Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09812-MazE
Location 1355052..1355671 Replicon chromosome
Accession NZ_CP082238
Organism Acidithiobacillus ferrooxidans strain BYM

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag K7B00_RS07015 Protein ID WP_054608979.1
Coordinates 1355052..1355405 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2W1K4M0
Locus tag K7B00_RS07020 Protein ID WP_054608978.1
Coordinates 1355402..1355671 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7B00_RS06990 (K7B00_06990) 1351589..1351996 - 408 WP_054608983.1 hypothetical protein -
K7B00_RS06995 (K7B00_06995) 1351993..1352421 - 429 WP_146235806.1 hypothetical protein -
K7B00_RS07000 (K7B00_07000) 1352463..1353872 - 1410 WP_055448960.1 hypothetical protein -
K7B00_RS07005 (K7B00_07005) 1354142..1354549 - 408 WP_054608981.1 transcriptional regulator -
K7B00_RS07010 (K7B00_07010) 1354549..1354839 - 291 WP_054608980.1 type II toxin-antitoxin system HigB family toxin -
K7B00_RS07015 (K7B00_07015) 1355052..1355405 - 354 WP_054608979.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
K7B00_RS07020 (K7B00_07020) 1355402..1355671 - 270 WP_054608978.1 hypothetical protein Antitoxin
K7B00_RS07025 (K7B00_07025) 1355820..1356071 + 252 WP_054608977.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
K7B00_RS07035 (K7B00_07035) 1356529..1357665 + 1137 WP_012536490.1 FIST N-terminal domain-containing protein -
K7B00_RS07040 (K7B00_07040) 1357744..1359501 + 1758 WP_012536491.1 thiol reductant ABC exporter subunit CydD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 12842.63 Da        Isoelectric Point: 7.8845

>T214442 WP_054608979.1 NZ_CP082238:c1355405-1355052 [Acidithiobacillus ferrooxidans]
MIGRKIPSPGDVYWINPNPTAGNEIRDRHRFVVITPTEINKLGLVTCVPITSGGNYARQNGLTVVIAGHDTTGVAVCNQM
RTFDLHARAGDVKYVETLDQQTTREIINRVTSIIDPA

Download         Length: 354 bp

>T214442 NZ_CP110074:2788843-2788992 [Enterococcus faecalis]
ATGCGTATGCACGTATTTCCGAAATTTAGAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGG
GTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9708.11 Da        Isoelectric Point: 5.1053

>AT214442 WP_054608978.1 NZ_CP082238:c1355671-1355402 [Acidithiobacillus ferrooxidans]
MLVTRIRKQGGAAVVTLPAEVLRQLDAGIGEDLSIEVSQHTVIMRPARGERRRYNLEELLAGVTGQDMQILAGDTAWARE
GDPAGRELI

Download         Length: 270 bp

>AT214442 NZ_CP110074:c2789109-2788925 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2W1K4M0

References