Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | stbDE/ParE-YafN |
| Location | 234408..234930 | Replicon | plasmid pKp6001 |
| Accession | NZ_CP082291 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain Kp6 | ||
Toxin (Protein)
| Gene name | stbE | Uniprot ID | A0A7H0EVH6 |
| Locus tag | K6T93_RS26485 | Protein ID | WP_014839901.1 |
| Coordinates | 234646..234930 (+) | Length | 95 a.a. |
Antitoxin (Protein)
| Gene name | stbD | Uniprot ID | A0A7H0EVH5 |
| Locus tag | K6T93_RS26480 | Protein ID | WP_014839900.1 |
| Coordinates | 234408..234656 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6T93_RS26455 (K6T93_26455) | 229586..229942 | + | 357 | WP_017901071.1 | hypothetical protein | - |
| K6T93_RS26460 (K6T93_26460) | 230316..230714 | + | 399 | WP_014839899.1 | H-NS family nucleoid-associated regulatory protein | - |
| K6T93_RS26465 (K6T93_26465) | 230851..231459 | + | 609 | WP_024266306.1 | DUF2913 family protein | - |
| K6T93_RS26470 (K6T93_26470) | 232003..232635 | + | 633 | WP_001567369.1 | hypothetical protein | - |
| K6T93_RS26475 (K6T93_26475) | 232664..234067 | - | 1404 | WP_001567368.1 | ISNCY-like element ISKpn21 family transposase | - |
| K6T93_RS26480 (K6T93_26480) | 234408..234656 | + | 249 | WP_014839900.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| K6T93_RS26485 (K6T93_26485) | 234646..234930 | + | 285 | WP_014839901.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K6T93_RS26490 (K6T93_26490) | 235121..235597 | + | 477 | WP_042934526.1 | hypothetical protein | - |
| K6T93_RS26495 (K6T93_26495) | 235603..236280 | + | 678 | WP_042934501.1 | hypothetical protein | - |
| K6T93_RS26500 (K6T93_26500) | 236297..237016 | - | 720 | WP_042934502.1 | cation:proton antiporter | - |
| K6T93_RS26505 (K6T93_26505) | 237257..237859 | - | 603 | WP_014839902.1 | HAD domain-containing protein | - |
| K6T93_RS26510 (K6T93_26510) | 237856..238377 | - | 522 | WP_048336588.1 | hypothetical protein | - |
| K6T93_RS26515 (K6T93_26515) | 238458..239402 | - | 945 | WP_014839903.1 | DsbA family protein | - |
| K6T93_RS26520 (K6T93_26520) | 239465..239674 | - | 210 | WP_125316032.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaSHV-12 / blaSFO-1 / qnrS1 / aac(6')-Ib-cr / ARR-3 / blaTEM-1B / blaCTX-M-3 / msr(E) / mph(E) / dfrA1 / aadA5 / qacE / sul1 / armA / catA2 / aac(3)-IId | - | 1..337329 | 337329 | |
| - | flank | IS/Tn | - | - | 232664..234067 | 1403 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 10866.46 Da Isoelectric Point: 10.5831
>T214527 WP_014839901.1 NZ_CP082291:234646-234930 [Klebsiella pneumoniae subsp. pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLSERLQNPRVPAAQLHGGKDQYKIKLHGAGYRLVYSVNDEIVTVTVIGVGK
RNNDDIYNATRHRN
MTYKLAFNESALKEWKKLGHTIREQFKKKLSERLQNPRVPAAQLHGGKDQYKIKLHGAGYRLVYSVNDEIVTVTVIGVGK
RNNDDIYNATRHRN
Download Length: 285 bp
>T214527 NZ_CP110128:1781509-1781721 [Pseudomonas sp. WJP1]
GTGCAAAGCAGGCTATTGATCAAGGAATTGATGGAGGCGGGTTGGGCCCTGGACCGGGTCACTGGCAGTCATCACATCTT
CACCCACCGTTACAACCCGTACACCATTCCCGTTCCCCATCCGAAAAAGGATTTGCCGGTCGGGACGGTCAAGAGCATCA
GGAGGCGAGCCGGGCTGTACTGCCCGCCAGCCAGTTACGCAGGAGATCCATAA
GTGCAAAGCAGGCTATTGATCAAGGAATTGATGGAGGCGGGTTGGGCCCTGGACCGGGTCACTGGCAGTCATCACATCTT
CACCCACCGTTACAACCCGTACACCATTCCCGTTCCCCATCCGAAAAAGGATTTGCCGGTCGGGACGGTCAAGAGCATCA
GGAGGCGAGCCGGGCTGTACTGCCCGCCAGCCAGTTACGCAGGAGATCCATAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9071.29 Da Isoelectric Point: 3.8832
>AT214527 WP_014839900.1 NZ_CP082291:234408-234656 [Klebsiella pneumoniae subsp. pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMEMLEDQELGRIADERIGEDRIEVNID
DL
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMEMLEDQELGRIADERIGEDRIEVNID
DL
Download Length: 249 bp
>AT214527 NZ_CP110128:1781721-1782125 [Pseudomonas sp. WJP1]
ATGCAATATCCAATCTGTATCGAATGGGGCGATGAGAACACCGCCATCGGTATCCAGATCCCCGATATCCCAGGTGCGGT
AACCGCCGGGGATAGCTTTGAAGAGGCCTACAACGCAGCCGTCGAGATTGCCCACATCATGCTGCAGGAATTGGCGGCGG
ATGGCGAGCCGATTCCGATGCCGACTTCGGCTTCGGTGCATCGCAGTAATCCCGAGTTCGCCGACATGGGCTGGGGCATG
CTGGAGCTGGACATCTCGCCGTACCTGGGCAAGACCGAGAAGGTCAACGTGACGTTGCCTGGCTATGTGATCCAGCGCAT
TGACCGTTATGTGCGCGAGCACAATGTCAAAAGCCGGTCGTCGTTCCTGGCGGATGCGGCGATGGAGAAACTGGTGCGCA
ATTGA
ATGCAATATCCAATCTGTATCGAATGGGGCGATGAGAACACCGCCATCGGTATCCAGATCCCCGATATCCCAGGTGCGGT
AACCGCCGGGGATAGCTTTGAAGAGGCCTACAACGCAGCCGTCGAGATTGCCCACATCATGCTGCAGGAATTGGCGGCGG
ATGGCGAGCCGATTCCGATGCCGACTTCGGCTTCGGTGCATCGCAGTAATCCCGAGTTCGCCGACATGGGCTGGGGCATG
CTGGAGCTGGACATCTCGCCGTACCTGGGCAAGACCGAGAAGGTCAACGTGACGTTGCCTGGCTATGTGATCCAGCGCAT
TGACCGTTATGTGCGCGAGCACAATGTCAAAAGCCGGTCGTCGTTCCTGGCGGATGCGGCGATGGAGAAACTGGTGCGCA
ATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7H0EVH6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7H0EVH5 |