Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1929167..1929726 Replicon chromosome
Accession NZ_CP082303
Organism Vibrio alginolyticus strain FJV2

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag K6745_RS08790 Protein ID WP_005398411.1
Coordinates 1929448..1929726 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag K6745_RS08785 Protein ID WP_005398409.1
Coordinates 1929167..1929451 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6745_RS08740 (K6745_08700) 1924607..1925167 - 561 WP_025768088.1 sugar O-acetyltransferase -
K6745_RS08745 (K6745_08705) 1925299..1925640 - 342 WP_238966331.1 RDD family protein -
K6745_RS08750 (K6745_08710) 1925854..1926462 - 609 WP_005389306.1 pyridoxamine 5'-phosphate oxidase family protein -
K6745_RS08755 (K6745_08715) 1926606..1927007 - 402 WP_005377076.1 DUF2007 domain-containing protein -
K6745_RS08760 (K6745_08720) 1927112..1927633 - 522 WP_005377075.1 GNAT family N-acetyltransferase -
K6745_RS08765 (K6745_08725) 1927901..1928380 + 480 WP_021033918.1 hypothetical protein -
K6745_RS08770 1928440..1928574 - 135 WP_005377070.1 DUF3265 domain-containing protein -
K6745_RS08775 (K6745_08730) 1928581..1928967 - 387 WP_230623518.1 hydrolase -
K6745_RS08780 (K6745_08735) 1929000..1929090 - 91 Protein_1704 DUF3265 domain-containing protein -
K6745_RS08785 (K6745_08740) 1929167..1929451 + 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K6745_RS08790 (K6745_08745) 1929448..1929726 + 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
K6745_RS08795 (K6745_08750) 1929755..1929847 - 93 WP_080276993.1 DUF3265 domain-containing protein -
K6745_RS08800 (K6745_08755) 1929882..1930283 - 402 WP_238966165.1 HIT family protein -
K6745_RS08805 (K6745_08760) 1930316..1930408 - 93 WP_201769224.1 DUF3265 domain-containing protein -
K6745_RS08810 (K6745_08765) 1930447..1931115 - 669 WP_025769008.1 hypothetical protein -
K6745_RS08815 (K6745_08770) 1931280..1931996 - 717 WP_025769009.1 DUF5677 domain-containing protein -
K6745_RS08820 (K6745_08775) 1932023..1932115 - 93 WP_079751658.1 DUF3265 domain-containing protein -
K6745_RS08825 (K6745_08780) 1932138..1933043 - 906 WP_148299896.1 Imm49 family immunity protein -
K6745_RS08830 (K6745_08785) 1933820..1934032 - 213 WP_025553613.1 hypothetical protein -
K6745_RS08835 (K6745_08790) 1934386..1934709 - 324 WP_238966166.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1919303..1959226 39923
- inside Integron - - 1928581..1956613 28032


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T214537 WP_005398411.1 NZ_CP082303:1929448-1929726 [Vibrio alginolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T214537 NZ_CP110130:1338005-1338502 [Methylorubrum extorquens]
GTGAGCCAGTCGCTCTGGCGGATCGGGACCGACGCTCGGACATACACTGCCGACGACCTGTCGGGGACCGGGGCCAAGCT
CTCCGGCGGCCGATGGAACGCCGTCGGCGTCGCCCTGGTCTACGCGGCGGGCAGTCGTGCCCTCGCCTGCCTCGAAACCT
TCGTCCACCTCAATGCCGGCGGCCTGCCGTTGAACCGATACCTCGTCGAAATCGACGTGCCGGATGAGGTCTGGGCGTCG
GCCGAACGCGCGACCCCGGACACGCTGCCCGTTGGCTGGGACGCCGAGCCGGCGGGTCTCGTCAGCCTCGCCTTCGGCAC
GGATTGGGCGAACGGAAATCGGTCGGCGCTTCTGCTGGTCCCCTCCGTCATCGTGCCGGAGGAGCAGAATGCCCTCATCA
ATCCCACCCATCCCGACGCGGCGAAAATCACGGCACGCAAGGTTCGCAAGTGGCTCTACGATCCGCGCCTCGACCGCGAC
CGAGGTCCCTTCGCGTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT214537 WP_005398409.1 NZ_CP082303:1929167-1929451 [Vibrio alginolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT214537 NZ_CP110130:1337517-1338008 [Methylorubrum extorquens]
ATGCCGGACACGATGATCAAGGCCCCGGCCAAGCGGAGAAAGCCGCACGGGCCGGGGGCACGACCCTTCGCCTATCTCGA
CCTCTACCGCGCCTCCCCCTTCGACCGCATCGAGGTCATCAAGGCGGGGGTGCCCGCAAGGGCGGTCAAGGGTTTCATCA
CGGCGCTGTGCCTCGACCAGCAGGTGATGTTCGACGCCCTCAACCTGAAGACGGCCACGGTGAACAAGAAGGCGGCCCGG
GACGAAGCACTGTCGTCCGAGGACAGCGAGCGGGTCGTCGGCCTCGCCAAGCTCGTCGGGCAGCTCGAAGCGATGATCGA
GGAATCCGGCGCGACGAAGGATTTCGACGCGCCGGGATGGCTCTCGCGTTGGCTGCGCGAGCCCTTGCCGGCGCTGGGCG
GCGGCAAGCCGCTCGACCTCCTCGACACGATGGAGGGCCAAGCTCTGGTGTCGCGCGCGCTGGCGCAGATCCAGAGCGGA
GCCTATGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR22

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References