Detailed information of TA system TA214428

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RHH
• Location: 175306..175819
• Replicon: chromosome
• Accession: NZ_CP082236
• Organism: Pseudomonas sp. SC3(2021)

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K5Y35_RS00845
• Protein ID: WP_128614018.1
• Coordinates: 175535..175819 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: K5Y35_RS00840
• Protein ID: WP_128614016.1
• Coordinates: 175306..175545 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K5Y35_RS00805	170566..170976	+	411	WP_123465408.1	low affinity iron permease family protein	-
K5Y35_RS00810	171067..171582	-	516	WP_128614009.1	DUF4142 domain-containing protein	-
K5Y35_RS00815	171655..171813	-	159	WP_003222499.1	KGG domain-containing protein	-
K5Y35_RS00820	171931..173280	-	1350	WP_222833497.1	GGDEF domain-containing protein	-
K5Y35_RS00825	173360..173998	-	639	WP_222833498.1	LysE family translocator	-
K5Y35_RS00830	174060..174476	-	417	WP_123465400.1	fosfomycin resistance glutathione transferase	-
K5Y35_RS00835	174481..175197	-	717	WP_128614015.1	hypothetical protein	-
K5Y35_RS00840	175306..175545	+	240	WP_128614016.1	ribbon-helix-helix protein, CopG family	Antitoxin
K5Y35_RS00845	175535..175819	+	285	WP_128614018.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K5Y35_RS00850	176211..177359	-	1149	WP_222833499.1	L-threonine dehydrogenase	-
K5Y35_RS00855	177514..178533	+	1020	WP_222833500.1	DUF4917 family protein	-
K5Y35_RS00860	178544..180403	-	1860	WP_222833501.1	right-handed parallel beta-helix repeat-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-41)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11051.82 Da
• Isoelectric Point: 10.8700

>T214428 WP_128614018.1 NZ_CP082236:175535-175819 [Pseudomonas sp. SC3(2021)]
MRIEWLKTALKNLDEEAAYIALENPKAASDFVQTILDNVDHLTRFPASGREGRLPGTREWIVPGRPYLIPYRVRQSRLQV
LRIFHTRRLPPKTW

Nucleotide

• Length: 285 bp

>T214428 NZ_CP110072:404139-404240 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8705.78 Da
• Isoelectric Point: 4.5535

>AT214428 WP_128614016.1 NZ_CP082236:175306-175545 [Pseudomonas sp. SC3(2021)]
MSIMSLRIPDEIADTLASLAKATGRSKSYLAVDALREYLAREAWQIEQIQQALKEADAGDFASADEVRAIAEKWNANAH

Nucleotide

• Length: 240 bp

>AT214428 NZ_CP110072:c404363-404185 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCG
AAAATCAGTAGTGCAACAA