Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 1140997..1141522 Replicon chromosome
Accession NZ_CP082238
Organism Acidithiobacillus ferrooxidans strain BYM

Toxin (Protein)


Gene name stbE Uniprot ID B7J6U7
Locus tag K7B00_RS05935 Protein ID WP_009564272.1
Coordinates 1141241..1141522 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B7J6U6
Locus tag K7B00_RS05930 Protein ID WP_009564270.1
Coordinates 1140997..1141251 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7B00_RS05890 (K7B00_05890) 1136044..1136538 - 495 WP_257246173.1 LysR substrate-binding domain-containing protein -
K7B00_RS16705 1136521..1136715 - 195 Protein_1158 LysR family transcriptional regulator -
K7B00_RS16710 1136871..1137065 - 195 WP_225487690.1 hypothetical protein -
K7B00_RS05895 (K7B00_05895) 1137058..1137357 + 300 WP_226834093.1 SDR family oxidoreductase -
K7B00_RS05900 (K7B00_05900) 1137526..1138194 + 669 WP_009561118.1 cupin domain-containing protein -
K7B00_RS05905 (K7B00_05905) 1138191..1139354 + 1164 WP_012536412.1 FAD-dependent oxidoreductase -
K7B00_RS05910 (K7B00_05910) 1139351..1139470 + 120 WP_009564254.1 short-chain dehydrogenase -
K7B00_RS05915 (K7B00_05915) 1139463..1139753 + 291 WP_041645337.1 hypothetical protein -
K7B00_RS05920 (K7B00_05920) 1139928..1140263 + 336 WP_012536413.1 shufflon-specific DNA recombinase -
K7B00_RS05925 (K7B00_05925) 1140456..1140749 + 294 WP_012606678.1 YbjQ family protein -
K7B00_RS05930 (K7B00_05930) 1140997..1141251 + 255 WP_009564270.1 antitoxin Antitoxin
K7B00_RS05935 (K7B00_05935) 1141241..1141522 + 282 WP_009564272.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K7B00_RS05945 (K7B00_05945) 1142065..1143288 - 1224 WP_012536416.1 class I SAM-dependent rRNA methyltransferase -
K7B00_RS05950 (K7B00_05950) 1143443..1144495 + 1053 WP_012536417.1 S-methyl-5-thioribose-1-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10757.61 Da        Isoelectric Point: 10.6855

>T214440 WP_009564272.1 NZ_CP082238:1141241-1141522 [Acidithiobacillus ferrooxidans]
MPYELTFHPSALKEWQALDHSVRAPFKKKLAERLVHPRVPSAQLHGHPDRYKIKLRSIGYRLIYQVMETEVQVLVLAVGK
REGSVAYHKAKGR

Download         Length: 282 bp

>T214440 NZ_CP110074:c2716246-2716103 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAGACAATTCAGACGATCCTAGGTTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8832.16 Da        Isoelectric Point: 4.6615

>AT214440 WP_009564270.1 NZ_CP082238:1140997-1141251 [Acidithiobacillus ferrooxidans]
MTHVILADVAASVSELKKNPMGTVAAGEGATVAILNRNEPAFYCVPAATYAALLEHLENLELNALAESRLKDGQTPIKVS
LDAL

Download         Length: 255 bp

>AT214440 NZ_CP110074:2715984-2716170 [Enterococcus faecalis]
TGTGCTAGAATGTAGATGAAAAGAGAGATATGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGATGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B7J6U7

Antitoxin

Source ID Structure
AlphaFold DB B7J6U6

References