Detailed information of TA system TA214485

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 467719..468372
• Replicon: chromosome
• Accession: NZ_CP082274
• Organism: Acinetobacter sp. AS23

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: K6I41_RS02285
• Protein ID: WP_250375129.1
• Coordinates: 467983..468372 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N9QPI6
• Locus tag: K6I41_RS02280
• Protein ID: WP_005301304.1
• Coordinates: 467719..467976 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6I41_RS02260 (K6I41_02255)	463230..464237	+	1008	WP_003653641.1	DNA-directed RNA polymerase subunit alpha	-
K6I41_RS02265 (K6I41_02260)	464256..464633	+	378	WP_002049717.1	50S ribosomal protein L17	-
K6I41_RS02270 (K6I41_02265)	464815..466305	+	1491	WP_250375127.1	NAD(P)/FAD-dependent oxidoreductase	-
K6I41_RS02275 (K6I41_02270)	466357..467529	-	1173	WP_250375128.1	acyl-CoA dehydrogenase family protein	-
K6I41_RS02280 (K6I41_02275)	467719..467976	+	258	WP_005301304.1	succinate dehydrogenase assembly factor 2	Antitoxin
K6I41_RS02285	467983..468372	+	390	WP_250375129.1	hypothetical protein	Toxin
K6I41_RS02290 (K6I41_02280)	469141..470229	+	1089	WP_013196784.1	hypothetical protein	-
K6I41_RS02295 (K6I41_02285)	470313..470888	+	576	WP_004789598.1	rhombosortase	-
K6I41_RS02300 (K6I41_02290)	471067..473262	+	2196	WP_005301316.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15774.27 Da
• Isoelectric Point: 10.3887

>T214485 WP_250375129.1 NZ_CP082274:467983-468372 [Acinetobacter sp. AS23]
MIKELNFELKYSRFSIIFQLFIGLCLAILFYQLLPPMWWLFSLILLSISFLLFLKQSRISQIAYLDQKSWSVVYLPKKVI
HRVEINKIIDYQLFMVVYFERVPVKVVIIWFDQLPLRYWKKLKVLQKLH

Nucleotide

• Length: 390 bp

>T214485 NZ_CP110114:1838413-1838766 [Arthrobacter sp. YA7-1]
GTGTGGAATGTTGACGTTGAGTTGGTGGAGTCGTGGCTGCTCGGGCTCGATCAGGACTCGTACGAGCAGGTGATCGCCGC
GTTGGAGCTTCTTGCTGAGCGTGGTCCCCAGCTTGGCAGGCCCCTGGTCGACACGGTGGTCCGTTCGCGGCATAAGAACA
TGAAGGAACTTCGGCCCGGATCCAGTGGCCGGTCGGAGCTGCGGATCTTGTTTGCCTTTGATCCTGAGCGGCATGCGATT
TTGCTCGTTGCGGGCGACAAAGCAGGCAGCTGGAGCAAGTGGTACAGGACGAACATTCCGATTGCGGATGAGCTGTTCGA
TGATCATCTGAGGATTCTGAAAGGAGGATCGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10282.69 Da
• Isoelectric Point: 4.3805

>AT214485 WP_005301304.1 NZ_CP082274:467719-467976 [Acinetobacter sp. AS23]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLTADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Nucleotide

• Length: 258 bp

>AT214485 NZ_CP110114:1838766-1839071 [Arthrobacter sp. YA7-1]
ATGGCGAAGACTATTGAAGAGATGCTGGCCAAGCGGCCTGTTGACCGGGTTGCTGTGGACGCTCTCAAGAAGCAACTGCT
CGATGAGGTCCGCGCCTACCGGCTTCGGGAACTCCGGGAGGCATCGGACCTGACACAGGTCGAGCTGGCTGCGCGTCTGC
ACGTCAGCCAGAACAGGGTGTCCCGCATCGAGCACGGTGACATCGATCGCGCCCAGGTCGATACGCTGCGGAAATACGTT
GAAGCGGTCGGCGGCCGGCTTCGTGTCGAGGTTGAACTTGGCGACGAACGGATCCAGATCGCCTGA

Structures

Antitoxin

• AlphaFold DB: N9QPI6