Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2151874..2152504 Replicon chromosome
Accession NZ_CP082292
Organism Pantoea agglomerans strain CQ10

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag K6R05_RS10005 Protein ID WP_262390861.1
Coordinates 2152223..2152504 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K6R05_RS10000 Protein ID WP_161732427.1
Coordinates 2151874..2152230 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6R05_RS09990 (K6R05_09990) 2147486..2148640 + 1155 WP_222924065.1 efflux RND transporter periplasmic adaptor subunit -
K6R05_RS09995 (K6R05_09995) 2148653..2151805 + 3153 WP_222924066.1 multidrug efflux RND transporter permease subunit OqxB -
K6R05_RS10000 (K6R05_10000) 2151874..2152230 - 357 WP_161732427.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K6R05_RS10005 (K6R05_10005) 2152223..2152504 - 282 WP_262390861.1 type II toxin-antitoxin system HicA family toxin Toxin
K6R05_RS10010 (K6R05_10010) 2152656..2153150 - 495 WP_161732429.1 Rrf2 family transcriptional regulator -
K6R05_RS10015 (K6R05_10015) 2153358..2154542 - 1185 WP_222924068.1 MFS transporter -
K6R05_RS10020 (K6R05_10020) 2154745..2155674 + 930 WP_222924069.1 DNA replication terminus site-binding protein -
K6R05_RS10025 (K6R05_10025) 2155717..2157114 - 1398 WP_222924070.1 class II fumarate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-79)

Antitoxin

Uncharacterised protein family HicB

(59-111)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10677.26 Da        Isoelectric Point: 10.7784

>T214530 WP_262390861.1 NZ_CP082292:c2152504-2152223 [Pantoea agglomerans]
MNTVVRDLRKKQRETLEQVFQMPPPSGLKWQAVESLIRALGGEIKEGSGSRVRFLLRGRIARFHRPHPSPDTDRGAVINL
REWLESIGVDPYE

Download         Length: 282 bp

>T214530 NZ_CP110128:c3768498-3768199 [Pseudomonas sp. WJP1]
ATGAAGACAATCAAACAAACAGCGACCTACATGACGTGGGAGCGAAAACTAAAGGACCAGCGCGCCAAAGCCGCAATTGC
CGCGCGGATCTTTCGGTTGGCAAACGGTTTGTTGGGTGACGTGTCGCCGGTAGGCCAGGGGGTCAGCGAGTTACGGATTC
ACTATGGCCCCGGTTACCGCGTATATTTTCAGCAACGAGGTGATGAATTTGTGTTGCTGTTGTGCGGCGGCGATAAAAGC
AGTCAAAGCCGTGATATTGAAGCAGCAAAAATACTCGCCAGCGAGTGGAGGTCAGAATGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13291.93 Da        Isoelectric Point: 5.1987

>AT214530 WP_161732427.1 NZ_CP082292:c2152230-2151874 [Pantoea agglomerans]
MNNRSNSSITVAGQPAVITYVPELHMFRGRFTGLSGYCDFVSDSVQGLYKEGEISLREYLEDCAASGINPYAEQEKIKTF
TLRYPESMGERLSQAAAQNETSLNAFIIETLNERLKRR

Download         Length: 357 bp

>AT214530 NZ_CP110128:c3768202-3767906 [Pseudomonas sp. WJP1]
ATGAGCGAAAAAATTTACGACTACGACCCAGCAGCAGCCCTGGACGGCCCCGAAGCAATCGCCGTCTTCATGGCGGATGC
GTTTGAGACGGGTAATGCTGAATACATCGCCAAGGCAATGGGGGTCGTTGCCCGAGCCAAAGGCATGACTGAGCTGGCCC
GCGAAACAGGGCTTTCCCGTGAGCAGCTTTATCGCTCATTCAGCGAAGACGGGAATCCCACGCTTAAAACCATGCTGGCC
GTTATGCGTGCCCTGGGTATCGACATGACCGCTCGACCGCACGTATCACCGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References