214382

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4279689..4280053 Replicon chromosome
Accession NZ_CP082215
Organism Xanthomonas cucurbitae strain MI_359

Toxin (Protein)


Gene name EcnB Uniprot ID A0A0B2CMD0
Locus tag K6982_RS18355 Protein ID WP_016904515.1
Coordinates 4279689..4279823 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID H8FG64
Locus tag K6982_RS18360 Protein ID WP_003486606.1
Coordinates 4279901..4280053 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6982_RS18335 (K6982_18245) 4275040..4276692 - 1653 WP_167526970.1 M28 family metallopeptidase -
K6982_RS18340 (K6982_18250) 4276780..4277718 - 939 WP_159407775.1 MBL fold metallo-hydrolase -
K6982_RS18345 (K6982_18255) 4277802..4279091 - 1290 WP_167526971.1 tryptophan--tRNA ligase -
K6982_RS18350 (K6982_18260) 4279246..4279455 - 210 WP_104601868.1 CsbD family protein -
K6982_RS18355 (K6982_18265) 4279689..4279823 - 135 WP_016904515.1 entericidin A/B family lipoprotein Toxin
K6982_RS18360 (K6982_18270) 4279901..4280053 - 153 WP_003486606.1 entericidin A/B family lipoprotein Antitoxin
K6982_RS18365 (K6982_18275) 4280163..4281086 - 924 WP_104602004.1 arginase -
K6982_RS18370 (K6982_18280) 4281406..4281858 + 453 WP_159407777.1 roadblock/LC7 domain-containing protein -
K6982_RS18375 (K6982_18285) 4281926..4282285 + 360 WP_104601870.1 hypothetical protein -
K6982_RS18380 (K6982_18290) 4282380..4283297 + 918 WP_159407778.1 hypothetical protein -
K6982_RS18385 (K6982_18295) 4283294..4283833 + 540 WP_104601872.1 ATP/GTP-binding protein -
K6982_RS18390 (K6982_18300) 4284373..4285053 + 681 WP_104601873.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4443.26 Da        Isoelectric Point: 9.3487

>T214382 WP_016904515.1 NZ_CP082215:c4279823-4279689 [Xanthomonas cucurbitae]
MKRAIVLLVLSVLSVGMLSGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T214382 NZ_CP110059:2759411-2759551 [Enterococcus faecalis]
ATTTCTCTGAAAAATACGAATAGAAATATCGTTTACTGTACAACATATGAAACAATTCAGACGATCCTAGGGTTTGGTAT
GTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5122.07 Da        Isoelectric Point: 8.7942

>AT214382 WP_003486606.1 NZ_CP082215:c4280053-4279901 [Xanthomonas cucurbitae]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT214382 NZ_CP110059:c2759409-2759266 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B2CMD0

Antitoxin

Source ID Structure
AlphaFold DB A0A828YLX6

References