Detailed information of TA system TA214529

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2051039..2052600
• Replicon: chromosome
• Accession: NZ_CP082292
• Organism: Pantoea agglomerans strain CQ10

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: K6R05_RS09530
• Protein ID: WP_161734778.1
• Coordinates: 2051287..2052600 (+)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: K6R05_RS09525
• Protein ID: WP_161734780.1
• Coordinates: 2051039..2051287 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6R05_RS09505 (K6R05_09505)	2046289..2048514	+	2226	WP_222924024.1	iron ABC transporter permease	-
K6R05_RS09510 (K6R05_09510)	2048511..2049572	+	1062	WP_161734788.1	ABC transporter ATP-binding protein	-
K6R05_RS09515 (K6R05_09515)	2049596..2050387	+	792	WP_161734785.1	inositol monophosphatase family protein	-
K6R05_RS09520 (K6R05_09520)	2050421..2050858	-	438	WP_161734783.1	GNAT family N-acetyltransferase	-
K6R05_RS09525 (K6R05_09525)	2051039..2051287	+	249	WP_161734780.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
K6R05_RS09530 (K6R05_09530)	2051287..2052600	+	1314	WP_161734778.1	type II toxin-antitoxin system HipA family toxin	Toxin
K6R05_RS09535 (K6R05_09535)	2052737..2052910	+	174	WP_262390859.1	type II toxin-antitoxin system MqsA family antitoxin	-
K6R05_RS09540 (K6R05_09540)	2053080..2054462	+	1383	WP_222924025.1	M24 family metallopeptidase	-
K6R05_RS09545 (K6R05_09545)	2054577..2056622	+	2046	WP_222924026.1	FUSC family protein	-
K6R05_RS09550 (K6R05_09550)	2056996..2057331	-	336	WP_161734767.1	gamma-glutamylcyclotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-100)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49187.79 Da
• Isoelectric Point: 9.1315

>T214529 WP_161734778.1 NZ_CP082292:2051287-2052600 [Pantoea agglomerans]
MQRLIAWMNGERVGVLTRQRNGAHEFQYDTGWLSNPLSRPLSLSLPLQVKAITSHAVINFFDNLLPDSPLIRDRIVARYQ
IKSRQPFDLLQEVGRDSVGATMLLPPDMPLPALQARYEVLDEARLESVLSAYQSDIPLGMLREETDFRISVAGAQEKTAL
LLTEEGWSIPAGATPTSHIIKLPIGEIKQPAATLDMRESVENEYLCLALARALGIDVPQATIIRAGKMRALAVERFDRRW
SRDRTRLIRLPQEDFCQALGLPSSTKYASDGGPGIAEIMQILMGSSNAIEDRYRFMMFQVFQWLIGATDGHAKNFSLFIE
RGGSYRLTPFYDVISAYPVLGGTGLNRRALKLAMGLRATKGKKTEIDKIFPRHFIATAKSVSFDRDSLQQIFDFFVREFP
KAVVSVREALPADYPQHIADAIFSHSLIMLERLRHKE

Nucleotide

• Length: 1314 bp

>T214529 NZ_CP110128:c3768202-3767906 [Pseudomonas sp. WJP1]
ATGAGCGAAAAAATTTACGACTACGACCCAGCAGCAGCCCTGGACGGCCCCGAAGCAATCGCCGTCTTCATGGCGGATGC
GTTTGAGACGGGTAATGCTGAATACATCGCCAAGGCAATGGGGGTCGTTGCCCGAGCCAAAGGCATGACTGAGCTGGCCC
GCGAAACAGGGCTTTCCCGTGAGCAGCTTTATCGCTCATTCAGCGAAGACGGGAATCCCACGCTTAAAACCATGCTGGCC
GTTATGCGTGCCCTGGGTATCGACATGACCGCTCGACCGCACGTATCACCGTTGTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9246.55 Da
• Isoelectric Point: 5.6579

>AT214529 WP_161734780.1 NZ_CP082292:2051039-2051287 [Pantoea agglomerans]
MIYSPLQLANRLKLIRQRNGWTQSELAKKVGLKQATISHFENAPDTTSLATLFKLLQALEVSLDVVEKEEASAPQLHDED
AW

Nucleotide

• Length: 249 bp

>AT214529 NZ_CP110128:c3768498-3768199 [Pseudomonas sp. WJP1]
ATGAAGACAATCAAACAAACAGCGACCTACATGACGTGGGAGCGAAAACTAAAGGACCAGCGCGCCAAAGCCGCAATTGC
CGCGCGGATCTTTCGGTTGGCAAACGGTTTGTTGGGTGACGTGTCGCCGGTAGGCCAGGGGGTCAGCGAGTTACGGATTC
ACTATGGCCCCGGTTACCGCGTATATTTTCAGCAACGAGGTGATGAATTTGTGTTGCTGTTGTGCGGCGGCGATAAAAGC
AGTCAAAGCCGTGATATTGAAGCAGCAAAAATACTCGCCAGCGAGTGGAGGTCAGAATGA