Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4180292..4180914 Replicon chromosome
Accession NZ_CP082269
Organism Enterobacter sp. C2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K4042_RS20165 Protein ID WP_222889156.1
Coordinates 4180292..4180663 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K4042_RS20170 Protein ID WP_286184830.1
Coordinates 4180666..4180914 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4042_RS20150 4177788..4178693 + 906 WP_144818885.1 formate dehydrogenase subunit beta -
K4042_RS20155 4178690..4179325 + 636 WP_042394479.1 formate dehydrogenase cytochrome b556 subunit -
K4042_RS20160 4179322..4180251 + 930 WP_144818887.1 formate dehydrogenase accessory protein FdhE -
K4042_RS20165 4180292..4180663 - 372 WP_222889156.1 type II toxin-antitoxin system VapC family toxin Toxin
K4042_RS20170 4180666..4180914 - 249 WP_286184830.1 CopG family transcriptional regulator Antitoxin
K4042_RS20175 4181045..4181986 - 942 WP_186370588.1 fatty acid biosynthesis protein FabY -
K4042_RS20180 4182031..4182468 - 438 WP_222889157.1 D-aminoacyl-tRNA deacylase -
K4042_RS20185 4182465..4183337 - 873 WP_222889158.1 virulence factor BrkB family protein -
K4042_RS20190 4183331..4183930 - 600 WP_222889159.1 glucose-1-phosphatase -
K4042_RS20195 4184051..4184857 - 807 WP_222889160.1 DeoR/GlpR family DNA-binding transcription regulator -
K4042_RS20200 4184892..4185788 - 897 WP_222889161.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14204.66 Da        Isoelectric Point: 9.4193

>T214479 WP_222889156.1 NZ_CP082269:c4180663-4180292 [Enterobacter sp. C2]
MKHPALFDTNILIDLFSGHLQAIQVLDDYPFQRAISLITWMEIMVGAKKYHQEQRTRIALKAFEVIDISRDIAESIVILR
QKYKMKLPDAIILATAQEHRRELLTRNTKDFAGIPGVVTPYQL

Download         Length: 372 bp

>T214479 NZ_CP110102:c5096391-5095912 [Serratia marcescens]
ATGATTGTGCTGGATACCAACGTCGTTTCGGAATTGCTGCGGCCGGCGCCTCACTACAATGTATTGCGCTGGTTAGATGA
GCAGGATACGTATCGGTTCTATTTGAGCGCCATCGTGGTTGCGGAGTTGTATACGGGCATCGCCTGCATGCCTCACGGCA
AGAAACAGCTCGAACTGCAAACTAACCTCGGCGACATGCTGCAGGAAGAGTTTTCAGACAGAATCTTACCCTTTGACGTC
GGCTGTGCGATGCAGCATGCGGAATTAATGGGCGCCAATCGCCGCCGAGGCATTGGCGTCAGCATGCCCGATACCCAAAT
CGCCGCCACCTGCCTGCATTATGGCGCCACCCTGGCCACCCGCAATACCAAAGACTTCCTCCACTGCGGCATCGAGTTAA
TCGATCCGTGGCAGGCGCCGACCGGCCGTCGGTTGCATGAAGATGCGGCGGAATACTACGTGATGAGCAGAAAGTCCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9498.77 Da        Isoelectric Point: 4.1849

>AT214479 WP_286184830.1 NZ_CP082269:c4180914-4180666 [Enterobacter sp. C2]
MSMVTGMDMGRILLDLSDDMIKQLDDLKQQRNLPRAELLREAVEQYLEKQNQAETAIANALGLWQGCDEDGLEYERKLRG
EW

Download         Length: 249 bp

>AT214479 NZ_CP110102:c5096648-5096388 [Serratia marcescens]
ATGGCGACTATCACCGTCAGAAATCTGGACGACGAAATCAAAGAACTGCTGCGTATTTCAGCGGCGAAAAACGGCCACTC
CATGGAAGAGGAAGCGCGCATGATCCTGAAGCAGGCGCTGGTGAAAAAGCCGCCGCGCTATGGGTTAGGAACACGCATGC
ATCAGTACTTCGCCGAATTCGGCGGCGTTGAGTTGGAGATCCCCCCACGTGATGAGGCCCCTCATCGTATCGTCAACTTT
GATGAAGATGATGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References