Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 5077916..5078541 | Replicon | chromosome |
Accession | NZ_CP082290 | ||
Organism | Klebsiella pneumoniae subsp. pneumoniae strain Kp6 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | R4Y4A3 |
Locus tag | K6T93_RS24810 | Protein ID | WP_002882817.1 |
Coordinates | 5077916..5078299 (-) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | J2DFR0 |
Locus tag | K6T93_RS24815 | Protein ID | WP_004150355.1 |
Coordinates | 5078299..5078541 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K6T93_RS24795 (K6T93_24795) | 5075282..5076184 | + | 903 | WP_002882822.1 | formate dehydrogenase subunit beta | - |
K6T93_RS24800 (K6T93_24800) | 5076181..5076816 | + | 636 | WP_002882818.1 | formate dehydrogenase cytochrome b556 subunit | - |
K6T93_RS24805 (K6T93_24805) | 5076813..5077742 | + | 930 | WP_004150358.1 | formate dehydrogenase accessory protein FdhE | - |
K6T93_RS24810 (K6T93_24810) | 5077916..5078299 | - | 384 | WP_002882817.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
K6T93_RS24815 (K6T93_24815) | 5078299..5078541 | - | 243 | WP_004150355.1 | CopG family transcriptional regulator | Antitoxin |
K6T93_RS24820 (K6T93_24820) | 5078746..5079663 | + | 918 | WP_032422045.1 | alpha/beta hydrolase | - |
K6T93_RS24825 (K6T93_24825) | 5079677..5080618 | - | 942 | WP_004178031.1 | fatty acid biosynthesis protein FabY | - |
K6T93_RS24830 (K6T93_24830) | 5080663..5081100 | - | 438 | WP_002882809.1 | D-aminoacyl-tRNA deacylase | - |
K6T93_RS24835 (K6T93_24835) | 5081097..5081957 | - | 861 | WP_004146232.1 | virulence factor BrkB family protein | - |
K6T93_RS24840 (K6T93_24840) | 5081951..5082550 | - | 600 | WP_004151865.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14377.62 Da Isoelectric Point: 7.3178
>T214526 WP_002882817.1 NZ_CP082290:c5078299-5077916 [Klebsiella pneumoniae subsp. pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
Download Length: 384 bp
>T214526 NZ_CP110128:424775-425062 [Pseudomonas sp. WJP1]
ATGACCGAACAATTCACTCGCTGGGACTCTGCCGAGTACCTCAAGACCGAAGAGGACATGGCAAATTATCTGGACGCTTG
CATGGAGGAAGCGGGAGATGATCCAGCATTCATCGCCAAAGCTCTCGGGACCATTGCACGTGCTCGCGGCATGACCCAGG
TCGCGCGGGATGCGGGGCTGTCTCGGGAAAGTCTCTACCGCGCATTGTCAGGTGAAGGGAATCCGGAGTTCGGGACCATC
CTGAAGGTCGTTAAGGCGTTAGGCTTGAAATTACACGCCAGCACCTGA
ATGACCGAACAATTCACTCGCTGGGACTCTGCCGAGTACCTCAAGACCGAAGAGGACATGGCAAATTATCTGGACGCTTG
CATGGAGGAAGCGGGAGATGATCCAGCATTCATCGCCAAAGCTCTCGGGACCATTGCACGTGCTCGCGGCATGACCCAGG
TCGCGCGGGATGCGGGGCTGTCTCGGGAAAGTCTCTACCGCGCATTGTCAGGTGAAGGGAATCCGGAGTTCGGGACCATC
CTGAAGGTCGTTAAGGCGTTAGGCTTGAAATTACACGCCAGCACCTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9567.83 Da Isoelectric Point: 4.3509
>AT214526 WP_004150355.1 NZ_CP082290:c5078541-5078299 [Klebsiella pneumoniae subsp. pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW
Download Length: 243 bp
>AT214526 NZ_CP110128:424473-424778 [Pseudomonas sp. WJP1]
ATGACGGAGATTCTTCGAAGTTCGACATTCTCCGGCTGGCTATTGAAGCTGGCCGATAGCCGCGCCAGGATGCGTATTCA
GGTGCGAATTGACCGCATGGCCGATGGAAATTTTGGTGATGTCAAAGCCATCGGAGAAGGGTTGAGTGAAGCACGTATCG
ACTATGGTCCCGGTTATCGGGTCTATTTCATGCAGCAAGGCAGCCAGTTGGTCATCCTCCTTTGTGGTGGAGACAAAAGC
AGCCAAACCCGCGACATCAAACAAGCCAGGCTCATTGCGAAATCCTGGCAGGAGCAAAACCCATGA
ATGACGGAGATTCTTCGAAGTTCGACATTCTCCGGCTGGCTATTGAAGCTGGCCGATAGCCGCGCCAGGATGCGTATTCA
GGTGCGAATTGACCGCATGGCCGATGGAAATTTTGGTGATGTCAAAGCCATCGGAGAAGGGTTGAGTGAAGCACGTATCG
ACTATGGTCCCGGTTATCGGGTCTATTTCATGCAGCAAGGCAGCCAGTTGGTCATCCTCCTTTGTGGTGGAGACAAAAGC
AGCCAAACCCGCGACATCAAACAAGCCAGGCTCATTGCGAAATCCTGGCAGGAGCAAAACCCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GPK8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GGU9 |