214388

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4217422..4217786 Replicon chromosome
Accession NZ_CP082217
Organism Xanthomonas cucurbitae strain KS_456

Toxin (Protein)


Gene name EcnB Uniprot ID A0A0B2CMD0
Locus tag K6980_RS18010 Protein ID WP_016904515.1
Coordinates 4217422..4217556 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID H8FG64
Locus tag K6980_RS18015 Protein ID WP_003486606.1
Coordinates 4217634..4217786 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6980_RS17990 (K6980_17910) 4212774..4214426 - 1653 WP_170066936.1 M28 family metallopeptidase -
K6980_RS17995 (K6980_17915) 4214513..4215451 - 939 WP_104601866.1 MBL fold metallo-hydrolase -
K6980_RS18000 (K6980_17920) 4215535..4216824 - 1290 WP_170066931.1 tryptophan--tRNA ligase -
K6980_RS18005 (K6980_17925) 4216979..4217188 - 210 WP_104601868.1 CsbD family protein -
K6980_RS18010 (K6980_17930) 4217422..4217556 - 135 WP_016904515.1 entericidin A/B family lipoprotein Toxin
K6980_RS18015 (K6980_17935) 4217634..4217786 - 153 WP_003486606.1 entericidin A/B family lipoprotein Antitoxin
K6980_RS18020 (K6980_17940) 4217896..4218819 - 924 WP_104602004.1 arginase -
K6980_RS18025 (K6980_17945) 4219139..4219591 + 453 WP_104601869.1 roadblock/LC7 domain-containing protein -
K6980_RS18030 (K6980_17950) 4219659..4220018 + 360 WP_104601870.1 hypothetical protein -
K6980_RS18035 (K6980_17955) 4220113..4221030 + 918 WP_104601871.1 hypothetical protein -
K6980_RS18040 (K6980_17960) 4221027..4221566 + 540 WP_104601872.1 ATP/GTP-binding protein -
K6980_RS18045 (K6980_17965) 4222106..4222786 + 681 WP_104601873.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4443.26 Da        Isoelectric Point: 9.3487

>T214388 WP_016904515.1 NZ_CP082217:c4217556-4217422 [Xanthomonas cucurbitae]
MKRAIVLLVLSVLSVGMLSGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T214388 NZ_CP110063:433457-433765 [Enterococcus faecalis]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGACAACCAGGATCAGGGAAAACTAGTTTGCGATCGGCAATTT
CCGAAGAAACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCAAATTTTGACGAATTAGTG
AAACTCTATGAAAAAGACGTAGTAAAACATGCAACATCCTATTCTAATCAGCTGGTAAAGCTTAATTAG

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5122.07 Da        Isoelectric Point: 8.7942

>AT214388 WP_003486606.1 NZ_CP082217:c4217786-4217634 [Xanthomonas cucurbitae]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT214388 NZ_CP110063:433213-433455 [Enterococcus faecalis]
ATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGGGTATTAAATTATGTTTTGAATCATGAACTAGATACTAA
AAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCACAAGAAGTTGATTTATTTCAACAACCATTTG
AAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCAAAACAAATTTTGACAAAAGAGAAAGTGGCT
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B2CMD0

Antitoxin

Source ID Structure
AlphaFold DB A0A828YLX6

References