Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 82400..83043 Replicon plasmid p1_CQ10
Accession NZ_CP082293
Organism Pantoea agglomerans strain CQ10

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag K6R05_RS18855 Protein ID WP_161736537.1
Coordinates 82400..82816 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag K6R05_RS18860 Protein ID WP_110332107.1
Coordinates 82813..83043 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6R05_RS18825 (K6R05_18825) 77814..78416 - 603 WP_161736542.1 helix-turn-helix transcriptional regulator -
K6R05_RS18830 (K6R05_18830) 78460..79155 + 696 WP_222925611.1 B3/4 domain-containing protein -
K6R05_RS18835 (K6R05_18835) 79271..79591 + 321 WP_222925612.1 hypothetical protein -
K6R05_RS22185 79823..80143 + 321 WP_262390927.1 hypothetical protein -
K6R05_RS22190 80288..80551 + 264 WP_262390928.1 DUF1173 domain-containing protein -
K6R05_RS18845 (K6R05_18845) 80699..81157 + 459 WP_222925641.1 hypothetical protein -
K6R05_RS18850 (K6R05_18850) 81151..81444 + 294 WP_222925613.1 DUF1493 family protein -
K6R05_RS18855 (K6R05_18855) 82400..82816 - 417 WP_161736537.1 type II toxin-antitoxin system VapC family toxin Toxin
K6R05_RS18860 (K6R05_18860) 82813..83043 - 231 WP_110332107.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K6R05_RS18865 (K6R05_18865) 83539..84837 - 1299 WP_222925614.1 NtaA/DmoA family FMN-dependent monooxygenase -
K6R05_RS18870 (K6R05_18870) 84815..86050 - 1236 WP_222925615.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
K6R05_RS18875 (K6R05_18875) 86200..87324 - 1125 WP_222925616.1 ATP-grasp domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..235469 235469


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-42)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15045.26 Da        Isoelectric Point: 6.7031

>T214533 WP_161736537.1 NZ_CP082293:c82816-82400 [Pantoea agglomerans]
VNTTYMLDTCICSFIMREQPEAVLKRLEQAVMRGHRIVVSAITYSEMRFGATGPKASPRHAQLVDAFCARLDAVLPWDRA
AVDATTEIKVALRQAGTSIGPNDTAIAGHAISAGAVLVTNNTREFARVPDLALEDWVY

Download         Length: 417 bp

>T214533 NZ_CP110128:c5452435-5451362 [Pseudomonas sp. WJP1]
GTGACTGACCGCACCTACAAAGACATCAACCTGAACCGAGCCATCATCGAGGAAACGATTGTCCGCTTTGTCGATGTCAA
TGGAATCAAGCTGAGGGGAATTGGCGAAAAGCCGGGCAGCCCTGGCATTCGTGTAGGTATTGGGAGTGCAGGTATTGAGG
ATGCAACGGTTGAAATTTTCTTCAACAACACAGGTACGTCCACTCTCCACTACAAGCTGGGGAAGAACCAAGAGCTTGGA
CAGAAGCTAGCCGATGCTCTCTATGAAACGATCCACCCAGATGACTTTGTAACGATCAATCTTGGCATCAAAGGAATAGA
TCTATCTGATGCCCAAGCACTGATCAAAGAGCTCACCGAGTCAGTCAATGCAGACATTGAGGTGGCTTCGTACACCAAGG
GTGAGCGACGGAATATCTGGAAACTCAAGTCTAAGAAAAATTCTGACGAGTTGACCGTTACTCAACACGAGACCACCAAC
AAGCTACAGCTCCAAGGCCGCCCACTCAGTTGCTATCGGGAGTTGAGCTACCTGCTCACCGAGATCCTGGAGGTCAACGC
ACTCGAGTGTATCCTATTTAAAAAGGAAGAAAATCGTTCCGAGTTCGTCTGTACCGAGGTCGCCGAGAGCGTTCTCAAGG
ATAGGTTTGGAACCTGCTTCGAAAATCTACCGGTGGCAACCCGAAAGCTGCTTCTGGCAAGCCTCTGCGTTAGACTGGCA
AGCCCGGCGCTGCCTGACTACTGCATGCTCGTTTACCCAGAGCTCCGCTCCCTCGAGGGCGCAATCAAACATAAGCTGTC
TGAAAAAAATCTTTCGAATCAGGAGGATAGCTTCGGCGGCTTTTTTACCAAGACCAGTGGTCAGTTCAATCTTAAGCAGC
AATATCAGGCTGACGTCAACGATGCTAAACTTCAGAGTGTTTTGGGCGATGCTTACACGTTCTTCAATAAGCATCGACAC
GGTTTGTTCCACATGGAAGAGATGCCTTCCGCAAGCCGTATGATTAGCAGCATCACTCAAGCTGTGGCATTGTGTGATGA
AGCTTACGCCCACCTCAAGACTCTGTATGGTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8785.89 Da        Isoelectric Point: 4.3775

>AT214533 WP_110332107.1 NZ_CP082293:c83043-82813 [Pantoea agglomerans]
MRTVSIFKNGNNRAIRLPRDMDFEGVSELEIIREGDSIILRPARPTWGSYLELEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT214533 NZ_CP110128:c5451307-5451014 [Pseudomonas sp. WJP1]
ATGACGGTAGTGACCGCTACCAGTTATGAGAACCCCTTATCTAGTCTTTCTGCAATTGCTAGTATGATGCGGAATACAAG
TCACACTGGCAAGGAAATTGTATTATTCGATCTTCTCTGCTCAAACGGCGAAGAATGGAATCGTTTTGCCTTCATTAATT
ACAACGGCACCGACTTTGAAAGAAGTACATTCAGCATTGTTTCAAGGTGCGACATTCCTTCTGATCTTATAGAAACACAA
ACTCGCTTTTTTGAAGTTCATCCTGAGTATCTGCGTGATTCTGTATTGAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References