Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3694115..3694772 Replicon chromosome
Accession NZ_CP082280
Organism Enterobacter cancerogenus strain HAEC1

Toxin (Protein)


Gene name cptA Uniprot ID A0A5Q2KE30
Locus tag HU826_RS17365 Protein ID WP_058608592.1
Coordinates 3694115..3694525 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag HU826_RS17370 Protein ID WP_006178375.1
Coordinates 3694506..3694772 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU826_RS17345 (HU826_17345) 3690107..3691840 - 1734 WP_102890247.1 single-stranded-DNA-specific exonuclease RecJ -
HU826_RS17350 (HU826_17350) 3691846..3692559 - 714 WP_006178371.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HU826_RS17355 (HU826_17355) 3692588..3693484 - 897 WP_006178372.1 site-specific tyrosine recombinase XerD -
HU826_RS17360 (HU826_17360) 3693586..3694107 + 522 WP_006178373.1 flavodoxin FldB -
HU826_RS17365 (HU826_17365) 3694115..3694525 - 411 WP_058608592.1 protein YgfX Toxin
HU826_RS17370 (HU826_17370) 3694506..3694772 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
HU826_RS17375 (HU826_17375) 3695067..3696047 + 981 WP_058608593.1 tRNA-modifying protein YgfZ -
HU826_RS17380 (HU826_17380) 3696146..3696805 - 660 WP_006178378.1 hemolysin III family protein -
HU826_RS17385 (HU826_17385) 3697072..3697803 + 732 WP_101738561.1 MurR/RpiR family transcriptional regulator -
HU826_RS17390 (HU826_17390) 3697919..3699352 + 1434 WP_102890244.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16190.97 Da        Isoelectric Point: 11.1724

>T214505 WP_058608592.1 NZ_CP082280:c3694525-3694115 [Enterobacter cancerogenus]
VVLWQSELRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDIIGTPWMLNSGMMLRLRSVDGERRQHLWLAADSMDAAEWRDLRRTMLQQPTQD

Download         Length: 411 bp

>T214505 NZ_CP110117:3891469-3891747 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT214505 WP_006178375.1 NZ_CP082280:c3694772-3694506 [Enterobacter cancerogenus]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT214505 NZ_CP110117:3891206-3891466 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q2KE30

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References