Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 174604..175223 Replicon chromosome
Accession NZ_CP082238
Organism Acidithiobacillus ferrooxidans strain BYM

Toxin (Protein)


Gene name PumA Uniprot ID A0A2W1KCH5
Locus tag K7B00_RS00850 Protein ID WP_031575563.1
Coordinates 174927..175223 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K7B00_RS00845 Protein ID WP_031575560.1
Coordinates 174604..174921 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7B00_RS16605 170134..171279 + 1146 WP_229129756.1 hypothetical protein -
K7B00_RS00825 (K7B00_00825) 171361..172101 + 741 WP_054608922.1 P-type conjugative transfer protein TrbJ -
K7B00_RS00830 (K7B00_00830) 172113..172367 + 255 WP_012535920.1 EexN family lipoprotein -
K7B00_RS00835 (K7B00_00835) 172381..174075 + 1695 WP_054608923.1 P-type conjugative transfer protein TrbL -
K7B00_RS00840 (K7B00_00840) 174146..174550 + 405 WP_031575557.1 hypothetical protein -
K7B00_RS00845 (K7B00_00845) 174604..174921 - 318 WP_031575560.1 putative addiction module antidote protein Antitoxin
K7B00_RS00850 (K7B00_00850) 174927..175223 - 297 WP_031575563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K7B00_RS00855 (K7B00_00855) 175444..175848 + 405 WP_031575566.1 hypothetical protein -
K7B00_RS00860 (K7B00_00860) 175841..176761 - 921 WP_146235851.1 hypothetical protein -
K7B00_RS00865 (K7B00_00865) 176911..177579 + 669 WP_054608924.1 type IV secretion system protein -
K7B00_RS00870 (K7B00_00870) 177592..178692 + 1101 WP_054608925.1 TrbG/VirB9 family P-type conjugative transfer protein -
K7B00_RS00875 (K7B00_00875) 178694..179698 + 1005 WP_054608926.1 TrbG/VirB9 family P-type conjugative transfer protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(4-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11112.88 Da        Isoelectric Point: 9.6531

>T214438 WP_031575563.1 NZ_CP082238:c175223-174927 [Acidithiobacillus ferrooxidans]
MLELIETNVFREWLEGLRDHQARARIQVRMRRLSLGNPGDVKPVGEGISEMRIDYGPGYRVYFMRRGPVVVALLCGGDKG
SQERDIALAKAIAAQWKE

Download         Length: 297 bp

>T214438 NZ_CP110074:c2644701-2644600 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACAATAAAAAATAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11253.69 Da        Isoelectric Point: 6.2117

>AT214438 WP_031575560.1 NZ_CP082238:c174921-174604 [Acidithiobacillus ferrooxidans]
MEVQFRRYDTVNYLKTEDDIAHYLDAAMEDGDPALILAALGDVARARNLSQLARDAGMSRQGLDKALSGTGNPSLVTVLK
ITQALGLRLSFQPAHTSSHPSATGV

Download         Length: 318 bp

>AT214438 NZ_CP110074:2644481-2644655 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAA
TCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W1KCH5

Antitoxin

Source ID Structure

References