-containing protein | - |
| K6749_RS09485 (K6749_09405) | 2013811..2014395 | - | 585 | WP_005388271.1 | ribosomal protein S5-alanine N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1966339..2013809 | 47470 | |
| - | inside | Integron | - | - | 1967523..2012691 | 45168 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11640.53 Da Isoelectric Point: 4.8951
>T214542 WP_025527253.1 NZ_CP082310:c2009728-2009426 [Vibrio alginolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLEAFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLEAFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
Download Length: 303 bp
>T214542 NZ_CP110131:1150712-1150987 [Methylorubrum extorquens]
ATGTTGATTGTCTGGGACGAGCCCAAGCGCCTGACCAACCTGCAAAAGCACGGTCTCGACTTCGCGGACTTCGAGGCGGG
GTTCGACTTCGAGACCTCTCTTGTCGCGGTTGCCCAACCGAGCGCCGCTGGCTCAGCCCGAATGAAGATCATCGGCGAGT
TCGACGGACAGACGGTGGTGGCAGCGATCATCGCTCCCTTGGGACGGGAAGCGATCTCGCTCATCAGCCTGCGCCGAGCC
AGCCGGAGCGAACGGAGGCTCTACGATGCCCGCTGA
ATGTTGATTGTCTGGGACGAGCCCAAGCGCCTGACCAACCTGCAAAAGCACGGTCTCGACTTCGCGGACTTCGAGGCGGG
GTTCGACTTCGAGACCTCTCTTGTCGCGGTTGCCCAACCGAGCGCCGCTGGCTCAGCCCGAATGAAGATCATCGGCGAGT
TCGACGGACAGACGGTGGTGGCAGCGATCATCGCTCCCTTGGGACGGGAAGCGATCTCGCTCATCAGCCTGCGCCGAGCC
AGCCGGAGCGAACGGAGGCTCTACGATGCCCGCTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9606.10 Da Isoelectric Point: 6.7269
>AT214542 WP_005448240.1 NZ_CP082310:c2009973-2009716 [Vibrio alginolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
Download Length: 258 bp
>AT214542 NZ_CP110131:1150977-1151294 [Methylorubrum extorquens]
ATGCCCGCTGACAAGCCCGATCGGAGACCGACCACGACCTCGGAGGAGGCCGGGATCCAAGCCGGCATCGCGGCCGATCC
CGACAATCCGGAATGGACCGAAGCGGACTTTCGAAGCGCCGTGCCCTTCGAACAGGCCTTTCCCGTCCTCGCAGAGAAAC
TGCGCCGCACCCGCGGCCCCCAAAGCGCTCCGACCAAACAGCTCGTCAGCTTGAGGCTCGATCAGGACGTCCTGCTTCGT
TTCAGGGCGACCGGTCCGGGCTGGCAGTCTCGGATGAACGAAGCCCTGCGCCGGGCCGCGGCCGATCTTCCCGACTGA
ATGCCCGCTGACAAGCCCGATCGGAGACCGACCACGACCTCGGAGGAGGCCGGGATCCAAGCCGGCATCGCGGCCGATCC
CGACAATCCGGAATGGACCGAAGCGGACTTTCGAAGCGCCGTGCCCTTCGAACAGGCCTTTCCCGTCCTCGCAGAGAAAC
TGCGCCGCACCCGCGGCCCCCAAAGCGCTCCGACCAAACAGCTCGTCAGCTTGAGGCTCGATCAGGACGTCCTGCTTCGT
TTCAGGGCGACCGGTCCGGGCTGGCAGTCTCGGATGAACGAAGCCCTGCGCCGGGCCGCGGCCGATCTTCCCGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Z2MSV0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A432DGX8 |