Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafN(antitoxin) |
| Location | 1290777..1291342 | Replicon | chromosome |
| Accession | NZ_CP082307 | ||
| Organism | Vibrio alginolyticus strain HNV2 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | K6748_RS06070 | Protein ID | WP_039485476.1 |
| Coordinates | 1291055..1291342 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | K6748_RS06065 | Protein ID | WP_238958970.1 |
| Coordinates | 1290777..1291058 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6748_RS06015 (K6748_06020) | 1286774..1287046 | + | 273 | WP_005462157.1 | nicotinamide mononucleotide transporter | - |
| K6748_RS06020 (K6748_06025) | 1287021..1287167 | + | 147 | WP_080277001.1 | DUF3265 domain-containing protein | - |
| K6748_RS06025 (K6748_06030) | 1287195..1287545 | + | 351 | WP_140134588.1 | hypothetical protein | - |
| K6748_RS06030 (K6748_06035) | 1287572..1287664 | + | 93 | WP_171345234.1 | DUF3265 domain-containing protein | - |
| K6748_RS06035 (K6748_06040) | 1287732..1288268 | + | 537 | WP_029793274.1 | hypothetical protein | - |
| K6748_RS06040 (K6748_06045) | 1288333..1288425 | + | 93 | WP_079757247.1 | DUF3265 domain-containing protein | - |
| K6748_RS06045 (K6748_06050) | 1288458..1289252 | + | 795 | WP_138939280.1 | hypothetical protein | - |
| K6748_RS06050 (K6748_06055) | 1289402..1289944 | + | 543 | WP_238958969.1 | GNAT family N-acetyltransferase | - |
| K6748_RS06055 | 1289941..1290006 | + | 66 | Protein_1111 | DUF3265 domain-containing protein | - |
| K6748_RS06060 (K6748_06060) | 1290095..1290577 | + | 483 | WP_213885666.1 | MazG-related protein | - |
| K6748_RS06065 (K6748_06065) | 1290777..1291058 | + | 282 | WP_238958970.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| K6748_RS06070 (K6748_06070) | 1291055..1291342 | + | 288 | WP_039485476.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K6748_RS06075 (K6748_06075) | 1291588..1291932 | + | 345 | WP_205461624.1 | antibiotic biosynthesis monooxygenase | - |
| K6748_RS06080 (K6748_06080) | 1291958..1292050 | + | 93 | WP_140129053.1 | DUF3265 domain-containing protein | - |
| K6748_RS06085 (K6748_06085) | 1292077..1292391 | + | 315 | WP_238958971.1 | hypothetical protein | - |
| K6748_RS06090 (K6748_06090) | 1292530..1292991 | + | 462 | WP_140372779.1 | GNAT family N-acetyltransferase | - |
| K6748_RS06095 (K6748_06095) | 1293478..1293567 | + | 90 | WP_079766076.1 | DUF3265 domain-containing protein | - |
| K6748_RS06100 (K6748_06100) | 1294172..1295539 | + | 1368 | WP_205461630.1 | hypothetical protein | - |
| K6748_RS06105 (K6748_06105) | 1295567..1295659 | + | 93 | WP_074546604.1 | DUF3265 domain-containing protein | - |
| K6748_RS06110 (K6748_06110) | 1295687..1296184 | + | 498 | WP_045487922.1 | GNAT family N-acetyltransferase | - |
| K6748_RS06115 (K6748_06115) | 1296199..1296291 | + | 93 | WP_196297913.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1272150..1350709 | 78559 | |
| - | inside | Integron | - | - | 1272667..1340786 | 68119 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11011.68 Da Isoelectric Point: 5.1098
>T214539 WP_039485476.1 NZ_CP082307:1291055-1291342 [Vibrio alginolyticus]
MKVVWSPLALQKLGDAAEFISLDNPSAAEKWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQMLSEDDV
MKVVWSPLALQKLGDAAEFISLDNPSAAEKWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQMLSEDDV
Download Length: 288 bp
>T214539 NZ_CP110130:c2811602-2811300 [Methylorubrum extorquens]
ATGCTGGAGATCATCCGCACCCGAACGTTCGCGGATTGGCTCAAGGGGCTTCGGGACGATCGCGCAAAGGCACGGATCGC
GTTGCGGATCGATCGCCTCGCACTCGGCCATGAGGGTGATTCGAAAGCTGTCGGCGGTGGCGTCAGCGAGTTGCGGATCG
ACTACGGACCGGGCTACCGGATCTACTTCACGTATCGTGGCAAGACCCTGGTCGTCCTGCTGTGCGGCGGGGACAAGGCG
AGCCAGAAGCGCGACATTTCCCGAGCGAAGACCTTGGCGACGATGCTGGACGGAACGGAATGA
ATGCTGGAGATCATCCGCACCCGAACGTTCGCGGATTGGCTCAAGGGGCTTCGGGACGATCGCGCAAAGGCACGGATCGC
GTTGCGGATCGATCGCCTCGCACTCGGCCATGAGGGTGATTCGAAAGCTGTCGGCGGTGGCGTCAGCGAGTTGCGGATCG
ACTACGGACCGGGCTACCGGATCTACTTCACGTATCGTGGCAAGACCCTGGTCGTCCTGCTGTGCGGCGGGGACAAGGCG
AGCCAGAAGCGCGACATTTCCCGAGCGAAGACCTTGGCGACGATGCTGGACGGAACGGAATGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10458.96 Da Isoelectric Point: 5.8650
>AT214539 WP_238958970.1 NZ_CP082307:1290777-1291058 [Vibrio alginolyticus]
MSRIHFDQDIQPLSEFRAGVTSYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARTQVLGRIKK
MSRIHFDQDIQPLSEFRAGVTSYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARTQVLGRIKK
Download Length: 282 bp
>AT214539 NZ_CP110130:c2811303-2811010 [Methylorubrum extorquens]
ATGATGACGGAAACCAGCCCCTACGACTCGGCCGAATTCCTGGAAAGCGATGAGGCGGTTGCCGAGTATCTGGCTGCGGC
CATCGAAGAAGGAGACGCTGCGCTGTTTCGCCGGGCGCTCGGTGTCGCGGCCCGCGCGCGTGGCATGACCCAGATCGCTC
GGGAGACAGGTTTATCGCGGGAAAGCCTCTATCGGGCGTTGTCGGACGACGGCAACCCGAGCCTCGACACGGCTCTGCGC
GTCCTGAATGCCTTGAACGTCCGCCTGACGGCATCGGTCGCCTCTCCTCAGTGA
ATGATGACGGAAACCAGCCCCTACGACTCGGCCGAATTCCTGGAAAGCGATGAGGCGGTTGCCGAGTATCTGGCTGCGGC
CATCGAAGAAGGAGACGCTGCGCTGTTTCGCCGGGCGCTCGGTGTCGCGGCCCGCGCGCGTGGCATGACCCAGATCGCTC
GGGAGACAGGTTTATCGCGGGAAAGCCTCTATCGGGCGTTGTCGGACGACGGCAACCCGAGCCTCGACACGGCTCTGCGC
GTCCTGAATGCCTTGAACGTCCGCCTGACGGCATCGGTCGCCTCTCCTCAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|