Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE(toxin) |
Location | 1094153..1094646 | Replicon | chromosome |
Accession | NZ_CP082267 | ||
Organism | Enterococcus lactis strain E843 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A6N3ERT3 |
Locus tag | K4199_RS06310 | Protein ID | WP_070872447.1 |
Coordinates | 1094380..1094646 (+) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A829AAJ0 |
Locus tag | K4199_RS06305 | Protein ID | WP_002329324.1 |
Coordinates | 1094153..1094383 (+) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K4199_RS06275 (K4199_06270) | 1090088..1090798 | - | 711 | WP_002308919.1 | hypothetical protein | - |
K4199_RS14380 | 1091062..1091379 | + | 318 | Protein_1055 | PTS alpha-glucoside transporter subunit IIBC | - |
K4199_RS06280 (K4199_06275) | 1091296..1091778 | - | 483 | WP_146094118.1 | DNA cytosine methyltransferase | - |
K4199_RS06285 (K4199_06280) | 1092122..1092541 | - | 420 | WP_252702561.1 | toxin | - |
K4199_RS06290 (K4199_06285) | 1092565..1092822 | - | 258 | WP_002313665.1 | hypothetical protein | - |
K4199_RS14385 | 1092997..1093662 | + | 666 | WP_002292140.1 | hypothetical protein | - |
K4199_RS06305 (K4199_06300) | 1094153..1094383 | + | 231 | WP_002329324.1 | DUF6290 family protein | Antitoxin |
K4199_RS06310 (K4199_06305) | 1094380..1094646 | + | 267 | WP_070872447.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
K4199_RS06315 (K4199_06310) | 1094899..1095126 | + | 228 | WP_070872449.1 | hypothetical protein | - |
K4199_RS06320 (K4199_06315) | 1095142..1096308 | + | 1167 | WP_070872451.1 | radical SAM family heme chaperone HemW | - |
K4199_RS06325 (K4199_06320) | 1096542..1097585 | + | 1044 | WP_104760045.1 | heat-inducible transcriptional repressor HrcA | - |
K4199_RS06330 (K4199_06325) | 1097679..1098242 | + | 564 | WP_002292135.1 | nucleotide exchange factor GrpE | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10574.24 Da Isoelectric Point: 10.3338
>T214459 WP_070872447.1 NZ_CP082267:1094380-1094646 [Enterococcus lactis]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDNQMVVIAIQV
GHRKNVYD
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGLTANRSGQWRYRIGKYRVLVEIEDNQMVVIAIQV
GHRKNVYD
Download Length: 267 bp
>T214459 NZ_CP110087:205311-205613 [Moraxella bovis]
ATGACCAAGTCTGATAAATTAAAAGCCAAATTGTATGGCGATGTACGAACTTTTGTATTTAGTGATTTGGTTACTTTATT
ATCGCAATTAGGTTATGAAATGCACGAACGGGCAGGTTCTCGTGTGGTATTTGTTCATTGTGATGATAATAGCGACCGCA
TTCATTTGCATAAACCCCACCCCGAAAATACCATTAAAGGTGGAGCATTAAAAGCGGTCAAAGCCTATTTGTCCGAAAAA
GGCTATTTTGATGAATTTAATGATGATGTGTTAAATCAGGAGCTTAAAAATGATGACCTATAA
ATGACCAAGTCTGATAAATTAAAAGCCAAATTGTATGGCGATGTACGAACTTTTGTATTTAGTGATTTGGTTACTTTATT
ATCGCAATTAGGTTATGAAATGCACGAACGGGCAGGTTCTCGTGTGGTATTTGTTCATTGTGATGATAATAGCGACCGCA
TTCATTTGCATAAACCCCACCCCGAAAATACCATTAAAGGTGGAGCATTAAAAGCGGTCAAAGCCTATTTGTCCGAAAAA
GGCTATTTTGATGAATTTAATGATGATGTGTTAAATCAGGAGCTTAAAAATGATGACCTATAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8863.97 Da Isoelectric Point: 4.1938
>AT214459 WP_002329324.1 NZ_CP082267:1094153-1094383 [Enterococcus lactis]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILHEFGGLE
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILHEFGGLE
Download Length: 231 bp
>AT214459 NZ_CP110087:205600-205935 [Moraxella bovis]
ATGATGACCTATAAAGGCTATGTTGGCGAATTTACGCTTGATAATGATGATGAAATATTTTATGGTAAACTTATTGGCAT
TAATCAGCTTGTTACTTTTGAAGCAGACAATGCCCATGATTTAAAACAAGCCTTTTATGACAGCGTGGACGATTATTTGG
CGTTTTGTGCTGAACAAGGCATAGAGCCTGATAAGCCTTTTAAGGGTTCATTTAATGTGCGTATTGATAGCGAATTGCAC
CGCCGTGCTTATATGGCAAGCCGTGACAGTAGTTTAAATGCGTTTGTAGGACAAGCCATTAGTGAAAAGCTAAATAGAAT
GGCTGTATCAATATAA
ATGATGACCTATAAAGGCTATGTTGGCGAATTTACGCTTGATAATGATGATGAAATATTTTATGGTAAACTTATTGGCAT
TAATCAGCTTGTTACTTTTGAAGCAGACAATGCCCATGATTTAAAACAAGCCTTTTATGACAGCGTGGACGATTATTTGG
CGTTTTGTGCTGAACAAGGCATAGAGCCTGATAAGCCTTTTAAGGGTTCATTTAATGTGCGTATTGATAGCGAATTGCAC
CGCCGTGCTTATATGGCAAGCCGTGACAGTAGTTTAAATGCGTTTGTAGGACAAGCCATTAGTGAAAAGCTAAATAGAAT
GGCTGTATCAATATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6N3ERT3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829AAJ0 |