Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1094153..1094646 Replicon chromosome
Accession NZ_CP082267
Organism Enterococcus lactis strain E843

Toxin (Protein)


Gene name relE Uniprot ID A0A6N3ERT3
Locus tag K4199_RS06310 Protein ID WP_070872447.1
Coordinates 1094380..1094646 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A829AAJ0
Locus tag K4199_RS06305 Protein ID WP_002329324.1
Coordinates 1094153..1094383 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K4199_RS06275 (K4199_06270) 1090088..1090798 - 711 WP_002308919.1 hypothetical protein -
K4199_RS14380 1091062..1091379 + 318 Protein_1055 PTS alpha-glucoside transporter subunit IIBC -
K4199_RS06280 (K4199_06275) 1091296..1091778 - 483 WP_146094118.1 DNA cytosine methyltransferase -
K4199_RS06285 (K4199_06280) 1092122..1092541 - 420 WP_252702561.1 toxin -
K4199_RS06290 (K4199_06285) 1092565..1092822 - 258 WP_002313665.1 hypothetical protein -
K4199_RS14385 1092997..1093662 + 666 WP_002292140.1 hypothetical protein -
K4199_RS06305 (K4199_06300) 1094153..1094383 + 231 WP_002329324.1 DUF6290 family protein Antitoxin
K4199_RS06310 (K4199_06305) 1094380..1094646 + 267 WP_070872447.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K4199_RS06315 (K4199_06310) 1094899..1095126 + 228 WP_070872449.1 hypothetical protein -
K4199_RS06320 (K4199_06315) 1095142..1096308 + 1167 WP_070872451.1 radical SAM family heme chaperone HemW -
K4199_RS06325 (K4199_06320) 1096542..1097585 + 1044 WP_104760045.1 heat-inducible transcriptional repressor HrcA -
K4199_RS06330 (K4199_06325) 1097679..1098242 + 564 WP_002292135.1 nucleotide exchange factor GrpE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10574.24 Da        Isoelectric Point: 10.3338

>T214459 WP_070872447.1 NZ_CP082267:1094380-1094646 [Enterococcus lactis]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDNQMVVIAIQV
GHRKNVYD

Download         Length: 267 bp

>T214459 NZ_CP110087:205311-205613 [Moraxella bovis]
ATGACCAAGTCTGATAAATTAAAAGCCAAATTGTATGGCGATGTACGAACTTTTGTATTTAGTGATTTGGTTACTTTATT
ATCGCAATTAGGTTATGAAATGCACGAACGGGCAGGTTCTCGTGTGGTATTTGTTCATTGTGATGATAATAGCGACCGCA
TTCATTTGCATAAACCCCACCCCGAAAATACCATTAAAGGTGGAGCATTAAAAGCGGTCAAAGCCTATTTGTCCGAAAAA
GGCTATTTTGATGAATTTAATGATGATGTGTTAAATCAGGAGCTTAAAAATGATGACCTATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8863.97 Da        Isoelectric Point: 4.1938

>AT214459 WP_002329324.1 NZ_CP082267:1094153-1094383 [Enterococcus lactis]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILHEFGGLE

Download         Length: 231 bp

>AT214459 NZ_CP110087:205600-205935 [Moraxella bovis]
ATGATGACCTATAAAGGCTATGTTGGCGAATTTACGCTTGATAATGATGATGAAATATTTTATGGTAAACTTATTGGCAT
TAATCAGCTTGTTACTTTTGAAGCAGACAATGCCCATGATTTAAAACAAGCCTTTTATGACAGCGTGGACGATTATTTGG
CGTTTTGTGCTGAACAAGGCATAGAGCCTGATAAGCCTTTTAAGGGTTCATTTAATGTGCGTATTGATAGCGAATTGCAC
CGCCGTGCTTATATGGCAAGCCGTGACAGTAGTTTAAATGCGTTTGTAGGACAAGCCATTAGTGAAAAGCTAAATAGAAT
GGCTGTATCAATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N3ERT3

Antitoxin

Source ID Structure
AlphaFold DB A0A829AAJ0

References