Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1524390..1525064 Replicon chromosome
Accession NZ_CP082238
Organism Acidithiobacillus ferrooxidans strain BYM

Toxin (Protein)


Gene name vapC Uniprot ID B7JBN6
Locus tag K7B00_RS07925 Protein ID WP_009564531.1
Coordinates 1524645..1525064 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B7JBN5
Locus tag K7B00_RS07920 Protein ID WP_012536752.1
Coordinates 1524390..1524644 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7B00_RS07905 (K7B00_07905) 1520065..1521027 - 963 WP_012607230.1 glycosyltransferase family 2 protein -
K7B00_RS07910 (K7B00_07910) 1521208..1522668 + 1461 WP_012536750.1 IMP dehydrogenase -
K7B00_RS07915 (K7B00_07915) 1522672..1524216 + 1545 WP_012536751.1 glutamine-hydrolyzing GMP synthase -
K7B00_RS07920 (K7B00_07920) 1524390..1524644 + 255 WP_012536752.1 plasmid stabilization protein Antitoxin
K7B00_RS07925 (K7B00_07925) 1524645..1525064 + 420 WP_009564531.1 type II toxin-antitoxin system VapC family toxin Toxin
K7B00_RS07930 (K7B00_07930) 1525061..1525294 + 234 WP_226833825.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
K7B00_RS07935 (K7B00_07935) 1525294..1525449 + 156 WP_012536753.1 hypothetical protein -
K7B00_RS07940 (K7B00_07940) 1526129..1527748 + 1620 WP_012536754.1 APC family permease -
K7B00_RS07945 (K7B00_07945) 1527839..1529038 + 1200 WP_012536755.1 glutamate 5-kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14968.11 Da        Isoelectric Point: 4.7051

>T214445 WP_009564531.1 NZ_CP082238:1524645-1525064 [Acidithiobacillus ferrooxidans]
MIVLDTNVVSEAMKPEPDAAVRAWLNEQAAETLYLSSVTLAELLFGIRALPAGKCKNMLDRALTELLELFKDRVLPFDTD
AARHYADLAVTAKNGGRGFPTPDGYIAAVAASRGFIVASRDTSPYEAAGVTVINPWKDA

Download         Length: 420 bp

>T214445 NZ_CP110074:2789482-2789625 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9225.67 Da        Isoelectric Point: 10.7239

>AT214445 WP_012536752.1 NZ_CP082238:1524390-1524644 [Acidithiobacillus ferrooxidans]
MAILTVRNVPDDVHRALRVRAARHGRSTEAEVREILAAAVKPSSRVCMGEALAAIGRKIGLTNEDFAVFESVRDKTPAKP
LRFD

Download         Length: 255 bp

>AT214445 NZ_CP110074:c2789385-2789184 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B7JBN6

Antitoxin

Source ID Structure
AlphaFold DB B7JBN5

References