Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RHH
Location 10814..11367 Replicon plasmid unnamed
Accession NZ_CP082216
Organism Xanthomonas cucurbitae strain MI_359

Toxin (Protein)


Gene name relE Uniprot ID A0A1L5QZG5
Locus tag K6982_RS19760 Protein ID WP_054471487.1
Coordinates 10814..11107 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6M2VV98
Locus tag K6982_RS19765 Protein ID WP_005933935.1
Coordinates 11095..11367 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6982_RS19725 (K6982_19635) 6649..7419 + 771 WP_159408046.1 P-type conjugative transfer protein TrbJ -
K6982_RS19730 (K6982_19640) 7432..7665 + 234 WP_208800749.1 entry exclusion lipoprotein TrbK -
K6982_RS19735 (K6982_19645) 7677..9326 + 1650 WP_274392117.1 P-type conjugative transfer protein TrbL -
K6982_RS19740 (K6982_19650) 9329..9592 + 264 WP_159408054.1 hypothetical protein -
K6982_RS19745 (K6982_19655) 9653..9886 + 234 WP_159408053.1 type I toxin-antitoxin system ptaRNA1 family toxin -
K6982_RS19750 (K6982_19660) 10105..10452 - 348 WP_159408052.1 transcriptional regulator -
K6982_RS19755 (K6982_19665) 10449..10814 - 366 WP_159408051.1 XRE family transcriptional regulator -
K6982_RS19760 (K6982_19670) 10814..11107 - 294 WP_054471487.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6982_RS19765 (K6982_19675) 11095..11367 - 273 WP_005933935.1 CopG family ribbon-helix-helix protein Antitoxin
K6982_RS19770 (K6982_19680) 11564..12271 + 708 Protein_15 recombinase family protein -
K6982_RS19775 (K6982_19685) 12554..13186 + 633 WP_007966093.1 ParA family protein -
K6982_RS19780 (K6982_19690) 13179..13508 + 330 WP_011997475.1 hypothetical protein -
K6982_RS19785 (K6982_19695) 13592..13906 + 315 WP_159408049.1 ParC family partition-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..14122 14122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10811.34 Da        Isoelectric Point: 5.1583

>T214383 WP_054471487.1 NZ_CP082216:c11107-10814 [Xanthomonas cucurbitae]
VPQVIVTEGAAEGLERCRRFLAVKAPDAARRAGQAIERQFLLLETAPDIGRPFPEMPELRELVIAFGDSGYVALYRHEPA
DDAVYVLAFRHQKEAGY

Download         Length: 294 bp

>T214383 NZ_CP110059:2759411-2759551 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAGAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10545.84 Da        Isoelectric Point: 8.1081

>AT214383 WP_005933935.1 NZ_CP082216:c11367-11095 [Xanthomonas cucurbitae]
MATSLKIDDTLKGRVHHLASQRRRSPHWIMLEAIQQYVEREEARESFKQEALASWAAYKETGRHLTGQEVRTWLNTWGTS
DERAVPECHK

Download         Length: 273 bp

>AT214383 NZ_CP110059:c2759685-2759484 [Enterococcus faecalis]
GTTTTTTTAGGTGATTGTGCTGTAATAGCAATGAAAAGAGAGATATGCGCCAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGATCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L5QZG5

Antitoxin

Source ID Structure
AlphaFold DB A0A6M2VV98

References