Detailed information of TA system TA214478

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3525695..3526358
• Replicon: chromosome
• Accession: NZ_CP082269
• Organism: Enterobacter sp. C2

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: K4042_RS17085
• Protein ID: WP_222888789.1
• Coordinates: 3525695..3526111 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A090UVW5
• Locus tag: K4042_RS17090
• Protein ID: WP_042388033.1
• Coordinates: 3526092..3526358 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K4042_RS17065	3521698..3523431	-	1734	WP_222888788.1	single-stranded-DNA-specific exonuclease RecJ	-
K4042_RS17070	3523437..3524147	-	711	WP_042388024.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
K4042_RS17075	3524170..3525066	-	897	WP_042388027.1	site-specific tyrosine recombinase XerD	-
K4042_RS17080	3525167..3525688	+	522	WP_042388029.1	flavodoxin FldB	-
K4042_RS17085	3525695..3526111	-	417	WP_222888789.1	protein YgfX	Toxin
K4042_RS17090	3526092..3526358	-	267	WP_042388033.1	FAD assembly factor SdhE	Antitoxin
K4042_RS17095	3526621..3527604	+	984	WP_222888790.1	tRNA-modifying protein YgfZ	-
K4042_RS17100	3527689..3528348	-	660	WP_144816076.1	hemolysin III family protein	-
K4042_RS17105	3528639..3529367	+	729	WP_144816820.1	MurR/RpiR family transcriptional regulator	-
K4042_RS17110	3529496..3530929	+	1434	WP_222888791.1	6-phospho-beta-glucosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16428.36 Da
• Isoelectric Point: 10.0968

>T214478 WP_222888789.1 NZ_CP082269:c3526111-3525695 [Enterobacter sp. C2]
VVLWQSDLRVSWRAQWLSLLLHGLVAAIILLAPWPLRYTPLWLILLSLVVFDCVRSQRRINACHGEIKLLMDSRLRWQGE
EWDIIGTPWMLTNGMMLRLRKKQGGRVHHLWLESDSMDEREWRDLRRMLLQQPATGEH

Nucleotide

• Length: 417 bp

>T214478 NZ_CP110102:3672685-3672888 [Serratia marcescens]
ATGACTAAAACCGACTATCTGATGCGTTTACGTAAATGCACCACGATTGATACTCTCGAACGTGTTATTGAGAAAAATAA
GTACGAGCTTTCCGATGATGAACTGGAGCTGTTTTACTCAGCGGCAGATCATCGTCTGGCAGAGCTCACCATGAACAAAC
TGTATGACAAAATCCCCACCTCCGTTTGGAAATATGTCAGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10543.95 Da
• Isoelectric Point: 4.8616

>AT214478 WP_042388033.1 NZ_CP082269:c3526358-3526092 [Enterobacter sp. C2]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGEPADTELQRMVQLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT214478 NZ_CP110102:3672267-3672635 [Serratia marcescens]
ATGGATGAGTATTCGCCTAAGCGACACGACATTGCTCAGCTCAAATTCTTGTGCGAAAATTTGTATGATGAAGGTATCGC
TACCCTGGGAGACAGTCATCATGGGTGGGTCAACGATCCGACGTCCTCCGTCAACCTGCAGCTTAATGAGTTGATCGAAC
ATATCGCTTCGTTTGTGATGAGTTATAAAATTAAATACATGGACGAATCTGACCTGTCGGAGTTAGTCGAAGAATATCTC
GACGATACCTATACGCTGTTCAGCAGCTATGGTATCAATGATTCCGACCTGCGCCGCTGGCAAAAAACCAAGGCGAGATT
ATTCAGAATGTTCTCAGGAGAGGACATCTGTACGACAATGAAAACTTAG

Structures

Antitoxin

• AlphaFold DB: A0A090UVW5