Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4217527..4217891 Replicon chromosome
Accession NZ_CP082218
Organism Xanthomonas cucurbitae strain IL_234

Toxin (Protein)


Gene name EcnB Uniprot ID A0A0B2CMD0
Locus tag K6979_RS17990 Protein ID WP_016904515.1
Coordinates 4217527..4217661 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID H8FG64
Locus tag K6979_RS17995 Protein ID WP_003486606.1
Coordinates 4217739..4217891 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6979_RS17970 (K6979_17905) 4212879..4214531 - 1653 WP_170066936.1 M28 family metallopeptidase -
K6979_RS17975 (K6979_17910) 4214618..4215556 - 939 WP_104601866.1 MBL fold metallo-hydrolase -
K6979_RS17980 (K6979_17915) 4215640..4216929 - 1290 WP_170066931.1 tryptophan--tRNA ligase -
K6979_RS17985 (K6979_17920) 4217084..4217293 - 210 WP_104601868.1 CsbD family protein -
K6979_RS17990 (K6979_17925) 4217527..4217661 - 135 WP_016904515.1 entericidin A/B family lipoprotein Toxin
K6979_RS17995 (K6979_17930) 4217739..4217891 - 153 WP_003486606.1 entericidin A/B family lipoprotein Antitoxin
K6979_RS18000 (K6979_17935) 4218001..4218924 - 924 WP_104602004.1 arginase -
K6979_RS18005 (K6979_17940) 4219244..4219696 + 453 WP_104601869.1 roadblock/LC7 domain-containing protein -
K6979_RS18010 (K6979_17945) 4219764..4220123 + 360 WP_104601870.1 hypothetical protein -
K6979_RS18015 (K6979_17950) 4220218..4221135 + 918 WP_104601871.1 hypothetical protein -
K6979_RS18020 (K6979_17955) 4221132..4221671 + 540 WP_104601872.1 ATP/GTP-binding protein -
K6979_RS18025 (K6979_17960) 4222211..4222891 + 681 WP_104601873.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4443.26 Da        Isoelectric Point: 9.3487

>T214393 WP_016904515.1 NZ_CP082218:c4217661-4217527 [Xanthomonas cucurbitae]
MKRAIVLLVLSVLSVGMLSGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T214393 NZ_CP110063:2815662-2815811 [Enterococcus faecalis]
ATGCGTATGCACGTATTTCCGAAATTTAGAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGG
GTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5122.07 Da        Isoelectric Point: 8.7942

>AT214393 WP_003486606.1 NZ_CP082218:c4217891-4217739 [Xanthomonas cucurbitae]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT214393 NZ_CP110063:c2815928-2815744 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B2CMD0

Antitoxin

Source ID Structure
AlphaFold DB A0A828YLX6

References