Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1944299..1944846 Replicon chromosome
Accession NZ_CP082303
Organism Vibrio alginolyticus strain FJV2

Toxin (Protein)


Gene name relE Uniprot ID A0A7Y0S5Y1
Locus tag K6745_RS08925 Protein ID WP_025796191.1
Coordinates 1944299..1944601 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag K6745_RS08930 Protein ID WP_005448240.1
Coordinates 1944589..1944846 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6745_RS08860 (K6745_08815) 1939454..1939543 - 90 WP_080101990.1 DUF3265 domain-containing protein -
K6745_RS08865 (K6745_08820) 1939570..1939929 - 360 WP_115386112.1 hypothetical protein -
K6745_RS08870 (K6745_08825) 1940434..1940525 - 92 Protein_1722 DUF3265 domain-containing protein -
K6745_RS08875 (K6745_08830) 1940540..1940887 - 348 WP_031780756.1 hypothetical protein -
K6745_RS08880 (K6745_08835) 1941530..1941835 - 306 WP_229636740.1 GFA family protein -
K6745_RS08885 (K6745_08840) 1941996..1942088 - 93 WP_080256826.1 DUF3265 domain-containing protein -
K6745_RS08890 (K6745_08845) 1942103..1942501 - 399 WP_025519062.1 DUF6232 family protein -
K6745_RS08895 (K6745_08850) 1942638..1942940 - 303 WP_054730763.1 hypothetical protein -
K6745_RS08900 (K6745_08855) 1942980..1943072 - 93 WP_238966170.1 DUF3265 domain-containing protein -
K6745_RS08905 (K6745_08860) 1943087..1943737 - 651 WP_238966171.1 hypothetical protein -
K6745_RS08910 (K6745_08865) 1943764..1943856 - 93 WP_238966172.1 DUF3265 domain-containing protein -
K6745_RS08915 (K6745_08870) 1943879..1944142 - 264 WP_005448110.1 hypothetical protein -
K6745_RS08920 (K6745_08875) 1944164..1944263 - 100 Protein_1732 DUF3265 domain-containing protein -
K6745_RS08925 (K6745_08880) 1944299..1944601 - 303 WP_025796191.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6745_RS08930 (K6745_08885) 1944589..1944846 - 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6745_RS08935 1944928..1945057 - 130 Protein_1735 DUF3265 domain-containing protein -
K6745_RS08940 (K6745_08890) 1945476..1945568 - 93 WP_078555087.1 DUF3265 domain-containing protein -
K6745_RS08945 (K6745_08895) 1945589..1946098 - 510 WP_047104052.1 hypothetical protein -
K6745_RS08950 (K6745_08900) 1946206..1946316 - 111 Protein_1738 DUF3265 domain-containing protein -
K6745_RS08955 (K6745_08905) 1946701..1946793 - 93 WP_079858632.1 DUF3265 domain-containing protein -
K6745_RS08960 (K6745_08910) 1946813..1947235 - 423 WP_069499572.1 hypothetical protein -
K6745_RS08965 1947316..1947399 - 84 Protein_1741 DUF3265 domain-containing protein -
K6745_RS08970 (K6745_08915) 1947369..1947779 - 411 WP_031781297.1 cytidine deaminase -
K6745_RS08975 (K6745_08920) 1947821..1947910 - 90 WP_080619587.1 DUF3265 domain-containing protein -
K6745_RS08980 (K6745_08925) 1947935..1948270 - 336 WP_238966173.1 TonB family protein -
K6745_RS08985 (K6745_08930) 1948299..1948388 - 90 WP_072615037.1 DUF3265 domain-containing protein -
K6745_RS08990 (K6745_08935) 1948881..1949327 - 447 WP_025527220.1 GNAT family N-acetyltransferase -
K6745_RS08995 (K6745_08940) 1949356..1949445 - 90 WP_079771093.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1919303..1959226 39923
- inside Integron - - 1928581..1956613 28032


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11655.54 Da        Isoelectric Point: 5.1765

>T214538 WP_025796191.1 NZ_CP082303:c1944601-1944299 [Vibrio alginolyticus]
MAEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T214538 NZ_CP110130:c2811303-2811010 [Methylorubrum extorquens]
ATGATGACGGAAACCAGCCCCTACGACTCGGCCGAATTCCTGGAAAGCGATGAGGCGGTTGCCGAGTATCTGGCTGCGGC
CATCGAAGAAGGAGACGCTGCGCTGTTTCGCCGGGCGCTCGGTGTCGCGGCCCGCGCGCGTGGCATGACCCAGATCGCTC
GGGAGACAGGTTTATCGCGGGAAAGCCTCTATCGGGCGTTGTCGGACGACGGCAACCCGAGCCTCGACACGGCTCTGCGC
GTCCTGAATGCCTTGAACGTCCGCCTGACGGCATCGGTCGCCTCTCCTCAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT214538 WP_005448240.1 NZ_CP082303:c1944846-1944589 [Vibrio alginolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT214538 NZ_CP110130:c2811602-2811300 [Methylorubrum extorquens]
ATGCTGGAGATCATCCGCACCCGAACGTTCGCGGATTGGCTCAAGGGGCTTCGGGACGATCGCGCAAAGGCACGGATCGC
GTTGCGGATCGATCGCCTCGCACTCGGCCATGAGGGTGATTCGAAAGCTGTCGGCGGTGGCGTCAGCGAGTTGCGGATCG
ACTACGGACCGGGCTACCGGATCTACTTCACGTATCGTGGCAAGACCCTGGTCGTCCTGCTGTGCGGCGGGGACAAGGCG
AGCCAGAAGCGCGACATTTCCCGAGCGAAGACCTTGGCGACGATGCTGGACGGAACGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y0S5Y1

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References