Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 4565315..4565831 | Replicon | chromosome |
| Accession | NZ_CP082290 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain Kp6 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A085DK79 |
| Locus tag | K6T93_RS22345 | Protein ID | WP_009309309.1 |
| Coordinates | 4565315..4565599 (-) | Length | 95 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | R4Y888 |
| Locus tag | K6T93_RS22350 | Protein ID | WP_002886901.1 |
| Coordinates | 4565589..4565831 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6T93_RS22320 (K6T93_22320) | 4560799..4561062 | - | 264 | WP_015368564.1 | PTS sugar transporter subunit IIB | - |
| K6T93_RS22325 (K6T93_22325) | 4561192..4561365 | + | 174 | WP_032412860.1 | hypothetical protein | - |
| K6T93_RS22330 (K6T93_22330) | 4561368..4562111 | + | 744 | WP_002886905.1 | MurR/RpiR family transcriptional regulator | - |
| K6T93_RS22335 (K6T93_22335) | 4562468..4564606 | + | 2139 | WP_004186701.1 | anaerobic ribonucleoside-triphosphate reductase | - |
| K6T93_RS22340 (K6T93_22340) | 4564847..4565311 | + | 465 | WP_004178375.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
| K6T93_RS22345 (K6T93_22345) | 4565315..4565599 | - | 285 | WP_009309309.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K6T93_RS22350 (K6T93_22350) | 4565589..4565831 | - | 243 | WP_002886901.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| K6T93_RS22355 (K6T93_22355) | 4565909..4567819 | - | 1911 | WP_023280782.1 | PRD domain-containing protein | - |
| K6T93_RS22360 (K6T93_22360) | 4567842..4568996 | - | 1155 | WP_023280781.1 | lactonase family protein | - |
| K6T93_RS22365 (K6T93_22365) | 4569063..4569803 | - | 741 | WP_002886899.1 | KDGP aldolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11141.99 Da Isoelectric Point: 10.3787
>T214524 WP_009309309.1 NZ_CP082290:c4565599-4565315 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
Download Length: 285 bp
>T214524 NZ_CP110127:3299619-3300197 [Mycolicibacterium fortuitum]
GTGAAGCGTCTCGATCTCGTCGTCGGGTGCAACGGCGCCGGCAAGTCCACCTTCGTCGAGCTCACCCTCTCTCCACTGCT
CCCTGGCAGCCCGTTCGTCAACGCGGATGAAATCGCCAAACATCGCTGGCCGCAAGACCCCGCGTCCCACTCGTACGAAG
CCGCGCTCGTGGCCGCAGAAACCCGTGCCAAACTCATTCAGCTCGGCGAATCCTTCATCGCCGAGACCGTGTTTTCGCAC
CCCTCCAAACTCGAGCTCATCGACGACGCACGGGCCGCTGGATACACCCTGATCCTGCACTGCCTCCTGATCCCCGAAGA
GCTGGCCGTACAGCGAGTGCGCCACCGCGTTCGAGCCGGCGGGCATCACGTGCCCGAGAAGAAGATTCGGGAACGCTACC
AACGGCTTTGGGACCTCGTCGCAATCGCGGCGATCCGGGTCGACTCGGCAACGTTCTACGACAACAGCGCCGTTTCAGGC
CCGCGGATCGTCGCCCAGATCGTCGGCGGGTTCGTCGTGGGATCGCCTACCTGGCCGACATGGACGCCAACAGCACTGAG
TTCCCGCTGGCCTGGATAA
GTGAAGCGTCTCGATCTCGTCGTCGGGTGCAACGGCGCCGGCAAGTCCACCTTCGTCGAGCTCACCCTCTCTCCACTGCT
CCCTGGCAGCCCGTTCGTCAACGCGGATGAAATCGCCAAACATCGCTGGCCGCAAGACCCCGCGTCCCACTCGTACGAAG
CCGCGCTCGTGGCCGCAGAAACCCGTGCCAAACTCATTCAGCTCGGCGAATCCTTCATCGCCGAGACCGTGTTTTCGCAC
CCCTCCAAACTCGAGCTCATCGACGACGCACGGGCCGCTGGATACACCCTGATCCTGCACTGCCTCCTGATCCCCGAAGA
GCTGGCCGTACAGCGAGTGCGCCACCGCGTTCGAGCCGGCGGGCATCACGTGCCCGAGAAGAAGATTCGGGAACGCTACC
AACGGCTTTGGGACCTCGTCGCAATCGCGGCGATCCGGGTCGACTCGGCAACGTTCTACGACAACAGCGCCGTTTCAGGC
CCGCGGATCGTCGCCCAGATCGTCGGCGGGTTCGTCGTGGGATCGCCTACCTGGCCGACATGGACGCCAACAGCACTGAG
TTCCCGCTGGCCTGGATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9045.55 Da Isoelectric Point: 6.3340
>AT214524 WP_002886901.1 NZ_CP082290:c4565831-4565589 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
Download Length: 243 bp
>AT214524 NZ_CP110127:3299192-3299581 [Mycolicibacterium fortuitum]
ATGACGGAGACCGCAGATCGTGTGACCCGGTTCGCCGCTGACCTCATCGACAGTGCTGCCGCGGAAGGTGCACGTCAGAG
CCGGTCGGCCAAGCAGCAGCTCGACCATTGGGCCCGCGTGGGCCGCGCTGTGTCCAGCCGGCACAGCGCCGCCCGCCGAA
AGGTAGAGGCCGCCCTGGCCGGCGACATTGCGCTCGGCGAATTGACCGCCGAGGAAGGCGCGGTATTCGACGCCGAGATC
GCCGCATCAATCGAGGAAAGCCTGGCCCGCACCGACTACGGCAAGGCACTGGCCGCCCGTGGTATCACCACCGTTGCGCT
GGACGAGGACGGCGAGATCGTGCAGTACCTGCCCGACGGCAGCACCGCGGTGTTGGCGCCGCAGCAGTGA
ATGACGGAGACCGCAGATCGTGTGACCCGGTTCGCCGCTGACCTCATCGACAGTGCTGCCGCGGAAGGTGCACGTCAGAG
CCGGTCGGCCAAGCAGCAGCTCGACCATTGGGCCCGCGTGGGCCGCGCTGTGTCCAGCCGGCACAGCGCCGCCCGCCGAA
AGGTAGAGGCCGCCCTGGCCGGCGACATTGCGCTCGGCGAATTGACCGCCGAGGAAGGCGCGGTATTCGACGCCGAGATC
GCCGCATCAATCGAGGAAAGCCTGGCCCGCACCGACTACGGCAAGGCACTGGCCGCCCGTGGTATCACCACCGTTGCGCT
GGACGAGGACGGCGAGATCGTGCAGTACCTGCCCGACGGCAGCACCGCGGTGTTGGCGCCGCAGCAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A085DK79 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GLP0 |