Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 2223730..2224346 Replicon chromosome
Accession NZ_CP082218
Organism Xanthomonas cucurbitae strain IL_234

Toxin (Protein)


Gene name PumA Uniprot ID A0A853FWE4
Locus tag K6979_RS09280 Protein ID WP_048279626.1
Coordinates 2224050..2224346 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K6979_RS09275 Protein ID WP_048279629.1
Coordinates 2223730..2224044 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6979_RS09255 (K6979_09230) 2220182..2221390 + 1209 WP_016941853.1 site-specific integrase -
K6979_RS09260 (K6979_09235) 2221675..2221905 + 231 WP_104604568.1 AlpA family phage regulatory protein -
K6979_RS09265 (K6979_09240) 2221909..2222790 + 882 WP_104604570.1 helicase RepA family protein -
K6979_RS09270 (K6979_09245) 2222777..2223529 + 753 WP_104604572.1 ABC transporter ATPase -
K6979_RS09275 (K6979_09250) 2223730..2224044 - 315 WP_048279629.1 putative addiction module antidote protein Antitoxin
K6979_RS09280 (K6979_09255) 2224050..2224346 - 297 WP_048279626.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6979_RS09285 (K6979_09260) 2224792..2225118 - 327 WP_032422605.1 hypothetical protein -
K6979_RS09290 2225121..2225528 - 408 WP_249027663.1 hypothetical protein -
K6979_RS09295 (K6979_09270) 2225823..2227372 + 1550 Protein_1839 IS3 family transposase -
K6979_RS09300 (K6979_09275) 2227467..2228300 - 834 Protein_1840 P-type conjugative transfer protein TrbL -
K6979_RS09305 (K6979_09280) 2228405..2228587 - 183 WP_004690111.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2215249..2234662 19413


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-91)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11147.01 Da        Isoelectric Point: 10.4422

>T214391 WP_048279626.1 NZ_CP082218:c2224346-2224050 [Xanthomonas cucurbitae]
MIELIKTDLFDRWLVGLRDRQARARIEARIRRLSLGNPGDVKPVGEGLSEMRIDHGPGYRVYFMRRGPLVVLLLCGGDKS
SQERDIALAKTIAAQWKE

Download         Length: 297 bp

>T214391 NZ_CP110063:c2665500-2665399 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 10802.21 Da        Isoelectric Point: 4.7393

>AT214391 WP_048279629.1 NZ_CP082218:c2224044-2223730 [Xanthomonas cucurbitae]
MEVKFSRYDTADYLKTEDDIAAYLDAVMEDGDPALIAAALGDVARARNLSQLARDVGMSRQGLDKALSGDGNPSLATVVK
VAQALGLRLTFKPTHGGPAPAAGA

Download         Length: 315 bp

>AT214391 NZ_CP110063:2665275-2665454 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853FWE4

Antitoxin

Source ID Structure

References