Detailed information of TA system TA214461

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 117148..117759
• Replicon: chromosome
• Accession: NZ_CP082269
• Organism: Enterobacter sp. C2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: K4042_RS00570
• Protein ID: WP_222889261.1
• Coordinates: 117148..117333 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: K4042_RS00575
• Protein ID: WP_222889262.1
• Coordinates: 117349..117759 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K4042_RS00555	112479..114332	+	1854	WP_222889258.1	selenocysteine-specific translation elongation factor	-
K4042_RS00560	114345..115229	-	885	WP_222889259.1	ROK family protein	-
K4042_RS00565	115394..116932	+	1539	WP_222889260.1	aldehyde dehydrogenase AldB	-
K4042_RS00570	117148..117333	+	186	WP_222889261.1	type II toxin-antitoxin system HicA family toxin	Toxin
K4042_RS00575	117349..117759	+	411	WP_222889262.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
K4042_RS00580	117799..119055	-	1257	WP_042393963.1	valine--pyruvate transaminase	-
K4042_RS00585	119180..121216	-	2037	WP_222889263.1	alpha-amylase	-
K4042_RS00590	121531..122436	+	906	WP_144818492.1	protein bax	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7016.37 Da
• Isoelectric Point: 12.2533

>T214461 WP_222889261.1 NZ_CP082269:117148-117333 [Enterobacter sp. C2]
VKSQDVVTILKRHGWMLVRVRGSHHQFCHPMRTGLVTVPHPRKDIKPGTLAQIWRQAGLKL

Nucleotide

• Length: 186 bp

>T214461 NZ_CP110087:762333-762668 [Moraxella bovis]
ATGTGCGAATTAATGTATGAATTAGAATTTGACGAGCGAGCCTTAAAAGAATGGCAAAAACTGGGCGACACCATAAAAAC
GCAGTTTAAAAAGAGACTGGCTAAGGTGCTAAAAAATCCGCACATCATCGCCAATCGCCTAAGCGGTGGACAAAATTTAT
ACAAAATCAACTTCCGCTCGGCAGGTTATCGCCTTGTGTATCAAGTTGAAGATGATAAAGTGGTGGTGTTTGTCATCGTG
ATGGGTAAGCGTGAGAAAAATGCCGTCTATGACACCGCCGAAGAATGGCTTGCTGAACGTCAATCGGACAATCAAGACAC
ACAATCTGTCAAATAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 15116.96 Da
• Isoelectric Point: 4.7549

>AT214461 WP_222889262.1 NZ_CP082269:117349-117759 [Enterobacter sp. C2]
MFYPAYIHADADGSASGFFPDVPGCFFAGDTLDDAFQDAKEALTVHFELICEIGETLPGPGSIEAHLKSHPADFTDGQWL
LVDININQFDGRAERINITLPKRLLTKIDHFVREHPDYSNRSAFLAEAARRVLPGR

Nucleotide

• Length: 411 bp

>AT214461 NZ_CP110087:762091-762333 [Moraxella bovis]
ATGGCAAATATCGTGGCTCGTGTGGACGATGACCTAAAAGCCCAATCATTTTTGGTACTGCAAGAACTTGGCGTGACACC
GTCCGAGCTTATCCGCCAAACCTTGCAATATGTGGCTTATCACAAAAAATTACCCTTTAAGACGGTGGTTTTGACCGATG
AAGACAGTGAGCTTTTAGCCCTTGCCAAAGAACGCCTTGATAATCCTGCCCCACGCATCAAAGTCAGTTTGGACGAGCTT
TAA