Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 246405..247196 Replicon chromosome
Accession NZ_CP082269
Organism Enterobacter sp. C2

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag K4042_RS01130 Protein ID WP_222889333.1
Coordinates 246678..247196 (+) Length 173 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag K4042_RS01125 Protein ID WP_144817999.1
Coordinates 246405..246674 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4042_RS01110 242671..243525 + 855 WP_042393216.1 RNA polymerase sigma factor RpoH -
K4042_RS01115 243663..244928 + 1266 WP_222889332.1 4-aminobutyrate--2-oxoglutarate transaminase -
K4042_RS01120 245126..246226 + 1101 WP_144817998.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
K4042_RS01125 246405..246674 + 270 WP_144817999.1 DUF1778 domain-containing protein Antitoxin
K4042_RS01130 246678..247196 + 519 WP_222889333.1 GNAT family N-acetyltransferase Toxin
K4042_RS01135 247200..247586 - 387 WP_144818001.1 aspartate 1-decarboxylase autocleavage activator PanM -
K4042_RS01140 248170..249096 + 927 WP_042393203.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
K4042_RS01145 249093..250370 + 1278 WP_144818003.1 high-affinity branched-chain amino acid ABC transporter permease LivM -
K4042_RS01150 250367..251134 + 768 WP_103820364.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
K4042_RS01155 251152..251865 + 714 WP_042393287.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
K4042_RS01160 251970..252191 + 222 WP_222889334.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19261.25 Da        Isoelectric Point: 8.6497

>T214462 WP_222889333.1 NZ_CP082269:246678-247196 [Enterobacter sp. C2]
VENLTIEILAEDAEYDWQQFDCGETALNLFLIEHLKRQHAGKILRAYILRTTTPERRVLGYYTLSGSCFERVALPSKSQQ
KKIPYKNIPSVTLGRLAVDRSLQGKGWGSVLVSHAMKVVYSASQAVGIHGLFVEAINEKAPAFYLSLGFIPLTGENAHAL
FYPTKCIERLFS

Download         Length: 519 bp

>T214462 NZ_CP110087:c926743-926465 [Moraxella bovis]
ATGATTTTTGAATGGGACGACAACAAAAATCGGACAAACAAGCAAAAGCACGGTGTCAGCTTTGAGAGTGCAAGCCGTAT
TTTTCTTGACCCATTTTTGATTGTTACAGAAGACACAAGTTCTGATGAAGTGCGGTGGCTTGGTGTGGGTAGTGTAGATG
GCGTGGTGATTTTACTCGTTGTACACACCCATACTGATACAGACGGTACAGAAATCATTCGCATTATCTCAGCACGCAAA
CTTAGCAGAGGAGAAATAGAACGCTATGGCTATTGTTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10143.52 Da        Isoelectric Point: 5.7252

>AT214462 WP_144817999.1 NZ_CP082269:246405-246674 [Enterobacter sp. C2]
MTALKKQRIDLRLTDDDKSIIEEAAALTNQSVTQFMLTSAAERAAEVIEQHRRVILNDESWTRVMEALGNPPSPNEKLHR
AAKRLQDME

Download         Length: 270 bp

>AT214462 NZ_CP110087:c926478-926191 [Moraxella bovis]
ATGGCTATTGTTAGAAAAACCTTAGACGATATCAAACACACACCCATTGATAAAGATGAATTGGCACAACTGCAATCAAT
GAGCGATGATAGCATTAACTACGATGATATTCCGCCATTAACTGACGTTCAAATTGCCAATTTGCGTTTGTACAAGCCCA
TTAAGCAACAAATCACATTAAGGCTTGACAGCGACATTGTGGCGTGGCTTAAAAAAGACGGCAAGGGTTATCAAACTCGT
GCTAATCAATTATTAAGACAGTTAATGTTGAAAGAATTAACCACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References