Detailed information of TA system TA214465

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2147279..2148207
• Replicon: chromosome
• Accession: NZ_CP082269
• Organism: Enterobacter sp. C2

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: K4042_RS10540
• Protein ID: WP_222887641.1
• Coordinates: 2147731..2148207 (+)
• Length: 159 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: K4042_RS10535
• Protein ID: WP_144815692.1
• Coordinates: 2147279..2147731 (+)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K4042_RS10520	2143940..2144077	+	138	WP_072015219.1	stationary-phase-induced ribosome-associated protein	-
K4042_RS10525	2144282..2145979	+	1698	WP_222887637.1	NAD-dependent malic enzyme	-
K4042_RS10530	2146189..2147199	+	1011	WP_222887639.1	alcohol dehydrogenase AdhP	-
K4042_RS10535	2147279..2147731	+	453	WP_144815692.1	DUF2384 domain-containing protein	Antitoxin
K4042_RS10540	2147731..2148207	+	477	WP_222887641.1	RES family NAD+ phosphorylase	Toxin
K4042_RS10545	2148217..2150292	-	2076	WP_222887642.1	glycogen debranching protein GlgX	-
K4042_RS10550	2150366..2152900	-	2535	WP_222887644.1	malto-oligosyltrehalose synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (6-140)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (97-147)

Sequences

Toxin

Protein

• Length: 159 a.a.
• Molecular weight: 17694.20 Da
• Isoelectric Point: 4.6362

>T214465 WP_222887641.1 NZ_CP082269:2147731-2148207 [Enterobacter sp. C2]
MTTQLFWRLVKTRYLATAFDGYGARTFGGRWNSRGRECVYLGSSKALCVLETLVHLEIEDIAEGYSFLTIEIPTELIATL
DLNTLPEEWQADPAPLSTQQIGDQWLADVNNGLLLRVPSTITGEWNALFNPEHPDAKTALLSVKAEPFIIDPRLGKRC

Nucleotide

• Length: 477 bp

>T214465 NZ_CP110087:1979866-1980126 [Moraxella bovis]
ATTGAGGCCTTATTTGTAGCATTAGGGGCGGACATCTCTGAGCGAGCAGGTTCACGCATGGCTGTGGCGCTAAACGGGCA
AGTCATGGTTTTTCATCGCCCACACCCAAGCCCAAATACTGACAAAAGTGCGGTTATGAGCATTAGAAAATGGCTTGATG
GCATGGGTATCACACCATTAGATGACGACAGCCAAACAGACGAATACGCAGACAAACAAACCGACGAACAGGAGCAGACT
CATGAACACAATGACAATTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 15996.37 Da
• Isoelectric Point: 10.4439

>AT214465 WP_144815692.1 NZ_CP082269:2147279-2147731 [Enterobacter sp. C2]
MTMHVFTPKAAAIPHDLLSTLGLPAAAIAAHDSINVGLSATILRSIADKTQLDEVTLLRMAGIDRNTYSRRLNSAEQRFS
PEQSARVYTLARAISAASELFNNNNVRLAQWLSKPAKGLGGKRPAELLSTPAGAEAVLTLVGRLEHGVLS

Nucleotide

• Length: 453 bp

>AT214465 NZ_CP110087:1980107-1980442 [Moraxella bovis]
ATGAACACAATGACAATTAACAATCATAAAGCCTTAATCACTTTTGACAGTGAGTTAGGACTGTTTCGTGGGGAGTTTAT
CGGATTAAATGGCGGGGCAGATTTTTATGCTGACAGCGTAGATGGTCTCAATGAACAAGGGGCTTTATCCCTGCAAGCCT
TTTTAGATGTATGTCAAGAACAGGGCATTAGCCCTTATCAGTCGTACAGTGGCAAATTTGTCACACGCCTACCCAAAGAG
TTACATCAAAAAATCGCAGAAACTGCTACCGCCAAGGGTATTAGCCTAAACCAGTGGATTAATGAAACACTCAGCCGTGA
AGTTGGCTTTGCCTGA