Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 501377..502017 Replicon chromosome
Accession NZ_CP082238
Organism Acidithiobacillus ferrooxidans strain BYM

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K7B00_RS02700 Protein ID WP_009567232.1
Coordinates 501607..502017 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID B7J4M0
Locus tag K7B00_RS02695 Protein ID WP_009567231.1
Coordinates 501377..501607 (+) Length 77 a.a.

Genomic Context

K7B00_RS02680K7B00_RS02685K7B00_RS02690K7B00_RS02695K7B00_RS02700K7B00_RS02705K7B00_RS02710K7B00_RS02715K7B00_RS02720
Location: 497255..498385 (1131 bp)
Type: Others
Protein ID: WP_012536159.1
Location: 498385..499350 (966 bp)
Type: Others
Protein ID: WP_009567244.1
Location: 499351..501168 (1818 bp)
Type: Others
Protein ID: WP_012536160.1
Location: 501377..501607 (231 bp)
Type: Antitoxin
Protein ID: WP_009567231.1
Location: 501607..502017 (411 bp)
Type: Toxin
Protein ID: WP_009567232.1
Location: 502150..503248 (1099 bp)
Type: Others
Protein ID: WP_012606567.1
Location: 503288..504775 (1488 bp)
Type: Others
Protein ID: WP_229129796.1
Location: 504772..506016 (1245 bp)
Type: Others
Protein ID: WP_012536161.1
Location: 506009..506704 (696 bp)
Type: Others
Protein ID: WP_009566877.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K7B00_RS02680 (K7B00_02680)497255..498385+1131WP_012536159.1threonine synthase-
K7B00_RS02685 (K7B00_02685)498385..499350+966WP_009567244.1hypothetical protein-
K7B00_RS02690 (K7B00_02690)499351..501168+1818WP_012536160.1DHHA1 domain-containing protein-
K7B00_RS02695 (K7B00_02695)501377..501607+231WP_009567231.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
K7B00_RS02700 (K7B00_02700)501607..502017+411WP_009567232.1type II toxin-antitoxin system VapC family toxinToxin
K7B00_RS02705 (K7B00_02705)502150..503248+1099WP_012606567.1peptide chain release factor 2-
K7B00_RS02710 (K7B00_02710)503288..504775+1488WP_229129796.1lysine--tRNA ligase-
K7B00_RS02715 (K7B00_02715)504772..506016+1245WP_012536161.1lipoprotein-releasing ABC transporter permease subunit-
K7B00_RS02720 (K7B00_02720)506009..506704+696WP_009566877.1ABC transporter ATP-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-127)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15278.46 Da        Isoelectric Point: 7.3848

>T214439 WP_009567232.1 NZ_CP082238:501607-502017 [Acidithiobacillus ferrooxidans]
MTLRYLLDTNICIYIAKHHPPAVRERFVQHGADDLAMSVITLGELCWGAEKSQARDKALASIQRLQERIQVAPLTPQVGI
HYGQIRAALESGGRPIGNNDLWIAAHARAEGWIVVTNNEREFRRVEGLQVENWVTA

Download         Length: 411 bp

>T214439 NZ_CP110074:c2645134-2645033 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8704.76 Da        Isoelectric Point: 4.4217

>AT214439 WP_009567231.1 NZ_CP082238:501377-501607 [Acidithiobacillus ferrooxidans]
MAIARIFQSGNSQAVRLPKEFRFEVDQVEIFRRGNEIILREHPVDGTGVFDALADLPEDFMSDGRQDIPPQARENF

Download         Length: 231 bp

>AT214439 NZ_CP110074:2644909-2645088 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBB7J4M0

References