Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1771616..1773243 Replicon chromosome
Accession NZ_CP082236
Organism Pseudomonas sp. SC3(2021)

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K5Y35_RS07760 Protein ID WP_128613605.1
Coordinates 1771616..1772968 (+) Length 451 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K5Y35_RS07765 Protein ID WP_128613606.1
Coordinates 1772965..1773243 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K5Y35_RS07755 1768429..1771386 - 2958 WP_222834019.1 autotransporter outer membrane beta-barrel domain-containing protein -
K5Y35_RS07760 1771616..1772968 + 1353 WP_128613605.1 HipA domain-containing protein Toxin
K5Y35_RS07765 1772965..1773243 + 279 WP_128613606.1 helix-turn-helix transcriptional regulator Antitoxin
K5Y35_RS07770 1773276..1774112 - 837 WP_222834020.1 amino acid ABC transporter permease -
K5Y35_RS07775 1774109..1774930 - 822 WP_222834021.1 ABC transporter substrate-binding protein -
K5Y35_RS07780 1775044..1775943 + 900 WP_128613608.1 homocysteine S-methyltransferase family protein -
K5Y35_RS07785 1776032..1776703 - 672 WP_222834022.1 GNAT family protein -
K5Y35_RS07790 1776716..1777162 - 447 WP_123469978.1 GNAT family N-acetyltransferase -
K5Y35_RS07795 1777173..1777796 - 624 WP_222834023.1 FMN-binding negative transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-367)

Antitoxin

Cro/C1-type helix-turn-helix domain

(27-80)


Sequences

Toxin        


Download         Length: 451 a.a.        Molecular weight: 50273.17 Da        Isoelectric Point: 6.0808

>T214431 WP_128613605.1 NZ_CP082236:1771616-1772968 [Pseudomonas sp. SC3(2021)]
MYNLTLQIFTAGKWQDAMILSFDDPEKGFESRCSFGYETAYLAENIEAMGSPFSRAVSALYPLDWDGHRSKTPAFVHDIA
PAGAAKRFLLERLGREKPANISADLYLLGRSTPAPIGNMRIKESAEAVDERKPIGFKREDVVHRDNRFLEYAYELGAAIG
GATGAGGEAPKLLLAENKAGLLYPDAVLDDDKVRQHWFVKFARNRGGLTDQDILRSEFHYYKALQKLGIETIAAEGLALE
EANKPSLWMQRFDRKVRDGDVSRLAVESIYSLAQVTTPGSAMNHMEVIRMLAGLWRQAGQASQIPALVTDYLRRDLINKI
LGNSDNHGRNTAIIRQANTFRLAPIYDLAPMVMDDEGVTRTTKWPRDLERAGDVDWRGVCRALADIAEPNDPLAALCDAP
ALFERLREDAQRLAALPDILTASGLPDRTMNHPGIHLKNLEQRLKEWDLQ

Download         Length: 1353 bp

>T214431 NZ_CP110072:c2488738-2488622 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10343.14 Da        Isoelectric Point: 10.7364

>AT214431 WP_128613606.1 NZ_CP082236:1772965-1773243 [Pseudomonas sp. SC3(2021)]
MTMTVAERTVLIESIQEALAQGTLEIGEAVRRLRVEVTGLHQTQFAKMCKISVRTLVHIEHGEGNQTLKSLNAVFRPFGL
KMGVVRVRREIN

Download         Length: 279 bp

>AT214431 NZ_CP110072:2488506-2488711 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References