Detailed information of TA system TA214460

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 50227..51260
• Replicon: chromosome
• Accession: NZ_CP082269
• Organism: Enterobacter sp. C2

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: K4042_RS00250
• Protein ID: WP_222889225.1
• Coordinates: 50685..51260 (+)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: K4042_RS00245
• Protein ID: WP_222889224.1
• Coordinates: 50227..50685 (+)
• Length: 153 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K4042_RS00220	45566..46834	-	1269	WP_222889219.1	MFS transporter	-
K4042_RS00225	47208..47504	-	297	WP_222889220.1	contact-dependent growth inhibition system immunity protein	-
K4042_RS00230	47734..48501	+	768	Protein_45	class A beta-lactamase	-
K4042_RS00235	48835..49539	+	705	WP_222889222.1	hypothetical protein	-
K4042_RS00240	49532..49966	+	435	WP_222889223.1	hypothetical protein	-
K4042_RS00245	50227..50685	+	459	WP_222889224.1	helix-turn-helix domain-containing protein	Antitoxin
K4042_RS00250	50685..51260	+	576	WP_222889225.1	PIN domain-containing protein	Toxin
K4042_RS00260	51802..53196	+	1395	WP_144818368.1	glycoside-pentoside-hexuronide family transporter	-
K4042_RS00265	53209..55527	+	2319	WP_222889226.1	alpha-xylosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-115)

Antitoxin

• Helix-turn-helix domain, group 17 (83-131)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21874.50 Da
• Isoelectric Point: 6.4918

>T214460 WP_222889225.1 NZ_CP082269:50685-51260 [Enterobacter sp. C2]
MRHSPYPVVLDACVLYPARLRDLLMHLGLVGLYQPKWSRDIHHEWCRNLLKNRSDIQAETLEYTVKLMNQALPDANITGY
EYLIEGLTLPDIDDRHVLAAAIRAKAEVIVTLNKKDFPAVLLAPFNIEALHPDEFISDLFDLNHALALEAVRRQRQSLRH
PPMAVEDFLAMLLKQGLTRTVKVLEGYECIL

Nucleotide

• Length: 576 bp

>T214460 NZ_CP110087:644175-644576 [Moraxella bovis]
ATGTTTAGTTTTATGCTGGATACCAATATCTGCATTTATGTGATAAAAGAACGCCCCATAAAAGCATTAAACAAATTTAA
CCAATATGCAGGGCGGATTTGCGTAAGCAGTATCGTGGCAAGCGAGTTGTATTTTGGGGCATACAACAGCCAATTTATGG
ATAAAAATCTACATCAAGTCGAAGATTTTTTATCACGTTTGACGGTGCTTGATTATACCGCAGAATGCTCGCCCCATTAC
GGCGAGATTTGTGCTGATTTGACCAAGCAGGGCAAGCTCATTAGTGAAAATGACATTCATATCGCCTCTCATGCACGGGC
ATTGGGGCTGACCTTGATTACCAATAATACCGATGAATTTAAACGAGTGTCAGGGCTTAGGATTGGTAATTGGGCGATTT
GA

Antitoxin

Protein

• Length: 153 a.a.
• Molecular weight: 17012.51 Da
• Isoelectric Point: 6.4936

>AT214460 WP_222889224.1 NZ_CP082269:50227-50685 [Enterobacter sp. C2]
MTTTLTNLNLPDPHESELAQRGQRELAAYLSTKLQTQRISIVGEDDKTHIIELPTSAMTMLVEVLGELAAGNAVQIVPVH
AELTTQEAANILNVSRPHMVKLLEKGNLPFHKIGRHRRVLFADLMEYKKRRENESLNAMQALADQAQDTGMY

Nucleotide

• Length: 459 bp

>AT214460 NZ_CP110087:643927-644160 [Moraxella bovis]
ATGCAAACCAGTGTTTTTTTTAATAATCGCACCCAAGCGGTTCGCATTCCTGCCAAATTTCGCTTTGATGACGATGTCAA
AGCCGTCATGATTAGAAAAGTGGGCAATGAGCGGATTTTGACCCCAATTGATGGTGTGTGGGACAGCTTTTTTTTGAGTG
ATGAGCGAGCGAGTGATGATTTTATGGCAAACCGCCCGACCATGCCAAAAAGCGAGCGATTGACTTTTGACTGA