Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 986956..987576 Replicon chromosome
Accession NZ_CP082269
Organism Enterobacter sp. C2

Toxin (Protein)


Gene name Hha Uniprot ID A0A090V3B8
Locus tag K4042_RS04725 Protein ID WP_042391642.1
Coordinates 986956..987174 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A090V5R8
Locus tag K4042_RS04730 Protein ID WP_042391644.1
Coordinates 987202..987576 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4042_RS04710 983318..984898 - 1581 WP_222890568.1 EAL domain-containing protein -
K4042_RS04715 985611..986105 - 495 WP_222889726.1 YlaC family protein -
K4042_RS04720 986208..986774 - 567 WP_222889727.1 maltose O-acetyltransferase -
K4042_RS04725 986956..987174 - 219 WP_042391642.1 HHA domain-containing protein Toxin
K4042_RS04730 987202..987576 - 375 WP_042391644.1 Hha toxicity modulator TomB Antitoxin
K4042_RS04735 988012..991161 - 3150 WP_222889728.1 multidrug efflux RND transporter permease subunit AcrB -
K4042_RS04740 991184..992389 - 1206 WP_222889729.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T214464 WP_042391642.1 NZ_CP082269:c987174-986956 [Enterobacter sp. C2]
MSDKPLTKVDYLMRLRRCQTIDTLERVIEKNKYELSDNELTVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T214464 NZ_CP110087:c1455601-1455359 [Moraxella bovis]
ATGAATTATAGCGAATTTCGCCAAAACCTAGCCTCTGCCCTTGATTATGTTCAAGACAGCCATGCCCCTGTGATTGTCAA
ACGTGGCAAACATTCTGCGGTGGTGATTAGTCTTGATGAATATAATGCTTTTAAAGAAACAGATTATCTATTGTCAAACC
CTGCTAATGCCGAACACCTTATGCGTGGCGTGCAAGCGGTAAAAAATCGTCAACTTACCCAAAGGGATTTGATTGAGGAT
TAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14452.28 Da        Isoelectric Point: 5.1573

>AT214464 WP_042391644.1 NZ_CP082269:c987576-987202 [Enterobacter sp. C2]
MDEYSPKRHDVAQLKFLCETLYHDCLSNLEESHHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGISTEDLQKWRKSGNRLFRCFVNVSKANPVSLSC

Download         Length: 375 bp

>AT214464 NZ_CP110087:c1455369-1455112 [Moraxella bovis]
TTGAGGATTAGATGGTTTGATGAGGTATGGGAGGATTATTTGTATTGGCAAAGCCAAGATAAGAAAACCATAAAACGTAT
TAATACCTTGATTAAGGATTGCAGACGAGACCCTTTTGACGGTATCGGCAAACCCGAACCATTAAAATATAACCTAACAG
GCTACTGGTTAAGACGCATTAATGATGCCAACCGCTTGGTTTATTGTTGCGAAAGTGAAACACTCATCATTTCATGCCGT
CATCATTATGAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090V3B8

Antitoxin

Source ID Structure
AlphaFold DB A0A090V5R8

References