Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4758896..4760577 | Replicon | chromosome |
| Accession | NZ_CP082290 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain Kp6 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A2L0KL13 |
| Locus tag | K6T93_RS23335 | Protein ID | WP_019704723.1 |
| Coordinates | 4758896..4759813 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A6TH05 |
| Locus tag | K6T93_RS23340 | Protein ID | WP_004177809.1 |
| Coordinates | 4759819..4760577 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6T93_RS23315 (K6T93_23315) | 4754202..4755722 | + | 1521 | WP_004210021.1 | sugar ABC transporter ATP-binding protein | - |
| K6T93_RS23320 (K6T93_23320) | 4755719..4756717 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| K6T93_RS23325 (K6T93_23325) | 4756748..4757689 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| K6T93_RS23330 (K6T93_23330) | 4757764..4758771 | + | 1008 | WP_222902678.1 | carbohydrate kinase family protein | - |
| K6T93_RS23335 (K6T93_23335) | 4758896..4759813 | - | 918 | WP_019704723.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| K6T93_RS23340 (K6T93_23340) | 4759819..4760577 | - | 759 | WP_004177809.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| K6T93_RS23345 (K6T93_23345) | 4760663..4761391 | - | 729 | WP_004177810.1 | response regulator transcription factor | - |
| K6T93_RS23350 (K6T93_23350) | 4761664..4763811 | + | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
| K6T93_RS23355 (K6T93_23355) | 4764041..4764727 | + | 687 | WP_102051140.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34632.07 Da Isoelectric Point: 5.4707
>T214525 WP_019704723.1 NZ_CP082290:c4759813-4758896 [Klebsiella pneumoniae subsp. pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
>T214525 NZ_CP110128:424473-424778 [Pseudomonas sp. WJP1]
ATGACGGAGATTCTTCGAAGTTCGACATTCTCCGGCTGGCTATTGAAGCTGGCCGATAGCCGCGCCAGGATGCGTATTCA
GGTGCGAATTGACCGCATGGCCGATGGAAATTTTGGTGATGTCAAAGCCATCGGAGAAGGGTTGAGTGAAGCACGTATCG
ACTATGGTCCCGGTTATCGGGTCTATTTCATGCAGCAAGGCAGCCAGTTGGTCATCCTCCTTTGTGGTGGAGACAAAAGC
AGCCAAACCCGCGACATCAAACAAGCCAGGCTCATTGCGAAATCCTGGCAGGAGCAAAACCCATGA
ATGACGGAGATTCTTCGAAGTTCGACATTCTCCGGCTGGCTATTGAAGCTGGCCGATAGCCGCGCCAGGATGCGTATTCA
GGTGCGAATTGACCGCATGGCCGATGGAAATTTTGGTGATGTCAAAGCCATCGGAGAAGGGTTGAGTGAAGCACGTATCG
ACTATGGTCCCGGTTATCGGGTCTATTTCATGCAGCAAGGCAGCCAGTTGGTCATCCTCCTTTGTGGTGGAGACAAAAGC
AGCCAAACCCGCGACATCAAACAAGCCAGGCTCATTGCGAAATCCTGGCAGGAGCAAAACCCATGA
Antitoxin
Download Length: 253 a.a. Molecular weight: 28548.92 Da Isoelectric Point: 10.0870
>AT214525 WP_004177809.1 NZ_CP082290:c4760577-4759819 [Klebsiella pneumoniae subsp. pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
>AT214525 NZ_CP110128:424775-425062 [Pseudomonas sp. WJP1]
ATGACCGAACAATTCACTCGCTGGGACTCTGCCGAGTACCTCAAGACCGAAGAGGACATGGCAAATTATCTGGACGCTTG
CATGGAGGAAGCGGGAGATGATCCAGCATTCATCGCCAAAGCTCTCGGGACCATTGCACGTGCTCGCGGCATGACCCAGG
TCGCGCGGGATGCGGGGCTGTCTCGGGAAAGTCTCTACCGCGCATTGTCAGGTGAAGGGAATCCGGAGTTCGGGACCATC
CTGAAGGTCGTTAAGGCGTTAGGCTTGAAATTACACGCCAGCACCTGA
ATGACCGAACAATTCACTCGCTGGGACTCTGCCGAGTACCTCAAGACCGAAGAGGACATGGCAAATTATCTGGACGCTTG
CATGGAGGAAGCGGGAGATGATCCAGCATTCATCGCCAAAGCTCTCGGGACCATTGCACGTGCTCGCGGCATGACCCAGG
TCGCGCGGGATGCGGGGCTGTCTCGGGAAAGTCTCTACCGCGCATTGTCAGGTGAAGGGAATCCGGAGTTCGGGACCATC
CTGAAGGTCGTTAAGGCGTTAGGCTTGAAATTACACGCCAGCACCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2L0KL13 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A6TH05 |