Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 312410..313020 Replicon chromosome
Accession NZ_CP082237
Organism Caldalkalibacillus thermarum TA2.A1

Toxin (Protein)


Gene name mazF Uniprot ID F5LA55
Locus tag HUR95_RS01635 Protein ID WP_007506122.1
Coordinates 312691..313020 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HUR95_RS01630 Protein ID WP_222822871.1
Coordinates 312410..312691 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HUR95_RS01605 (HUR95_01605) 307633..308559 - 927 WP_007506114.1 flagellar hook-basal body protein -
HUR95_RS01610 (HUR95_01610) 308595..309596 - 1002 WP_007506117.1 rod shape-determining protein -
HUR95_RS01615 (HUR95_01615) 309743..310066 - 324 WP_007506118.1 sporulation transcriptional regulator SpoIIID -
HUR95_RS01620 (HUR95_01620) 310276..311121 - 846 WP_007506119.1 M23 family metallopeptidase -
HUR95_RS01625 (HUR95_01625) 311218..312228 - 1011 WP_007506120.1 stage II sporulation protein D -
HUR95_RS01630 (HUR95_01630) 312410..312691 + 282 WP_222822871.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HUR95_RS01635 (HUR95_01635) 312691..313020 + 330 WP_007506122.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HUR95_RS01640 (HUR95_01640) 313080..314408 - 1329 WP_007506123.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
HUR95_RS01645 (HUR95_01645) 314472..315278 - 807 WP_007506124.1 YwmB family TATA-box binding protein -
HUR95_RS01650 (HUR95_01650) 315442..315684 - 243 WP_007506125.1 DUF1146 family protein -
HUR95_RS01655 (HUR95_01655) 315739..317292 - 1554 WP_007506126.1 NADH-quinone oxidoreductase subunit NuoN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

SpoVT-AbrB domain

(21-65)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12284.15 Da        Isoelectric Point: 7.2439

>T214435 WP_007506122.1 NZ_CP082237:312691-313020 [Caldalkalibacillus thermarum TA2.A1]
MHIPERGDLVYLNFNPQAGHEQAGRRPGIVLSPKKFNQVTGFAVVCPITRQQKGYPFEVALPDNLAIQGVILTDQVKSLD
WRARQFEIKGRAPEEIVSECLELIHTFLS

Download         Length: 330 bp

>T214435 NZ_CP110074:c312495-312400 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAGTTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10353.86 Da        Isoelectric Point: 5.2099

>AT214435 WP_222822871.1 NZ_CP082237:312410-312691 [Caldalkalibacillus thermarum TA2.A1]
MKSEEGTKQEKGEVVMTTKVQKWGNSLAVRIPSQIAEQLQIRQGSEMEIVVANGAITFRPKKEKPALDELLAKVTPENRH
NEIDLGVEGNELI

Download         Length: 282 bp

>AT214435 NZ_CP110074:312301-312365 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGCGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F5LA55

Antitoxin

Source ID Structure

References