Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09812-MazE
Location 1355052..1355671 Replicon chromosome
Accession NZ_CP082238
Organism Acidithiobacillus ferrooxidans strain BYM

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag K7B00_RS07015 Protein ID WP_054608979.1
Coordinates 1355052..1355405 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2W1K4M0
Locus tag K7B00_RS07020 Protein ID WP_054608978.1
Coordinates 1355402..1355671 (-) Length 90 a.a.

Genomic Context

K7B00_RS07025K7B00_RS07035K7B00_RS07040K7B00_RS06990K7B00_RS06995K7B00_RS07000K7B00_RS07005K7B00_RS07010K7B00_RS07015K7B00_RS07020
Location: 1355820..1356071 (252 bp)
Type: Others
Protein ID: WP_054608977.1
Location: 1356529..1357665 (1137 bp)
Type: Others
Protein ID: WP_012536490.1
Location: 1357744..1359501 (1758 bp)
Type: Others
Protein ID: WP_012536491.1
Location: 1351589..1351996 (408 bp)
Type: Others
Protein ID: WP_054608983.1
Location: 1351993..1352421 (429 bp)
Type: Others
Protein ID: WP_146235806.1
Location: 1352463..1353872 (1410 bp)
Type: Others
Protein ID: WP_055448960.1
Location: 1354142..1354549 (408 bp)
Type: Others
Protein ID: WP_054608981.1
Location: 1354549..1354839 (291 bp)
Type: Others
Protein ID: WP_054608980.1
Location: 1355052..1355405 (354 bp)
Type: Toxin
Protein ID: WP_054608979.1
Location: 1355402..1355671 (270 bp)
Type: Antitoxin
Protein ID: WP_054608978.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K7B00_RS06990 (K7B00_06990)1351589..1351996-408WP_054608983.1hypothetical protein-
K7B00_RS06995 (K7B00_06995)1351993..1352421-429WP_146235806.1hypothetical protein-
K7B00_RS07000 (K7B00_07000)1352463..1353872-1410WP_055448960.1hypothetical protein-
K7B00_RS07005 (K7B00_07005)1354142..1354549-408WP_054608981.1transcriptional regulator-
K7B00_RS07010 (K7B00_07010)1354549..1354839-291WP_054608980.1type II toxin-antitoxin system HigB family toxin-
K7B00_RS07015 (K7B00_07015)1355052..1355405-354WP_054608979.1type II toxin-antitoxin system PemK/MazF family toxinToxin
K7B00_RS07020 (K7B00_07020)1355402..1355671-270WP_054608978.1hypothetical proteinAntitoxin
K7B00_RS07025 (K7B00_07025)1355820..1356071+252WP_054608977.1type II toxin-antitoxin system prevent-host-death family antitoxin-
K7B00_RS07035 (K7B00_07035)1356529..1357665+1137WP_012536490.1FIST N-terminal domain-containing protein-
K7B00_RS07040 (K7B00_07040)1357744..1359501+1758WP_012536491.1thiol reductant ABC exporter subunit CydD-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 12842.63 Da        Isoelectric Point: 7.8845

>T214442 WP_054608979.1 NZ_CP082238:c1355405-1355052 [Acidithiobacillus ferrooxidans]
MIGRKIPSPGDVYWINPNPTAGNEIRDRHRFVVITPTEINKLGLVTCVPITSGGNYARQNGLTVVIAGHDTTGVAVCNQM
RTFDLHARAGDVKYVETLDQQTTREIINRVTSIIDPA

Download         Length: 354 bp

>T214442 NZ_CP110074:2788843-2788992 [Enterococcus faecalis]
ATGCGTATGCACGTATTTCCGAAATTTAGAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGG
GTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9708.11 Da        Isoelectric Point: 5.1053

>AT214442 WP_054608978.1 NZ_CP082238:c1355671-1355402 [Acidithiobacillus ferrooxidans]
MLVTRIRKQGGAAVVTLPAEVLRQLDAGIGEDLSIEVSQHTVIMRPARGERRRYNLEELLAGVTGQDMQILAGDTAWARE
GDPAGRELI

Download         Length: 270 bp

>AT214442 NZ_CP110074:c2789109-2788925 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2W1K4M0

References